Lymphocyte Adherence in the Reperfused Rat Liver: Mechanisms and Effects

Pierre‐Alain Clavien, P. Robert C. Harvey, Juan R. Sanabria, Robert Cywes, Gary A. Levy, Steven M. Strasberg – 1 January 1993 – Leukocyte adhesion may play a central role in the pathogenesis of preservation‐reperfusion injury to liver grafts. We previously showed that lymphocyte adhesion to sinusoids is dependent on the length of cold ischemia. In the present study we examined the mechanisms of lymphocyte adherence after harvesting combined with a short and a long preservation time. The effects of lymphocyte adherence on liver function were also examined.

Prevalence of Hepatitis C Virus Infection in Hemodialysis Patients: A Longitudinal Study Comparing the Results of RNA and Antibody Assays

Tak Mao Chan, Anna Suk Fong Lok, Ignatius Kum Po Cheng, Rachel Tzun Chan – 1 January 1993 – We longitudinally studied 51 patients from two hemodialysis centers to determine the prevalence of hepatitis C virus infection in hemodialysis patients. Serum samples were tested for antibody to HCV by first‐ and second‐ generation enzyme immunoassays and for hepatitis C virus RNA by nested polymerase chain reaction assay.

Persistence of Hepatitis B and Hepatitis C Viral Genomes in Primary Liver Cancers from HBsAg‐Negative Patients: A Study of a Low‐endemic Area

Patrizia Paterlini, Françoise Driss, Bertrand Nalpas, Emilio Pisi, Dominique Franco, Pierre Berthelot, Christian Bréchot – 1 January 1993 – The role of HBV and HCV in the course of primary liver cancer in patients who are negative for HBsAg has been debated. Using a combination of serological and polymerase chain reaction assays, we investigated the association between HCV and HBV infections and primary liver cancer in 24 HBsAg‐negative patients living in France. The presence of HCV RNA and HBV DNA sequences was tested for in serum and in tumorous and nontumorous liver samples.

Differentiation Between Heterozygotes and Homozygotes in Genetic Hemochromatosis by Means of a Histological Hepatic Iron Index: A Study of 192 Cases

Yves M. Deugnier, Bruno Turlin, Romain Moirand, Olivier Loréal, Pierre Brissot, Lawrie W. Powell, Kim M. Summers, Linda Fletcher, June W. Halliday – 1 January 1993 – The biochemical hepatic iron index, defined as the ratio of hepatic iron concentration (expressed as micromoles per gram dry weight) to age permits accurate prediction of genetic status in patients with genetic hemochromatosis. However, the hepatic iron concentration is not always available.

Depression of Drug‐metabolizing Activity in the Human Liver by Interferon‐β

Hiroyasu Okuno, Masashi Takasu, Haruhiko Kano, Toshihito Seki, Yasuko Shiozaki, Kyoichi Inoue – 1 January 1993 – The depressant effect of interferon beta on drugmetabolizing activity in the human liver was investigated. Seven patients with chronic hepatitis C were treated with interferon beta at doses of 3 × 106 to 9 × 106 IU/day for 8 wk. The activities of 7‐methoxycoumarin O‐demethylase and 7‐ethoxycoumarin O‐deethylase in specimens obtained by liver biopsy were examined before and after interferon treatment.

Hyperfibrinolysis Resulting from Clotting Activation in Patients with Different Degrees of Cirrhosis

Francesco Violi, Domenico Ferro, Claudio Quintarelli, Antonio Musca, Francesco Balsano, Corrado Cordova, Stefania Basili, The Calc Group – 1 January 1993 – This study explored the relationship between clotting activation and tissue plasminogen activator and its inhibitor in cirrhotic patients with different degrees of liver failure. Sixty‐seven patients (40 men, 27 women; age = 31–77 yr) with cirrhosis diagnosed by liver biopsy were divided into three subgroups (A, B and C) on the basis of Child‐Pugh classification.

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