Gene expression of N‐acetylglucosaminyltransferases III and V: A possible implication for liver regeneration

Elji Miyoshi, Yoshito Ihara, Atsushi Nishikawa, Hiroyuki Saito, Naofumi Uozumi, Norio Hayashi, Hideyuki Fusamoto, Takenobu Kamada, Naoyuki Taniguchi – 1 December 1995 – N‐acetylglucosaminyltransferases III and V (GnT‐III and ‐V) are key enzymes in the synthesis of the branches of asparagine‐linked oligosaccharides. Although their messenger RNAs (mRNAs) are expressed in various rat tissues, they are not detected in normal rat liver. Expression of the GnT‐III and ‐V mRNAs, however, increased in regenerating liver after two‐thirds partial hepatectomy compared with sham‐operated rats.

Blunted natriuretic response to low‐dose brain natriuretic peptide infusion in nonazotemic cirrhotic patients with ascites and avid sodium retention

Giorgio La Villa, Donato Riccardi, Chiara Lazzeri, Vincenzo Casini Raggi, Antonio Dello Sbarba, Cristina Tosti Guerra, Caterina Fronzaroli, Marco Foschi, Giacomo Laffi, Paolo Gentilini – 1 December 1995 – Patients with cirrhosis and ascites have high plasma levels of atrial (ANP) and brain (BNP) natriuretic peptides, two cardiac hormones released by the atria and ventricles, respectively.

Specific targeting of human hepatocellular carcinoma cells by immunoliposomes in vitro

Darius Moradpour, Béatrice Compagnon, Byron E. Wilson, Claude Nicolau, Jack R. Wands – 1 November 1995 – The monoclonal antibody AF‐20 was raised against the human hepatocellular carcinoma (HCC) cell line FOCUS and binds with high affinity to a rapidly internalized 180‐kd homodimeric glycoprotein that is abundantly expressed on the surface of human HCC and other human cancer cell lines. Immunoliposomes were produced by covalently coupling AF‐20 to liposomes containing carboxyfluorescein.

Progressive multifocal leukoencephalopathy after orthotopic liver transplantation

David J. Bronster, Mika W. Lidov, David Wolfe, Myron E. Schwartz, Charles M. Miller – 1 November 1995 – Six weeks after liver transplantation, a 51‐year‐old man developed a slowly progressive hemiparesis with deteriorating mental status and seizures. Successive computed tomography (CT) scans of the brain revealed unilateral nonenhancing white matter lucencies that gradually coalesced and progressed to both hemispheres. Brain biopsy results were consistent with progressive multifocal leukoencephalopathy (PML).

Endothelin and vascular reactivity in cirrhosis

Cornel C. Sieber – 1 November 1995 – Background/Aims: Because the vasodilator nitric oxide is overproduced in cirrhosis, this substance may decrease pressor responses to the vasoconstrictor endothelin 1. This study aimed to examine the effects of a NO synthesis inhibitor (NG‐nitro‐L‐arginine methyl ester; L‐NAME) on vascular responsiveness to endothelin 1 in normal and cirrhotic rats. Methods: Pressor dose‐response curves to endothelin 1 (0.5, 1, 3, 6, and 10 μg/kg intravenously) were obtained in animals with or without pretreatment with L‐NAME.

Failure of liver transplantation to diminish cardiac deposits of amylopectin and leukocyte inclusions in type iv glycogen storage disease

Philip Rosenthal, Luis Podesta, Robert Grier, Jonathan W. Said, Linda Sher, Jose Cocjin, Frederick Watanabe, Eric Vasiliauskas, Robert Van De Velde, Leonard Makowka – 1 November 1995 – Orthotopic liver transplantation has been used to treat glycogen storage disease type IV. Most long‐term surviving patients who have undergone liver transplantation have been free of neuromuscular and cardiac morbidity, and regression of cardiac amylopectin infiltration has been reported after liver transplantation. Leukocyte inclusions in glycogen storage disease type IV have also been reported.

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