Urs A. Boelsterli, Armin Wolf, Christian Göldlin – 1 November 1993 – Cocaine ethyl ester (“cocaethylene”) is a cocaine metabolite formed by hepatic carboxylesterases in the presence of ethanol. In the human liver, this pharmacologically active cocaine analog may reach concentrations similar to those of cocaine.
Kevin M. Man, Anne Drejet, Emmet B. Keeffe, Richard Garcia‐Kennedy, Joanne C. Imperial, Carlos O. Esquivel – 1 November 1993 – Three patients with primary sclerosing cholangitis and Hodgkin's disease, a previously unrecognized association, are reported. All three patients were men, and one patient had Crohn's disease of the colon. Primary sclerosing cholangitis was diagnosed 2, 11 and 17 yr before diagnosis of Hodgkin's disease in the three patients, and all three had advanced biliary cirrhosis prompting referral for liver transplantation.
Erin G. Schuetz, John D. Schuetz, Stephen C. Strom, Melissa T. Thompson, Robert A. Fisher, David T. Molowa, Donna Li, Philip S. Guzelian – 1 November 1993 – The cytochrome P‐450 3A gene family comprises the dominant forms of cytochrome P‐450 found in human liver.
Haim Schupper, Paul Hayashi, James Scheffel, Sherri Acettuno, Teresa Paglieroni, Paul V. Holland, Jerome B. Zeldis – 1 November 1993 – Peripheral blood mononuclear cell proliferative responses in vitro to recombinant yeast or Escherichia coli hepatitis C virus fusion proteins were evaluated in 20 patients with chronic hepatitis C who were reactive for antibody to hepatitis C virus (on enzyme immunoassay, version 2.0, and a four‐antigen recombinant immunoblot assay). Twenty age‐matched, healthy individuals negative for antibody to hepatitis C virus were used as a control group.
Seiji Kawasaki, Masatoshi Makuuchi, Hidetoshi Matsunami, Yasuhiko Hashikura, Toshihiko Ikegami, Hisanao Chisuwa, Tatsuo Ikeno, Terumasa Noike, Tadatoshi Takayama, Hideo Kawarazaki – 1 November 1993 – Segmental liver volume determination by computed tomographic scan was carried out preoperatively in nine donors for living related liver transplantation. The calculated volume was compared with the graft size actually obtained by three types of donor hepatectomy. The volume of the left lateral segment (175 to 241 ml) and the left lobe (310 to 490 ml) varied markedly among the donors.
Jung‐Min Pak, Samuel S. Lee – 1 November 1993 – To clarify a possible pathogenic role for bile salts in the hyperdynamic circulation of cirrhosis, we studied the vasoactive effects of three different bile salts–tauroursodeoxycholic acid, taurochenodeoxycholic acid and taurodeoxycholic acid–in cirrhotic rats. Cirrhosis was induced with bile duct ligation; controls underwent sham surgery. In vivo, the bile salts were intravenously infused at one of three doses (1.2 × 10−7, 1.2 × 10−6 and 6.0 × 10−5 mol · 100 gm−1 · min−1) for 5 min.
Roger Lester, Piotr Zimniak – 1 November 1993 – Sodium‐dependent bile acid transport is a well‐established function of the sinusoidal segment of the hepatocyte plasma membrane. Evidence has been provided previously by the authors for the existence of a putative sinusoidal plasma membrane sodium‐dependent bile acid transporter with a mass of 49 kD. This protein has been partially characterized with a monoclonal antibody and by reconstitution in proteoliposomes. Further characterization is provided in the paper under discussion.
Jose J. G. Marin, Emilio R. Barbero, Maria C. Herrera, Arantxa Tabernero, Maria J. Monte – 1 November 1993 – Liver cell proliferation is a complex process that can be affected by a large number of factors such as bile acids, which have been reported to be associated to the pathogenesis of liver cancer. In this work, bile acid–induced modifications in DNA synthesis by regenerating perfused rat liver were investigated. Two‐thirds hepatectomy was carried out 24 hr before perfusion of livers with recirculating, erythrocyte‐free Krebs‐Henseleit solution.