Expression of SPARC in normal and fibrotic livers

Edward Frizell, Shu‐Ling Liu, Ann Abraham, Iwata Ozaki, Mahboubeh Eghbali, E. Helene Sage, Mark A. Zern – 1 March 1995 – SPARC (secreted protein, acidic and rich in cysteine)—also known as osteonectin, BM‐40, and 43K glycoprotein—is secreted by endothelial cells and fibroblasts in response to culture shock. SPARC has been found in association with tissues undergoing cell proliferation, migration, and extracellular matrix remodeling. We demonstrate that normal livers from humans, rats, and mice express substantial levels of SPARC messenger RNA (mRNA).

Lipoproteins and the liver sieve: The role of the fenestrated sinusoidal endothelium in lipoprotein metabolism, atherosclerosis, and cirrhosis

Robin Fraser, Bruce R. Dobbs, George W. T. Rogers – 1 March 1995 – The liver sieve, formed by the fenestrated hepatic sinusoidal endothelium, is a dynamic biofilter separating the hepatic blood from the plasma within the space of Disse. It filters macromolecules of differing sizes, especially lipoproteins. More specifically, it acts as a barrier to the large triglyceride‐rich parent chylomicrons, while permitting the smaller triglyceride‐depleted but cholesterol‐ and retinol‐rich remnants to enter the space of Disse.

CA19‐9 Does Not Predict cholangiocarcinoma in Patients With Primary Sclerosing Cholangitis Undergoing Liver Transplantion

Adrian Fisher, Neil D. Theise, Albert Min, Eytan Mor, Sukru Emre, Adam Pearl, Myron E. Schwartz, Charles M. Miller, Patricia A. Sheiner – 1 March 1995 – The results of liver transplantation in patients with cholangiocarcinoma have been poor. It has been suggested that elevated serum CA19‐9 levels predict cholangiocarcinoma in patients with primary sclerosing cholangitis. We analyzed the predictive value of CA19‐9 antigen as a marker of cholangiocarcinoma in patients with primary sclerosing cholangitis evaluated for liver transplantation.

Mapping of immunodominant CD4+ T lymphocyte epitopes of hepatitis C virus antigens and their relevance during the course of chronic infection

Robert M. Hoffmann, Helmut M. Diepolder, Reinhart Zachoval, Franz‐Maximilian Zwiebel, Maria‐Christina Jung, Siegfried Scholz, Hans Nitschko, Gert Riethmüller, Gerd R. Pape – 1 March 1995 – In acute and chronic viral disease the specific response of CD4+ T lymphocytes to certain viral proteins is an essential part of antiviral effector mechanisms. In hepatitis C virus infection, the contribution of the immune system and particularly of CD4+ T lymphocytes to the pathogenesis of disease is unknown.

Two different dosages of cefotaxime in the treatment of spontaneous bacterial peritonitis in cirrhosis: Results of a prospective, randomized, multicenter study

Antoni Rimola, Joan M. Salmerón, Gerardo Clemente, Luis Rodrigo, Antoni Obrador, M. Luisa Miranda, Carlos Guarner, Ramon Planas, Ricard Solá, Victor Vargas, Fernando Casafont, Francesc Marco, Miquel Navasa, Rafael Bañares, Vicente Arroyo, Joan Rodés – 1 March 1995 – Cefotaxime (CTX) is considered one of the first‐choice antibiotics in the therapy of spontaneous bacterial peritonitis (SBP) in cirrhosis. Because CTX is largely metabolized in the liver, this drug may also be effective in SBP by administering lower doses than those habitually used.

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