Transforming growth factor‐β1 regulates platelet‐derived growth factor receptor β subunit in human liver fat‐storing cells

Massimo Pinzani, Alessandra Gentilini, Alessandra Caligiuri, Raffaella De Franco, Giulia Pellegrini, Stefano Milani, Fabio Marra, Paolo Gentilini – 1 January 1995 – Activated liver fat‐storing cells (FSC) are known to play a key role in the development of liver fibrosis. An important element in FSC activation process is the increased expression of receptors for platelet‐derived growth factor (PDGF), a potent mitogen for FSC.

Acute cellular rejection after liver transplantation: Variability, morbidity, and mortality

Laurel R. Fisher, Keith S. Henley, Michael R. Lucey – 1 January 1995 – Acute cellular rejection of the allograft is a potentially serious complication after liver transplantation, yet its true incidence is unknown. We therefore investigated the frequency of acute cellular rejection reported by transplant centers and its impact on morbidity and mortality. Morbidity was defined as duration of hospitalization. Of 200 articles screened, 18 were selected for inclusion in the study database, in which there was a total of 1,437 patients who received transplants.

Early cellular rejection after orthotopic liver transplantation correlates with low concentrations of FK506 in hepatic tissue

William J. Sandborn, George M. Lawson, Timothy J. Cody, Michael K. Porayko, J. Eileen Hay, Gregory J. Gores, Jeffery L. Steers, Ruud A. F. Krom, Russell H. Wiesner – 1 January 1995 – We have previously reported that low hepatic tissue cyclosporine levels correlate with early cellular rejectionafter liver transplantation. The aim of this study is to determine whether there is a similar relationship in patients treated with FK506.

Severe or multiple rejection episodes are associated with early recurrence of hepatitis C after orthotopic liver transplantation

Patricia A. Sheiner, Myron E. Schwartz, Eytan Mor, Leona K. Schluger, Neil Theise, Keiji Kishikawa, Vadim Kolesnikov, Henry Bodenheimer, Sukru Emre, Charles M. Miller – 1 January 1995 – Recurrent hepatitis C causes significant morbidity after liver transplantation. Because immunosuppression is associated with enhanced viral replication, we postulated that clinical recurrence of the disease may be associated with augmented immunosuppression for rejection.

Grading of cellular rejection after orthotopic liver transplantation

Siddhartha Datta Gupta, Mark Hudson, Andrew K. Burroughs, Richard Morris, Keith Rolles, Peter Amlot, Peter J. Scheuer, Amar P. Dhillon – 1 January 1995 – All 684 post‐orthotopic liver transplantation (OLT) liver biopsies performed at the Royal Free Hospital (RFH) between 1988 and 1993, from 120 patients, were reviewed in order to try to define the relative importance of the histological features of immunosuppressionresponsive cellular rejection.

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