Liliane Dubuisson, Liliane Boussarie, Christiane‐Alexine Bedin, Charles Balabaud, Paulette Bioulac‐Sage – 1 March 1995 – The oral administration of selenium (Se) to young rats induces, over a 2‐month period, the formation of nodular regenerative hyperplasia with sinusoidal damage around nodules. Perinodular areas located in zone 1 comprise atrophic hepatocytes and capillarized sinusoids without fibrosis.

Doug Routley, John K. Ramage, James McPeake, Kai‐Chah Tan, Roger Williams – 1 March 1995 – The place of orthotopic liver transplantation (OLT) in the management of metastatic hepatic neuroendocrine tumors has not been adequately defined. The present report is concerned with patient survival, disease recurrence, and symptom relief in 11 such patients in a single center who, at the time of transplantation, had no extrahepatic tumor.

John K. Ramage, Susan M. Catnach, Roger Williams – 1 March 1995

Germán Soriano, Pere Coll, Carlos Guarner, José Such, Ferran Sánchez, Guillem Prats, Francisco Vilardell – 1 March 1995 – Spontaneous bacterial peritonitis (SBP) is a frequent and severe complication of cirrhosis. Escherichia coli is the most frequent bacterium isolated in this condition. The presence of capsular antigens, mainly the K1 capsular polysaccharide, has been associated with invasiveness in E coli infections. Capsular serotypes of E coli causing SBP were determined in 37 cirrhotic patients.

John G. Lee, Stephen M. Schutz, Ruth E. England, Joseph W. Leung, Peter B. Cotton – 1 March 1995 – The efficacy of endoscopic treatment in primary sclerosing cholangitis has not been clearly established. This report presents endoscopic intervention in 53 consecutive patients with this disorder. Pertinent data were abstracted from the GI‐TRAC database, medical records, and cholangiograms, and clinical follow‐up was obtained by telephone interview of the subjects. Assessed treatment outcomes were clinical symptom, liver function test, and cholangiographic appearance.

Adolfo Francesco Attili, Adriano de Santis, Rita Capri, Anna Maria Repice, Silvana Maselli, Grepco Group – 1 March 1995 – During the cross‐sectional studies (February 1981 to July 1984) performed by the Group for Epidemiology and Prevention of Cholelithiasis (GREPCO) in Rome, Italy, 161 subjects were identified as having gallstones. Ten subjects did not participate in the prospective follow‐up. At entry, 33 of the 151 remaining subjects were symptomatic, and 118 were asymptomatic.

Shao‐Nan Huang, Francis V. Chisari – 1 March 1995 – Hepatocyte turnover rates were studied in two lineages of transgenic mice that overproduce the hepatitis B virus (HBV) large envelope protein and retain filamentous hepatitis B surface antigen (HBsAg) particles in the endoplasmic reticulum, resulting in the formation of ground glass hepatocytes. The high producer lineage (50‐4) develops a necroinflammatory liver disease that progresses to hepatocellular carcinoma (HCC), whereas the low producer lineage (107‐5) displays no histopathologic changes other than ground glass hepatocytes.

Tetsuo Takehara, Norio Hayashi, Yasuhide Miyamoto, Masato Yamamoto, Eiji Mita, Hideyuki Fusamoto, Takenobu Kamada – 1 March 1995 – The lack of a small animal model of hepatitis C virus (HCV) infection has impeded elucidation of the pathogenesis of HCV. The aim of this study was to develop an HCV‐expressing animal model by means of cationic liposome‐mediated in vivo gene transfer.

Prodromos Hytiroglou, Neil D. Theise, Myron Schwartz, Eytan Mor, Charles Miller, Swan N. Thung – 1 March 1995 – Macroregenerative nodules (MRNs), probably representing a pathway for human hepatocarcinogenesis, are generally classified into type I MRNs (or ordinary adenomatous hyperplasia) and type II MRNs (or atypical adenomatous hyperplasia), on the basis of imprecise definitions of cytological and architectural atypia.

Raymond S. Koff – 1 March 1995