Neil D. Theise, Myron Schwartz, Charles Miller, Swan N. Thung – 1 October 1992 – Macroregenerative nodules, also called nodules of adenomatous hyperplasia, have been well documented in Japan. Extensive studies support the hypothesis that in the Japanese population these lesions represent a possible pathway for hepatocarcinogenesis. However, reporting of these lesions in non‐Japanese populations has so far been rare. We examined 44 sequential cirrhotic hepatectomy specimens from adult patients who underwent orthotopic liver transplantation at our institution.

Oliver Esch, John C. Spinosa, Ronald L. Hamilton, Diane L. Crombie, Claudio D. Schteingart, Joseph F. Rondinone, Horacio B. D'Agostino, Jan Lillienau, Alan F. Hofmann – 1 October 1992 – Experiments were performed in anesthetized rabbits and piglets to assess gallbladder mucosal injury during irrigation with methyl tert‐butyl ether, a C5 ether, or ethyl propionate, a C5 ester—two organic solvents used in the contact dissolution of cholesterol gallstones.

Shun‐Ichi Okada, Yoshihirc Akahane, Hiroshi Suzuki, Hiroaki Okamoto, Shunji Mishiro – 1 September 1992 – We investigated amino acid heterogeneity in the variable regions of the E2/NS1 viral protein in interferon‐responsive and interferon‐nonresponsive patients with chronic hepatitis C virus infection. The study assessed whether any particular heterogeneity pattern(s) could be useful in predicting responsiveness to interferon treatment.

Anthony J. Demetris, Kenjiro Nakamura, Atsuhito Yagihashi, Yuichi Iwaki, Shunichi Takaya, Grace G. Hartman, Noriko Murase, Oscar Bronsther, Rafael Manez, John J. Fung, Shunzaburo Iwatsuki, Thomas E. Starzl – 1 September 1992 – Twenty‐six adult patients with preformed IgG donor lymphocytotoxic antibodies received primary liver allografts under FK 506 immunosuppression. The effect of the crossmatch‐positive state on early graft function and on the immunopathological and histopathological findings was compared with that of 52 crossmatch‐negative control recipients.

América Giménez, Joan Caballería, Albert Parés, Silvia Alié, Ramón Deulofeu, Hernán Andreu, Joan Rodés – 1 September 1992 – The effects of dietary zinc on hepatic collagen and prolyl hydroxylase activity in normal and alcoholic rats has been investigated in four groups of pair‐fed male Wistar rats given either liquid ethanol or a control diet for 12 wk. Each group of pair‐fed animals received a diet with a different zinc concentration (standard diet, 7.6 mg/L; low‐zinc diet, 3.4 mg/L; zinc‐supplemented diet, 76 mg/L; and zincextrasupplemented, 300 mg/L.

Zvi Ackerman, Boontar Valinluck, John G. McHutchison, Allan G. Redeker, Sugantha Govindarajan – 1 September 1992 – Forty‐six patients with chronic hepatitis delta virus infection were followed between 6 and 116 mo (mean = 32.8 mo; median = 24 mo). Nineteen patients (41%) demonstrated clinical courses with episodes of biochemical reactivation (ALT levels ≥ 10 times baseline values [group A]). Twenty‐seven patients (59%) had stable clinical courses without biochemical reactivation (group B). Patients in group A were younger than those in group B (30.5 vs.

Josep Llach, Antoni Rimola, Miquel Navasa, Pere Ginès, Joan M. Salmerón, Angels Ginès, Vicente Arroyo, Joan Rodés – 1 September 1992 – To investigate the long‐term probability of the appearance of the first episode of spontaneous bacterial peritonitis in cirrhosis with ascites and to identify predictors of this complication, we closely followed throughout their illness 127 patients consecutively admitted to our unit for the treatment of an episode of ascites without prior spontaneous bacterial peritonitis (follow‐up period: 21 ± 22 mo).

José Antonio Girón, Melchor Alvarez‐Mon, José Luis Menéndez‐Caro, Luis Abreu, Agustín Albillos, Luis Manzano, Alberto Durántez – 1 September 1992 – Immunoglobulin secretion by B lymphocytes is a complex process in which lymphokines secreted by T lymphocytes play an important regulatory role. Increased serum levels of IgA and IgG have been characteristically detected in patients with alcoholic cirrhosis. We have studied the functional alterations of T and B lymphocytes implicated in the physiopathology of this common immunoglobulin abnormality.

Colin N. A. Palmer, Philip J. Coates, Susan E. Davies, Elizabeth A. Shephard, Ian R. Phillips – 1 September 1992 – The localization of the expression of several cytochrome P‐450 genes in normal and diseased human liver was investigated by in situ hybridization of formalin‐fixed, paraffin wax–embedded archival tissue samples with 35S‐labeled antisense RNA probes.

Alexander L. Gerbes, Rochus Witthaut, Veit Gülberg, Gaétan Thibault, Manfred Bilzer, Dieter Jüngst – 1 September 1992 – Mesenteric, hepatic and splanchnic extraction of C‐terminal and N‐terminal atrial natriuretic factor was investigated in male Sprague‐Dawley rats. Plasma concentrations (mean ± S.E.M.) of C‐terminal atrial natriuretic factor were 55.0 ± 6.1 fmol/ml, 31.2 ± 4.0 fmol/ml and 23.5 ± 3.3 fmol/ml (n = 12) in the abdominal aorta, the portal vein and the hepatic vein, respectively.