Kwang Hyub Han, F. Blaine Hollinger, Christine A. Noonan, Harvey Solomon, Goran B. G. Klintmalm, Robert M. Genta, Boris Yoffe – 1 November 1993 – To gain new insights into the pathogenesis of hepatitis B virus–induced chronic liver disease, we have used nonisotopic in situ detection methods for the simultaneous analysis of hepatitis B virus DNA and antigens at the single‐cell level.

Kazunori Aoki, Kenichi Takayasu, Toshinobu Kawano, Yukio Muramatsu, Noriyuki Moriyama, Fumihiko Wakao, Junji Yamamoto, Kazuaki Shimada, Tadatoshi Takayama, Tomoo Kosuge, Susumu Yamasaki, Michiie Sakamoto, Setsuo Hirohashi – 1 November 1993 – Clinicoradiological features were studied in 20 patients with 22 mass lesions of combined hepatocellular carcinoma and cholangiocarcinomas and findings of computed tomography in 12 of these patients with 14 hepatocellular carcinoma–cholangiocarcinomas. Five of these patients also had single overt hepatocellular carcinomas.

Roberto de Franchis, Paolo G. Arcidiacono, Luca Carpinelli, Bruno Andreoni, Lorenzo Cestari, Sergio Brunati, Alessandro Zambelli, Giorgio Battaglia, Pier M. Mannucci – 1 November 1993 – 1‐Deamino‐8‐D‐arginine vasopressin (DDAVP, desmopressin), a synthetic analog of the antidiuretic hormone L‐arginine vasopressin, improves hemostasis parameters in cirrhotic patients. Hence its use in combination with a vasoactive drug such as terlipressin might improve the performance of this drug in controlling variceal bleeding.

Arthur M. Magun – 1 November 1993

1 November 1993

Herbert Tilg, Wolfgang Vogel, Christian J. Wiedermann, Leland Shapiro, Manfred Herold, Gert Judmaier, Charles A. Dinarello – 1 November 1993 – The proinflammatory cytokines interleukin‐1 and tumor necrosis factor‐α are thought to play important roles in the pathophysiology of liver disease. Specific antagonists of these cytokines have been found in recent years. Interleukin‐1 receptor antagonist is a specific interleukin‐1 antagonist.

Dana Liang, Bruno Hagenbuch, Bruno Stieger, Peter J. Meier – 1 November 1993 – We investigated the molecular mechanism underlying the progressive loss of Na+ ‐dependent bile salt uptake in primary cultured rat hepatocytes. A specific cDNA probe was used to quantitate the levels of mRNA encoding the Na+ ‐taurocholate–cotransporting polypeptide at various culture times. Hepatocytes were cultured on collagen in the presence of insulin (10−7 mol/L), dexamethasone (10−7 mol/L) and 10% fetal calf serum for up to 72 hr.

Gilles Lesur, Philippe Levy, Jean‐François Flejou, Jacques Belghiti, François Fekete, Pierre Bernades – 1 November 1993 – In the course of alcoholic chronic pancreatitis, increased serum alkaline phosphatase level is usually caused by common bile duct stenosis but may also be due to alcoholic liver disease. The aims of this prospective study were to investigate whether clinical, biochemical and radiological factors could predict liver histopathological appearance.

Harushige Nakatsukasa, Jeffrey A. Silverman, Timothy W. Gant, Ritva P. Evarts, Snorri S. Thorgeirsson – 1 November 1993 – We analyzed expression of multidrug resistance (mdr) genes in rat liver during regeneration after partial hepatectomy or carbon tetrachloride–induced necrosis. In situ hybridization revealed that in the normal liver the cellular distribution of mdr transcripts and protein is restricted to hepatocytes and that a gradient, highest in zone 1 and lowest in zone 3, exists in the level of the mdr transcripts in the liver acinus.

Samy A. Azer, Michael Murray, Geoffrey C. Farrell, Neill H. Stacey – 1 November 1993 – Because some patients with cirrhosis have serum transaminase levels within the normal range, a prospective study was undertaken to determine whether the concentration of individual serum bile acids would be a sensitive indicator of development of cirrhosis. The choline‐deficient rat has been used as a model for study of these changes. Using high‐performance liquid chromatography, we measured the concentrations of individual serum bile acids at 3, 6, 10, 20 and 30 wk of dietary intake.