Antonio Francavilla, Alessandro Azzarone, Guiseppe Carrieri, Carlo Scotti‐Fogueni, Qia‐Hua Zeng, Umberto Cillo, Kendrick Porter, Thomas E. Starzl – 1 November 1992 – Transforming growth factor‐β canceled the hepatocyte proliferation caused by transforming growth factor‐α when the two substances were mixed and administered through a disconnected central portal vein branch after creation of an Eck fistula.

Pierre Laurent‐Puig, Jean‐François Flejou, Monique Fabre, Pierre Bedossa, Jacques Belghiti, François Gayral, Dominique Franco – 1 November 1992 – Mutant p53 has been found in a wide variety of human malignancies including carcinomas of the lung, breast and colon.

Philippe Sogni, Richard Moreau, Masaru Ohsuga, Stephane Cailmail, Frederic Oberti, Antoine Hadengue, Eric Pussard, Didier Lebrec – 1 October 1992 – Because it has been hypothesized that the hyperkinetic circulation in portal hypertension is the result of increased synthesis of nitric oxide, we compared the hemodynamic effects of nitric oxide synthesis—specific agonist (L‐arginine) and antagonist between normal and cirrhotic conscious rats. The dose‐response curves showed that L‐arginine significantly decreased arterial pressure and increased heart rate.

Tomihiro Hayakawa, Kenji Katagiri, Makoto Hoshino, Tomio Nakai, Takayuki Ohiwa, Tomoyuki Kumai, Makoto Miyaji, Toshihiko Takeuchi, James Corasanti, James L. Boyer – 1 October 1992 – Papaverine is a nonspecific smooth muscle relaxant and a phosphodiesterase inhibitor. Its effects on biliary excretion of lipids and horseradish peroxidase were investigated in a single‐pass isolated perfused rat liver model. A constant infusion of papaverine (1.6 μmol/min; 40 μmol/L) significantly increased bile flow (microliters per minute per gram of liver) before (2.03 ± 0.09 vs.

1 October 1992

Steven R. Martin – 1 October 1992

Jonathan B. Kruskal, Simon C. Robson, John J. Franks, Ralph E. Kirsch – 1 October 1992 – Patients with liver disease have a variety of coagulation abnormalities. These derangements are of uncertain origin and do not always correlate with disease severity or activity.

Tirso Castillo, Dennis R. Koop, Seiichiro Kamimura, George Triadafilopoulos, Hidekazu Tsukamoto – 1 October 1992 – This study investigated the role of cytochrome P‐450 2E1 in enhanced microsomal lipid peroxidation in experimental alcoholic liver disease. We also examined the contribution of this isoform to the increased microsomal injury in alcoholic liver disease caused by carbon tetrachloride—induced or iron‐induced oxidant stress.

Fa‐Yauh Lee, Agustin Albillos, Luis A. Colombato, Roberto J. Groszmann – 1 October 1992 – This study examined whether an increased activity of the endothelium‐derived relaxing factor, nitric oxide, may account for the hyporesponsiveness to vasoconstrictors in portal hypertension. We performed dose‐response curves to methoxamine, an α‐adrenoceptor agonist, with and without Nω‐nitro‐L‐arginine, a specific inhibitor of nitric oxide synthesis, in experimental portal hypertension.

Ravikumar P. Vemuru, Emma Aragona, Sanjeev Gupta – 1 October 1992 – Assessment of liver regeneration with endogenous genes that are expressed during DNA replication is physiological, specific and direct. To determine whether H3 histone messenger RNA expression (which is tightly coupled with DNA synthesis) could be used for this purpose, we initially examined liver regeneration in a mouse model. After partial hepatectomy, RNA transblot studies showed induction of H3 histone messenger RNA expression in regenerating mouse livers.