Combined hepatocellular carcinoma and cholangiocarcinoma: Clinical features and computed tomographic findings

Kazunori Aoki, Kenichi Takayasu, Toshinobu Kawano, Yukio Muramatsu, Noriyuki Moriyama, Fumihiko Wakao, Junji Yamamoto, Kazuaki Shimada, Tadatoshi Takayama, Tomoo Kosuge, Susumu Yamasaki, Michiie Sakamoto, Setsuo Hirohashi – 1 November 1993 – Clinicoradiological features were studied in 20 patients with 22 mass lesions of combined hepatocellular carcinoma and cholangiocarcinomas and findings of computed tomography in 12 of these patients with 14 hepatocellular carcinoma–cholangiocarcinomas. Five of these patients also had single overt hepatocellular carcinomas.

Southern‐blot analysis and simultaneous In Situ detection of hepatitis B virus–associated DNA and antigens in patients with end‐stage liver disease

Kwang Hyub Han, F. Blaine Hollinger, Christine A. Noonan, Harvey Solomon, Goran B. G. Klintmalm, Robert M. Genta, Boris Yoffe – 1 November 1993 – To gain new insights into the pathogenesis of hepatitis B virus–induced chronic liver disease, we have used nonisotopic in situ detection methods for the simultaneous analysis of hepatitis B virus DNA and antigens at the single‐cell level.

Endothelins 1 and 3: Potent cholestatic agents secreted and excreted by the liver that interact with cyclosporine

Renata E. Bluhm, Marshall G. Frazer, Mary Vore, C. Wright Pinson, Kamal F. Badr – 1 October 1993 – Autoradiographic studies have shown that the liver accumulates endothelin. High‐affinity binding sites for endothelin have been identified on rat liver plasma membranes. We investigated the role of endothelin isopeptides as mediators of cholestasis with isolated rat liver perfused by a recirculating solution of buffer and blood.

Zonal distribution of protein‐acetaldehyde adducts in the liver of rats fed alcohol for long periods

Renee C. Lin, Feng C. Zhou, Michael J. Fillenwarth, Lawrence Lumeng – 1 October 1993 – Acetaldehyde, a highly reactive intermediate of alcohol metabolism, has been shown to form adducts with liver proteins in rats fed alcohol for long periods. In this report, the zonal distribution of liver proteinacetaldehyde adducts that formed in vivo was studied by means of histoimmunostaining. Rats were pair‐fed alcohol‐containing and alcohol‐free AIN'76 liquid diets for 2 or 11 wk before they were killed and subjected to whole body perfusion with paraformaldehyde.

Multiple‐dose pharmacokinetics of rufloxacin in patients with cirrhosis

David R. Triger, Fernando Granai, Jocelyn Woodcock, Richard Wise, Bruno P. Imbimbo – 1 October 1993 – The multiple‐dose pharmacokinetics of rufloxacin were investigated in 13 patients with biopsy‐proven cirrhosis and in 5 healthy controls. Rufloxacin was administered once a day for 5 consecutive days, starting with a loading dose of 400 mg on day 1 and 200 mg on the subsequent days. Plasma and urinary drug concentrations were determined by high‐performance liquid chromatography and a microbiological assay.

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