Jorge J. Gumucio, Rolf Gebhardt – 1 September 1992 – We previously demonstrated that glutamine synthetase (GS) and ornithine aminotransferase (OAT) mRNAs are expressed in the mouse liver acinus preferentially in pericentral hepatocytes, that is, those immediately surrounding terminal central veins (A. L. Bennett, K. E. Paulson, R. E. Miller, and J. E. Darnell, Jr., J. Cell Biol. 105:1073–1085, 1987, and F. C. Kuo, W. L. Hwu, D. Valle, and J. E. Darnell, Jr., Proc. Natl. Acad. Sci. USA, (in press).

Irmin Sternlieb – 1 September 1992 – Three distinct patterns of structural abnormalities of mitochondria, indicated as types I, II and III and associated with steatosis, were identified in the hepatocytes of 40 of 42 asymptomatic and 8 of 22 symptomatic patients with documented Wilson's disease before treatment. No correlation was seen between the type of mitochondrial abnormality and the patient's age, hepatic copper concentration, degree of hepatic steatosis or serum aminotransferase level.

Tilo Andus, Volker Gross, Axel Holstege, Margit Ott, Marlies Weber, Martina David, Harald Gallati, Wolfgang Gerok, Jürgen Schölmerich – 1 September 1992 – Ascites and plasma concentrations of soluble tumor necrosis factor receptors p55 and p75 were measured in a prospective study in 34 patients (35 occasions of ascites) with hepatic (5 infected and 21 uninfected) and malignancy‐related (9) ascites.

1 September 1992

Fuyo Yoshimi, Takeshi Nagao, Sumio Inoue, Nobuhiro Kawano, Tetsuichiro Muto, Toshiaki Gunji, Shin Ohnishi, Michio Imawari – 1 September 1992 – Transcatheter arterial chemoembolization is now widely used in cases of surgically unresectable hepatocellular carcinoma. However, it is unclear whether patients with surgically resectable hepatocellular carcinoma should always be treated with hepatectomy as opposed to transcatheter arterial chemoembolization.

Tohru Utsunomiya, Takashi Matsumata, Eisuke Adachi, Hiroshi Honda, Keizo Sugimachi – 1 September 1992 – To determine the limitations of the latest techniques in preoperative liver imaging for hepatocellular carcinoma, 20 patients with histologically proven intrahepatic metastatic tumors were studied. In 32 masses, we were able to assess the relationship between these intrahepatic metastatic tumors and the findings of preoperative imaging individually. Six intrahepatic metastatic tumors not exceeding 5 mm in diameter were missed in all the imaging examinations.

Stefan Post, Alberto P. Gonzalez, Pablo Palma, Markus Rentsch, Adolf Stiehl, Michael D. Menger – 1 September 1992 – Phagocytic activity of sinusoidal lining cells was studied in 32 livers of male Lewis rats by in vivo fluorescence microscopy with epiillumination. Normal livers (group 1, n = 8) were compared with orthotopic syngeneic liver grafts 90 min after reperfusion after a period of cold storage in University of Wisconsin solution for 17 hr (group 2, n = 10) or 24 hr (group 3. n = 14).

Seon‐Kyeong Kim, Folkert O. Belzer, James H. Southard – 1 September 1992 – Preservation of the liver involves a period of cold (0° to 4°C) ischemia; the longer the ischemic period, the greater the injury to the liver. The mechanisms for cold‐induced ischemic injury are not known, but it is clear that after preservation the liver has a reduced capacity to regenerate high‐energy phosphate compounds (ATP). One cause for the delayed rate of ATP synthesis could be injury to the mitochondria.

Keith S. Henley, Michael R. Lucey, Henry D. Appelman, Prabhakar Baliga, Kimberly A. Brown, Gordon D. Burtch, Darrell A. Campbell, John M. Ham, Robert M. Merion, Jeremiah G. Turcotte – 1 September 1992 – It is not known whether the histopathology of the liver allograft can be predicted from biochemical measurements in serum with the same confidence as in the native liver.

Stefan Schwögler, Margarete Odenthal, Thomas Knittel, Karl‐Hermann Meyer zum Büschenfelde, Giuliano Ramadori – 1 September 1992 – During liver fibrogenesis, fat‐storing cells transform into myofibroblast‐like cells and produce increasing amounts of extracellular matrix proteins. Because fat‐storing cells produce α2‐macroglobulin, an important serine protease inhibitor (serpin), we investigated whether fat‐storing cells also synthesize C1‐esterase inhibitor, another important serpin.