Complications of chronic liver disease. Edited by William G. Rector, Jr., 383 pp. St. Louis: Mosby–Year Book, 1992. $65
Henry C. Bodenheimer – 1 November 1992
Direct evidence that hepatocyte growth factor is a hepatotrophic factor for liver regeneration and has a potent antihepatitis effect in vivo
Yoshihide Ishiki, Hiroo Ohnishi, Yasutoshi Muto, Kunio Matsumoto, Toshikazu Nakamura – 1 November 1992 – Hepatocyte growth factor, a potent mitogen for mature hepatocytes in vitro, seems to function as a hepatotrophic factor for liver regeneration. We examined the mitogenic effect of hepatocyte growth factor on mouse liver in vivo.
Effect on the canine Eck fistula liver of intraportal TGF‐β alone or with hepatic growth factors
Antonio Francavilla, Alessandro Azzarone, Guiseppe Carrieri, Carlo Scotti‐Fogueni, Qia‐Hua Zeng, Umberto Cillo, Kendrick Porter, Thomas E. Starzl – 1 November 1992 – Transforming growth factor‐β canceled the hepatocyte proliferation caused by transforming growth factor‐α when the two substances were mixed and administered through a disconnected central portal vein branch after creation of an Eck fistula.
Overexpression of p53: A rare event in a large series of white patients with hepatocellular carcinoma
Pierre Laurent‐Puig, Jean‐François Flejou, Monique Fabre, Pierre Bedossa, Jacques Belghiti, François Gayral, Dominique Franco – 1 November 1992 – Mutant p53 has been found in a wide variety of human malignancies including carcinomas of the lung, breast and colon.
Evidence for normal nitric oxide—mediated vasodilator tone in conscious rats with cirrhosis
Philippe Sogni, Richard Moreau, Masaru Ohsuga, Stephane Cailmail, Frederic Oberti, Antoine Hadengue, Eric Pussard, Didier Lebrec – 1 October 1992 – Because it has been hypothesized that the hyperkinetic circulation in portal hypertension is the result of increased synthesis of nitric oxide, we compared the hemodynamic effects of nitric oxide synthesis—specific agonist (L‐arginine) and antagonist between normal and cirrhotic conscious rats. The dose‐response curves showed that L‐arginine significantly decreased arterial pressure and increased heart rate.
Papaverine inhibits transcytotic vesicle transport and lipid excretion into bile in isolated perfused rat liver
Tomihiro Hayakawa, Kenji Katagiri, Makoto Hoshino, Tomio Nakai, Takayuki Ohiwa, Tomoyuki Kumai, Makoto Miyaji, Toshihiko Takeuchi, James Corasanti, James L. Boyer – 1 October 1992 – Papaverine is a nonspecific smooth muscle relaxant and a phosphodiesterase inhibitor. Its effects on biliary excretion of lipids and horseradish peroxidase were investigated in a single‐pass isolated perfused rat liver model. A constant infusion of papaverine (1.6 μmol/min; 40 μmol/L) significantly increased bile flow (microliters per minute per gram of liver) before (2.03 ± 0.09 vs.
Reviews elsewhere
1 October 1992
Elevated fibrin‐related and fibrinogen‐related antigens in patients with liver disease
Jonathan B. Kruskal, Simon C. Robson, John J. Franks, Ralph E. Kirsch – 1 October 1992 – Patients with liver disease have a variety of coagulation abnormalities. These derangements are of uncertain origin and do not always correlate with disease severity or activity.
Role of cytochrome P‐450 2E1 in ethanol‐, carbon tetrachloride— and iron‐dependent microsomal lipid peroxidation
Tirso Castillo, Dennis R. Koop, Seiichiro Kamimura, George Triadafilopoulos, Hidekazu Tsukamoto – 1 October 1992 – This study investigated the role of cytochrome P‐450 2E1 in enhanced microsomal lipid peroxidation in experimental alcoholic liver disease. We also examined the contribution of this isoform to the increased microsomal injury in alcoholic liver disease caused by carbon tetrachloride—induced or iron‐induced oxidant stress.