Simon C. Robson, Delawir Kahn, J. Kruskal, Arthur R. Bird, Ralph E. Kirsch – 1 October 1993 – To assess the contribution of naturally occurring portal‐systemic shunts to the coagulopathy of patients with liver disease, we studied laboratory parameters of hemostasis in 20 adult patients with extrahepatic portal hypertension, secondary to portal vein thrombosis, that had resulted in variceal bleeding. All extrahepatic portal hypertension patients had normal liver function and histological appearance.

Jonathan M. Koff – 1 October 1993

Karin Vanderkerken, Luc Bouwens, Wilfried de Neve, Kit van den Berg, Marijke Baekeland, Nadia Delens, Eddie Wisse – 1 October 1993 – Liver sinusoids contain a population of large granular lymphocytes or natural killer cells, originally termed pit cells. After isolation and purification, these cells were separated into a low‐density and a high‐density fraction. The liver low‐density fraction differs significantly in morphology and function from cells of the blood, whereas the liver high‐density fraction shows intermediate properties.

Fumio Nomura, Masatoshi Noda – 1 October 1993 – ADP ribosylation is considered one of the important covalent modifications of cellular proteins catalyzed by ADP ribosyltransferase, which transfers ADP ribose moiety of NAD to an acceptor protein. Because a growing body of evidence has suggested significant biological roles for mono‐ADP ribosylations in transmembrane signal transduction and other cell metabolism, how alcohol intake alters them is of interest.

Louise Gariépy, Daphna Fenyves, Ibrahim Kassissia, Jean‐Pierre Villeneuve – 1 October 1993 – We studied the steady‐state hepatic extraction and single‐pass hepatic uptake of propranolol in isolated perfused livers from normal rats and compared these values with those of rats with carbon tetrachloride–induced cirrhosis, rats treated with chlorpromazine (an inhibitor of propranolol metabolism) and rats with acute liver injury.

Gregor Zöhrens, Thomas Armbrust, Ursula Pirzer, Karl‐Hermann Meyer zum Büschenfelde, Giuliano Ramadori – 1 October 1993 – To study the influence of chronic hepatitis on intercellular adhesion molecule‐1 serum concentration, we measured intercellular adhesion molecular‐1 in the serum of 84 patients with chronic liver disease (17 chronic persistent hepatitis, 42 chronic active hepatitis and 25 active cirrhosis) caused by hepatitis B virus (n = 46), hepatitis C virus (n = 10) and autoimmunity (n = 28).

Andrew Mason, Mark Wick, Heather White, Robert Perrillo – 1 October 1993 – Hepatitis B virus–specific nucleic acid sequences and proteins have been detected in extrahepatic tissues of acutely and chronically infected patients. However, apart from peripheral blood mononuclear cells and bone marrow cells, little is known about the specific cell types that permit viral replication. In this study, we assessed the extrahepatic tissues of four patients who died with chronic hepatitis B virus infection and two uninfected controls by means of in situ hybridization and immunohistochemical study.

Frank L. Iber – 1 October 1993

Ian R. Mackay – 1 October 1993

P. J. Johnson, Ian G. McFarlane, Convenors, On Behalf of the Panel – 1 October 1993