1 September 1995

Michael F. Sorrell – 1 September 1995

Zbigniew K. Wszolek, Robert E. Steg – 1 September 1995

1 September 1995

1 September 1995

Stuart C. Gordon – 1 September 1995

Joseph Cascarano, Patricia A. Chambers, Eileen Schwartz, Parvoneh Poorkaj, Roy E. Gondo – 1 September 1995 – Our objective was to determine if mitochondrial‐rough endoplasmic reticulum (mt‐RER) associations provide for an ordered arrangement of mitochondria in the cell. If such an ordered arrangement exists, it might be manifested by grouping of mitochondria according to size and biochemical properties. Liver homogenate was subjected to rate zonal centrifugation for fractionating mitochondrial clusters. These clusters were then examined for morphological and biochemical characteristics.

Eelco F. M. Wijdicks – 1 September 1995

David J. Plevak – 1 September 1995 – This edition of “The Crucible” contains the first installment of what we hope will become an ongoing discussion of critical care issues in liver transplantation. After considering an agenda of salient critical care topics, we chose to inaugurate the Critical Care Forum with this discussion on neurological concerns. Intensivists, transplant surgeons, and others involved in the immediate postoperative care of liver transplant recipients generally do not expect a serious neurological setback after transplantation.

Linda S. Sher, Leonard Makowka – 1 September 1995 – Background. Tacrolimus (FK 506), a macrolide compound isolated from a bacterium, is a potent immuno‐suppressant with activity in solid‐organ transplants. Most immunosuppressive regimens for liver transplantation are based on cyclosporine.