Masaharu Sakamoto, Takato Ueno, Motoaki Kin, Hiromasa Ohira, Takuji Torimura, Sadataka Inuzuka, Michio Sata, Kyuichi Tanikawa – 1 October 1993 – The contractile response of cultured Ito cells to endothelin‐1 and substance P was examined. Ito cells were obtained from rat liver by perfusion with collagenase, followed by separation through centrifugal elutriation, and were cultured for 24 hr. The area of the Ito cells was measured after treatment with endothelin‐1 or substance P at various concentrations in the culture medium.

Joshua Schafer, Mark S. D'Almeida, Harvey Weisman, W. Wayne Lautt – 1 October 1993 – Hepatic capacitance responses were compared in sham‐operated and 14‐day bile duct–ligated cats under pentobarbital anesthesia. Both groups were subjected to splenectomy and had the anterior hepatic nerve plexus sectioned to allow stimulation; the posterior plexus was intact. Blood volume compensation for hemorrhage was reduced in the bile duct ligation group compared with the control group: The liver compensated for 20.1% and 10.6% of blood loss, respectively.

1 September 1993

Nora B. Krull, Thomas Zimmermann, Axel M. Gressner – 1 September 1993 – Expression of the proteoglycans biglycan and decorin and of transforming growth factor‐α1 at various stages of liver fibrosis induced experimentally in rats by oral administration of thioacetamide was examined. Using in situ hybridization combined with immunocytochemical staining for cell‐type characteristic markers, we demonstrate spatial and temporal expression patterns specific for each of the genes.

Daniel L. B. Hill, Luis S. Marsano, Craig J. McClain – 1 September 1993 – Patients with alcoholic hepatitis often have hepatic polymorphonuclear leukocyte infiltration and neutrophilia. Interleukin‐8 is a cytokine that stimulates neutrophil chemotaxis and release of lysosomal enzymes. It is made by several types of cells, including fibroblasts, Kupffer cells and hepatocytes. In this study, serial plasma interleukin‐8 concentrations were measured with enzyme‐linked immunosorbent assay in 40 consecutive patients with moderate‐to‐severe alcoholic hepatitis over a 6‐mo period.

Mark Hathaway, David Burnett, Elwyn Elias, David H. Adams – 1 September 1993 – In 35 patients receiving first liver transplants we assessed the chemotactic responsiveness of peripheral blood lymphocytes to bile, the subset composition of the responding population and the ability of peripheral blood lymphocytes to produce chemotactic factors.

Raymond S. Koff – 1 September 1993

Julio Vorobioff, Eduardo Picabea, Marcelo Gamen, Roberto Villavicencio, Juan Bordato, Fernando Bessone, Hugo Tanno, Jorge Palazzi, Hector Sarano, Luisa Pozzoli, Roberto Sanchez, Ricardo Giordano – 1 September 1993 – The long‐term hemodynamic and renal effects of propranolol were compared with those of propranolol plus isosorbide dinitrate in 44 portal‐hypertensive alcoholic cirrhotic patients. Eight control patients, 8 patients receiving propranolol and 14 patients receiving propranolol plus isosorbide dinitrate were hemodynamically evaluated.

Germana V. Gregorio, Giorgina Mieli‐Vergani – 1 September 1993

Robert Cywes, Marian A. Packham, Linda Tietze, Juan R. Sanabria, P. Robert C. Harvey, M. James Phillips, Steven M. Strasberg – 1 September 1993 – Cold preservation of liver allografts injures hepatic sinusoidal lining cells. This injury is exacerbated on reperfusion, in part because of adhesion of leukocytes. Platelets also adhere to activated endothelial surfaces. In this study we examined the role of platelets in preservation injury.