Ulrich Marti – 1 December 1993 – In the aged liver, cell proliferation and induction of DNA synthesis by epidermal growth factor is impaired. Changes in the hepatic handling of epidermal growth factor may be important for these effects. I compared epidermal growth factor handling in the livers of young and old rats. Epidermal growth factor binding capacity of plasma membranes was reduced from 1.30 ± 0.15 to 0.51 ± 0.19 pmol/mg in young and old animals, respectively.

Janet Quinn, Austin G. Diamond, Jeremy M. Palmer, Margaret F. Bassendine, Oliver F. W. James, Stephen J. Yeaman – 1 December 1993 – Approximately 95% of patients with primary biliary cirrhosis have antimitochondrial antibodies against the E2 component of the pyruvate dehydrogenase complex (E2p). Immunodominant sites on E2p have been localized to the inner lipoyl domain, which serves as a covalent attachment site for the essential cofactor, lipoic acid. However, it is not clear whether the presence of lipoic acid is necessary for autoimmune recognition of human E2p.

Giorgio Saracco, Floriano Rosina, Maria Lorena Abate, Livio Chiandussi, Vittorio Gallo, Elena Cerutti, Angelo Di Napoli, Antonio Solinas, Angelo Deplano, Andreina Tocco, Pierangela Cossu, David Chien, George Kuo, Alan Polito, Amy J. Weiner, Michael Houghton, Giorgio Verme, Ferruccio Bonino, Mario Rizzetto – 1 December 1993 – Eighty patients with chronic hepatitis C who completed a previously reported randomized controlled trial on the efficacy of interferon‐α2b were followed up for at least 36 mo after therapy discontinuation.

Carl T. McGary, Judith Yannariello‐Brown, Dennis W. Kim, Tami C. Stinson, Paul H. Weige – 1 December 1993 – The release and intracellular accumulation of 125I‐hyaluronan degradation products was studied in cultured liver endothelial cells with hyaluronan oligosaccharides (relative molecular mass = approximately 44,000) uniquely modified and radiolabeled at the terminal reducing sugar. Two methods were combined to measure 125I‐hyaluronan degradation by liver endothelial cells.

Stuart C. Gordon, Richard S. Elloway, John C. Long, Carl F. Dmuchowski – 1 December 1993 – We reviewed the clinical records of 140 consecutively evaluated patients with chronic hepatitis C infection. One hundred twenty‐four patients (89%) contracted infection through blood transfusion or intravenous drug use. The liver biopsy specimens of 83 patients (43 blood transfusion cases and 40 intravenous drug abuse cases) were examined without knowledge of the mode of disease transmission.

Andreas Gardemann, Thomas Zimmermann, Georg Machnik, Rolf Dargel, Kurt Jungermann – 1 December 1993

Vijayan Balan, Kennetii P. Batts, Michael K. Porayko, Ruud A. F. Krom, Jurgen Ludwig, Russell H. Wiesner – 1 December 1993 – Whether primary biliary cirrhosis recurs after orthotopic liver transplantation remains a controversial issue. Sixty consecutive patients with primary biliary cirrhosis with at least 1 yr of follow‐up after liver transplantation were studied. All patients were treated with triple‐drug immunosuppression (cyclospoine, prednisone, azathioprine).

Yves M. Deugnier, Paul Charalambous, Daniéle Le Quilleuc, Bruno Turlin, Jeffrey Searle, Pierre Brissot, Lawrie W. Powell, June W. Halliday – 1 December 1993 – Sublobular nodules of hepatocytes free of iron or exhibiting much less iron than the surrounding parenchyma, referred to in this study as iron‐free‐foci, are frequently found in the livers of patients with genetic hemochromatosis complicated by hepatocellular carcinoma.

1 November 1993

Winita Hardikar, Frederick J. Suchy – 1 November 1993 – Transport systems involved in uptake and biliary secretion of bile salts have been extensively studied in rat liver; however, little is known about these systems in the human liver. In this study, we investigated taurocholate (TC) transport in canalicular and basolateral plasma membrane vesicles isolated from 15 human livers (donor age 6–64 yr). ATP stimulated the uptake of TC into both canalicular and basolateral human liver plasma membrane vesicles (cLPM and bILPM, respectively).