Jorge J. Gumucio, W. Michael McDonnell – 1 September 1993 – Cytotoxic T lymphocytes (CTLs) specific for conserved viral antigens can respond to different strains of virus, in contrast to antibodies, which are generally strain‐specific. The generation of such CTLs in vivo usually requires endogenous expression of the antigen, as occurs in the case of virus infection.
Gabriele Missale, John J. Brems, Howard Takiff, Paul J. Pockros, Francis V. Chisari – 1 September 1993 – The proliferative response of peripheral blood lymphocytes to the HBcAg was compared with serological, molecular and immunohistochemical parameters of hepatitis B virus infection and with biochemical and histological parameters of liver disease in a patient who received a completely human leukocyte antigen class I‐mismatched liver allograft for fulminant hepatitis.
Fabio Tarsetti, Renato Lenzi, Roberto Salvi, Ekkehard Schuler, Koshilya Rijhsinghani, Romana Lenzen, Nicola Tavoloni – 1 September 1993 – In an attempt to clarify the role of oval cells in the emergence of hepatocellular carcinoma, we fed rats a choline‐free diet containing 0%, 0.05% or 0.1% ethionine. The incidence and nature of premalignant and malignant hepatic lesions were then related to the degree of oval cell proliferation.
Anna S. F. Lok, David Chien, Qui‐Lim Choo, Tak‐Mao Chan, Edmond K. W. Chiu, Ignatius K. P. Cheng, Michael Houghton, George Kuo – 1 September 1993 – Some immunosuppressed patients with hepatitis C virus infection do not have detectable levels of antibody to hepatitis C virus on second‐generation enzyme immunoassay. Antibodies to the envelope and nonstructural region 5 proteins have not been examined.
Tadashi Terada, Yasuni Nakanuma – 1 September 1993 – We investigated the development of human intrahepatic peribiliary capillary plexus by lectin‐histochemistry and immunohistochemistry, using 40 fetal livers of various gestational ages, 52 postnatal livers of various ages, and 10 adult livers.
Marcus K. H. Auth, Raymond A. Keitzer, Martin Scholz, Roman A. Blaheta, E. Christoph Hottenrott, Günther Herrmann, Albrecht Encke, Bernd H. Markus – 1 September 1993 – Biliary epithelial cells are a primary site of damage in liver allograft rejection and in immunologically mediated diseases such as primary biliary cirrhosis. Human leukocyte antigens and adhesion molecules on the biliary epithelium are associated with T‐lymphocytic binding, recognition and destruction.
Martin Volkmann, Martina Müller, Walter J. Hofmann, Martina Meyer, Jens Hagelstein, Ulrich Räth, Burkhard Kommerell, Hanswalter Zentgraf, Peter R. Galle – 1 September 1993 – Recently, p53 gene aberrations have been recognized as a relevant factor in hepatocarcinogenesis, in tumors from both high‐risk and low‐risk areas. Because p53 gene mutations typically result in increased p53 levels in tumor cells, this cellular protein might become immunogenic during tumor development.
Raimund Kaserbacher, Theresa Propst, Albert Propst, Ivo Graziadei, Gert Judmaier, Wolfgang Vogel – 1 September 1993
Peter H. McGuinness, G. Alex Bishop, Alfred Lien, Brenton Wiley, Carolyn Parsons, Geoffrey W. McCaughan – 1 September 1993 – Approximately 90% of subjects with chronic hepatitis resulting from hepatitis C virus infection have hepatitis C virus RNA in serum. However, the prevalence of hepatitis C virus RNA in serum from subjects with hepatitis C virus antibody associated with persistent normal liver biochemical values is unclear. Do these subjects have resolved or continuing infection with hepatitis C virus?
Yasuni Nakanuma – 1 September 1993 – Primary biliary cirrhosis is characterized by the immune‐mediated, nonsuppurative destruction of intrahepatic small bile ducts, with significant T‐cell involvement. To date, B cells in livers of primary biliary cirrhosis patients have been ignored in immunopathological evaluations of nonsuppurative cholangitis. This study aimed to correlate the distribution of activated T and B cells with the histopathology of nonsuppurative cholangitis in primary biliary cirrhosis, with emphasis on B cell infiltration.