M. Sawkat Anwer – 1 August 1993 – Calcium ionophores such as ionomycin and A23187 are often used to determine the role of intracellular Ca+ + in cellular processes. Ionomycin but not Ca+ +‐mobilizing agonists increases basal intracellular pH in hepatocytes. To explain this difference in effects of agents that increase intracellular Ca+ + concentration, the mechanism of ionomycin‐induced increases in basal intracellular pH in isolated rat hepatocytes was studied.

Raymond S. Koff, Jean‐Francois Dufour, Irwin M. Arias – 1 August 1993

Alexander S. Petrides, Dirk Schulze‐Berge, Christoph Vogt, Dwight E. Matthews, Georg Strohmeye – 1 August 1993 – Insulin resistance is a characteristic feature of glucose‐intolerant and diabetic cirrhotic patients. The pathogenic factors, however, that are responsible for the development of impaired glucose tolerance in cirrhosis, remain unclear.

Anna Castro, Wladimiro Jiménez, Joan Clária, Josefa Ros, Josep Maria Martínez, Marta Bosch, Vicente Arroyo, Jaume Piulats, Francisca River, Joan Rodés – 1 August 1993 – Impaired vascular responsiveness to angiotensin II is a common feature in human cirrhosis with ascites. The aim of this study was to investigate whether vascular reactivity to angiotensin II is also decreased in rats with carbon tetrachloride–induced cirrhosis and ascites and to assess the role of endogenous nitric oxide in this abnormality.

Hector Orrego, Frederick J. Carmichael, Masahide Oshita, Yoshiyuki Takei, Sunao Kawano, Hideyuki Fusamoto, Takenobu Kamada – 1 August 1993

1 August 1993

Frederick J. Carmichael, Hector Orrego, Victor Saldivia, Yedy Israel – 1 August 1993 – It has been postulated that the beneficial effects of the antithyroid drug propylthiouracil in the treatment of alcoholic liver disease depend primarily on the action of propylthiouracil in suppressing the increase in hepatic oxygen consumption induced by ethanol. The evidence for this effect of propylthiouracil is derived from studies in which liver oxygen consumption has been determined in in vitro preparations.

Antonio Benedetti, Luca Marucci, Cristina Bassotti, Raniero Mancini, Susanna Contucci, Anne Marie Jezequel, Francesco Orland – 1 August 1993 – Morphometric ultrastructural analysis of horseradish peroxidase–containing structures has been performed in vivo, in rat liver and, in vitro, in isolated bile ducts to determine whether a transcytotic vesicle pathway exists in biliary epithelial cells. In vivo, horseradish peroxidase (100 mg/kg body wt) was given by intraportal injection in normal rats (n = 15) or 1 hr after administration of 600 mg/kg valproic acid (n = 15).

Chris J. Dickinson, Alan Olson – 1 August 1993 – Objective: To determine clinical and economic consequences of alternative vaccination strategies for preventing hepatitis B virus infection (HBV).

Robert L. Hamilton, Richard J. Havel – 1 August 1993 – In the study reported by Wetterau et al., a recently characterized heterodimeric protein called microsomal triglyceride transfer protein was undetectable on immunoblotting of samples from intestinal biopsies of human subjects with the genetic disorder abetalipoproteinemia. With only one fourth to one fifth the soluble proteins of homogenized intestinal biopsy specimens of normal human subjects and patients with different fat‐absorption defects, the 88‐kD subunit of microsomal triglyceride transfer protein was clearly detectable.