Prevention of spontaneous hepatocellular carcinoma in long‐evans cinnamon rats with hereditary hepatitis by th administration of d‐penicillamine
Kang Jong‐Hon, Yuji Togashi, Hiroshi Kasai, Masuo Hosokawa, Noritoshi Takeichi – 1 September 1993 – Acute hepatitis spontaneously develops in the Long‐Evans Cinnamon rat at the age of 4 mo, and eventually hepatocellular carcinoma develops after the chronic hepatitis that persists for over a year. Previously, abnormal copper accumulation was found in the livers of Long‐Evans Cinnamon rats from birth, and it was reported that short‐term administration of D‐penicillamine, a copper‐chelating agent, prevented acute hepatitis in Long‐Evans Cinnamon rats.