Neil Kaplowitz – 1 November 1992

Richard Sallie, Leah Katsiyiannakis, Dianne Baldwin, Sue Davies, John O'Grady, Alex Mowat, Giorgina Mieli‐Vergani, Roger Williams – 1 November 1992 – Serum, urine and tissue biochemical findings were studied in 21 cases of fulminant Wilson's disease with respect to the value of a recently described biochemical index based on serum alkaline phosphatase and total serum bilirubin levels, and these cases were compared with 193 other cases of fulminant liver failure.

Stuart I. Myers, Lori Bartula – 1 November 1992 – Microsomal prostanoid synthesis was compared in normal gallbladders removed during organ donation and inflamed gallbladders removed at cholecystectomy. Normal human gallbladder microsomes demonstrated low rates of conversion of [14C]arachidonic acid to total labeled prostanoids, which increased during 1 to 30 min of incubation. Normal human gallbladder microsomes converted labeled substrate to all primary prostaglandins without demonstration of a major product.

Lynne W. Elmore, Alphonse E. Sirica – 1 November 1992 – Furan rapidly induces in rat liver a unique, lobespecific pattern of development of intestinal metaplasia and associated cholangiofibrosis. To establish early cell‐precursor relationships in the genesis of this cholangiofibrosis, a time‐course study was conducted in which young adult male Fisher 344 rats received furan by gavage at a daily dose of 45 mg/kg body wt over a 32‐day treatment period.

Anna Mae Diehl, Shi Qi Yang, Piera Cote, Gary S. Wand – 1 November 1992 – Evidence suggests that ethanol desensitizes hepatocytes to the trophic effects of hormones. Cyclic AMP–dependent signals are important regulators of intermediary metabolism, cellular proliferation and differentiation, and modulate liver growth during hepatic regeneration.

Jens H. Henriksen, Flemming Bendtsen, Alexander L. Gerbes, Niels Juel Christensen, Helmer Ring‐Larsen, Thorkild I. A. Sørensen – 1 November 1992 – The estimated central blood volume (i.e., blood volume in the heart cavities, lungs and central arterial tree) was determined by multiplying cardiac output by circulatory mean transit time in 19 patients with cirrhosis and compared with sympathetic nervous activity and circulating level of atrial natriuretic factor. Arterial norepinephrine level, an index of overall sympathetic nervous activity (3.08 nmol/L in patients vs.

Denis Devictor, Laurence Desplanques, Dominique Debray, Yves Ozier, Anne‐Marie Dubousset, Jacques Valayer, Didier Houssin, Olivier Bernard, Gilbert Huault – 1 November 1992 – We report our results with orthotopic liver transplantation in children with fulminant liver failure. Thirty‐five children with fulminant liver failure were evaluated for liver transplantation. The main causes of liver failure were viral hepatitis (54.2%), drug‐induced liver injury (14.2%) and Wilson's disease (11.4%).

Oliver Esch, John C. Spinosa, Ronald L. Hamilton, Diane L. Crombie, Claudio D. Schteingart, Joseph F. Rondinone, Horacio B. D'Agostino, Jan Lillienau, Alan F. Hofmann – 1 October 1992 – Experiments were performed in anesthetized rabbits and piglets to assess gallbladder mucosal injury during irrigation with methyl tert‐butyl ether, a C5 ether, or ethyl propionate, a C5 ester—two organic solvents used in the contact dissolution of cholesterol gallstones.

Neil D. Theise, Myron Schwartz, Charles Miller, Swan N. Thung – 1 October 1992 – Macroregenerative nodules, also called nodules of adenomatous hyperplasia, have been well documented in Japan. Extensive studies support the hypothesis that in the Japanese population these lesions represent a possible pathway for hepatocarcinogenesis. However, reporting of these lesions in non‐Japanese populations has so far been rare. We examined 44 sequential cirrhotic hepatectomy specimens from adult patients who underwent orthotopic liver transplantation at our institution.

Olivier Ink, Thierry Martin, Thierry Poynard, Marc Reville, Marie‐Laure Anciaux, Claude Lenoir, Jean‐Luc Marill, Hélène Labadie, Claude Masliah, Daniel Perrin, Jean‐Claude Chaput, Denis Vetter, Claude Eugene, Louis Lebodic, Henri Licht, Jean‐Pierre Etienne – 1 October 1992 – We conducted a prospective, multicenter, randomized trial to compare the efficacy of sclerotherapy plus propranolol with that of propranolol alone in the prevention of recurrent gastroesophageal bleeding in severely cirrhotic patients.