Endothelins 1 and 3: Potent cholestatic agents secreted and excreted by the liver that interact with cyclosporine
Renata E. Bluhm, Marshall G. Frazer, Mary Vore, C. Wright Pinson, Kamal F. Badr – 1 October 1993 – Autoradiographic studies have shown that the liver accumulates endothelin. High‐affinity binding sites for endothelin have been identified on rat liver plasma membranes. We investigated the role of endothelin isopeptides as mediators of cholestasis with isolated rat liver perfused by a recirculating solution of buffer and blood.
Zonal distribution of protein‐acetaldehyde adducts in the liver of rats fed alcohol for long periods
Renee C. Lin, Feng C. Zhou, Michael J. Fillenwarth, Lawrence Lumeng – 1 October 1993 – Acetaldehyde, a highly reactive intermediate of alcohol metabolism, has been shown to form adducts with liver proteins in rats fed alcohol for long periods. In this report, the zonal distribution of liver proteinacetaldehyde adducts that formed in vivo was studied by means of histoimmunostaining. Rats were pair‐fed alcohol‐containing and alcohol‐free AIN'76 liquid diets for 2 or 11 wk before they were killed and subjected to whole body perfusion with paraformaldehyde.
Multiple‐dose pharmacokinetics of rufloxacin in patients with cirrhosis
David R. Triger, Fernando Granai, Jocelyn Woodcock, Richard Wise, Bruno P. Imbimbo – 1 October 1993 – The multiple‐dose pharmacokinetics of rufloxacin were investigated in 13 patients with biopsy‐proven cirrhosis and in 5 healthy controls. Rufloxacin was administered once a day for 5 consecutive days, starting with a loading dose of 400 mg on day 1 and 200 mg on the subsequent days. Plasma and urinary drug concentrations were determined by high‐performance liquid chromatography and a microbiological assay.
Notices
1 October 1993
What should we clinicians do for healthy, asymptomatic, hbsag‐positive carriers?
Brian J. McMahon – 1 October 1993 – Objective: To assess the long‐term outcome in hepatitis B surface antigen (HBsAg) carriers who have normal liver function tests, focusing on survival and the development of severe liver disease and hepatocellular carcinoma.
Chasing the escape mutant
Darius Moradpour, Jack R. Wands, Margherita Melegari – 1 October 1993
Lessons from the repression of the α‐fetoprotein gene in the adult liver
Bahri M. Bilir – 1 October 1993 – The developmental regulation of the α‐fetoprotein (AFP) gene in liver results in high‐level expression in the fetus, followed by dramatic transcriptional repression after birth. We have examined the mouse AFP gene for transcriptional control sequences that may be involved in its postnatal repression in liver.
Changes of serum 7S fragment of type IV collagen and N‐terminal propeptide of type III procollagen after transcatheter arterial embolization as a model of acute liver injury
Takeaki Suou, Sadako Yamada, Junko Kobayashi, Ushio Hoshino, Eiji Nishimuki, Hironaka Kawasaki – 1 October 1993 – To evaluate the mechanism of increased serum concentrations of the N‐terminal propeptide of type III procollagen and the 7S fragment of type IV collagen in acute liver injury, we serially measured serum levels of these substances after transcatheter arterial embolization in patients with hepatocellular carcinoma.
Extrahepatic peribiliary glands express α‐amylase isozymes, trypsin and pancreatic lipase: An immunohistochemical analysis
Tadashi Terada, Tetsuji Kida, Yasuni Nakanuma – 1 October 1993 – We examined expression of α‐amylase isozymes (pancreatic and salivary), trypsin and pancreatic lipase on the epithelium of extrahepatic peribiliary glands immunohistochemically using 53 autopsied normal extrahepatic bile ducts. Three parts of the extrahepatic bile duct (common bile duct, intrapancreatic bile duct and bile duct at the ampulla of Vater) were examined in each case. Histologically, the extrahepatic bile duct harbored branched tubular glands (extrahepatic peribiliary glands).