Raymond S. Koff – 1 September 1993

Julio Vorobioff, Eduardo Picabea, Marcelo Gamen, Roberto Villavicencio, Juan Bordato, Fernando Bessone, Hugo Tanno, Jorge Palazzi, Hector Sarano, Luisa Pozzoli, Roberto Sanchez, Ricardo Giordano – 1 September 1993 – The long‐term hemodynamic and renal effects of propranolol were compared with those of propranolol plus isosorbide dinitrate in 44 portal‐hypertensive alcoholic cirrhotic patients. Eight control patients, 8 patients receiving propranolol and 14 patients receiving propranolol plus isosorbide dinitrate were hemodynamically evaluated.

Germana V. Gregorio, Giorgina Mieli‐Vergani – 1 September 1993

Robert Cywes, Marian A. Packham, Linda Tietze, Juan R. Sanabria, P. Robert C. Harvey, M. James Phillips, Steven M. Strasberg – 1 September 1993 – Cold preservation of liver allografts injures hepatic sinusoidal lining cells. This injury is exacerbated on reperfusion, in part because of adhesion of leukocytes. Platelets also adhere to activated endothelial surfaces. In this study we examined the role of platelets in preservation injury.

María Casadevall, Julián Panés, Josep M. Piqué, Norma Marroni, Jaume Bosch, Brendan J. R. Whittle – 1 September 1993 – This study investigates the effects of inhibition of nitric oxide synthesis by NG‐nitro‐L‐arginine methyl ester (L‐NAME), the inhibition of prostaglandin synthesis with indomethacin and the combined effects on gastric mucosal hyperemia of ketamine‐anesthetized rats with portal hypertension induced by partial portal vein ligation. The hydrogen gas–clearance technique was used for measurement of gastric mucosal blood flow.

Yasuni Nakanuma – 1 September 1993 – Primary biliary cirrhosis is characterized by the immune‐mediated, nonsuppurative destruction of intrahepatic small bile ducts, with significant T‐cell involvement. To date, B cells in livers of primary biliary cirrhosis patients have been ignored in immunopathological evaluations of nonsuppurative cholangitis. This study aimed to correlate the distribution of activated T and B cells with the histopathology of nonsuppurative cholangitis in primary biliary cirrhosis, with emphasis on B cell infiltration.

Peter H. McGuinness, G. Alex Bishop, Alfred Lien, Brenton Wiley, Carolyn Parsons, Geoffrey W. McCaughan – 1 September 1993 – Approximately 90% of subjects with chronic hepatitis resulting from hepatitis C virus infection have hepatitis C virus RNA in serum. However, the prevalence of hepatitis C virus RNA in serum from subjects with hepatitis C virus antibody associated with persistent normal liver biochemical values is unclear. Do these subjects have resolved or continuing infection with hepatitis C virus?

Raimund Kaserbacher, Theresa Propst, Albert Propst, Ivo Graziadei, Gert Judmaier, Wolfgang Vogel – 1 September 1993

Martin Volkmann, Martina Müller, Walter J. Hofmann, Martina Meyer, Jens Hagelstein, Ulrich Räth, Burkhard Kommerell, Hanswalter Zentgraf, Peter R. Galle – 1 September 1993 – Recently, p53 gene aberrations have been recognized as a relevant factor in hepatocarcinogenesis, in tumors from both high‐risk and low‐risk areas. Because p53 gene mutations typically result in increased p53 levels in tumor cells, this cellular protein might become immunogenic during tumor development.

Marcus K. H. Auth, Raymond A. Keitzer, Martin Scholz, Roman A. Blaheta, E. Christoph Hottenrott, Günther Herrmann, Albrecht Encke, Bernd H. Markus – 1 September 1993 – Biliary epithelial cells are a primary site of damage in liver allograft rejection and in immunologically mediated diseases such as primary biliary cirrhosis. Human leukocyte antigens and adhesion molecules on the biliary epithelium are associated with T‐lymphocytic binding, recognition and destruction.