Daphna Fenyves, Louise Gariépy, Jean‐Pierre Villeneuve – 1 February 1993 – To delineate the factors responsible for impaired clearance in cirrhosis, we examined propranolol disposition in rats with carbon tetrachloride–induced cirrhosis and compared it with that in control animals, rats treated with chlorpromazine (an inhibitor of propranolol metabolism) and rats with acute liver injury. We measured the extraction ratio of propranolol by the isolated perfused liver and related it to estimates of propranolol drug‐metabolizing enzyme activity in homogenates of the same livers.

Antoine Hadengue, Didier Lebrec, Richard Moreau, Philippe Sogni, François Durand, Christophe Gaudin, Jacques Bernuau, Jacques Belghiti, Brice Gayet, Serge Erlinger, Jean‐Pierre Benhamou – 1 February 1993 – Portal pressure and portal‐systemic collateral circulation after orthotopic liver transplantation have not been investigated. We studied systemic and splanchnic hemodynamics in 17 patients with cirrhosis before and 205 ± 146 days after orthotopic liver transplantation.

Glynn Bolitho, Gert Engelbrecht, Zoe Lotz, Marilyn Tyler, Heather McLeod, Kaz Jaskiewicz, Rosemary Hickman – 1 February 1993 – Current knowledge of liver regeneration after reduced liver transplantation is limited. Warm ischemia is one component of the reduced liver transplantation procedure that could have an impact on the regenerative response.

Alain Dubois, Michel Dauzat, Christine Pignodel, Gilles Pomier‐Layrargues, Christiane Marty‐Double, François‐Michel Lopez, Charles Janbon – 1 February 1993 – The pathogenesis of portal hypertension in patients with lymphoproliferative and myeloproliferative disorders is not fully understood. We investigated 20 patients with myeloproliferative disease and 47 patients with lymphoproliferative disease.

Liliana Chemello, Daniela Cavalletto, Patrizia Pontisso, Flavia Bortolotti, Carlo Donada, Valter Donadon, Mario Frezza, Pietro Casarin, Alfredo Alberti – 1 February 1993 – Patients with hepatitis C virus infection may have circulating antibodies to various structural and nonstructural antigens of the virus.

Etienne Marc Sokal, Elizabeth Collette, Jean Paul Buts – 1 February 1993 – To determine the zonal distribution of alcohol dehydrogenase in normal and cirrhotic human livers, we measured activities of this enzyme by quantitative cytochemical analysis along the liver cell plate in liver specimens from 10 normal organ donors and from 7 children with extrahepatic biliary atresia cirrhosis.

Jany Vassy, Jean Paul Rigaut, Dominique Briane, Michel Kraemer – 1 February 1993 – Immunolocalization of desmin in fetal rat livers shows that on day 12 of gestation a high number of liver cells express desmin. This number decreases from day 14 onward. On day 20 about the same density of desmin‐containing cells is found in fetal rat livers as is found in adult rat livers.

Ethel L. Macintosh, Tony Gauthier, Norman M. Pettigrew, Gerald Y. Minuk – 1 February 1993 – Liver regeneration is an essential component of the recovery period after partial hepatectomy. Unfortunately, tests that accurately predict regenerative activity in the postoperative period have yet to be described. This study was designed to determine whether the extent of hepatic fibrosis correlates with liver regeneration activity after partial hepatectomy in rats with carbon tetrachloride–induced liver disease.

Jorge J. Gumucio, Dale Bachwich, Jules Dienstag – 1 February 1993 – Objective. – To test the hypothesis that the rare, often fatal, syndrome of hepatitis‐associated aplasia is associated with hepatitis C virus infection.

Kenneth S. Lown – 1 February 1993 – Mutations at amino acid positions 67, 70, 215, and 219 in the human immunodeficiency virus type 1 (HIV‐1) pol gene correlate with the emergence of resistance to zidovudine (AZT). These four positions were monitored in viral RNA extracted from infected peripheral blood mononuclear cells (PBMC) and viral stocks obtained after coculture with uninfected lymphocytes. Genotype determinations were made using the selfsustained sequence replication (3SR) and differential bead‐based sandwich hybridization (BBSH) assay.