Systemic hemodynamic, forearm vascular, renal, and humoral responses to sustained cardiopulmonary baroreceptor deactivation in well‐compensated cirrhosis

Florence Wong, Alexander Logan, Laurence Blendis – 1 March 1995 – The aim of this study was to assess baroreceptor function in well‐compensated cirrhosis by determining the forearm vascular, renal, and humoral responses to sustained baroreceptor deactivation. The effect of sodium status on baroreceptor function was also assessed. Eight cirrhotic patients and 10 age‐ and sex‐matched controls were studied twice after a 20 mmol and 200 mmol of sodium/d diet for 7 days.

Metastatic endocrine tumors: Is there a place for liver transplantation?

Bertrand Dousset, Didier Houssin, Olivier Soubrane, Olivier Boillot, François Baudin, Yves Chapuis – 1 March 1995 – The authors describe their experience with liver transplantation (OLT) for metastatic endocrine tumors (MET) in order to determine reasonable indications for OLT in patients with this disease. Removal of the primary lesion and subsequent liver transplantation were performed in two separate procedures in all patients except one.

Differential patterns of reaction of human natural antibodies to pig hepatocytes and vascular endothelium

Hikaru Fujioka, Donald V. Cramer, Chikao Yasunaga, Phillip J. Tuso, Guo‐Du Wu, Yvette Middleton, Albert D. Moscioni, Jacek Rozga, Achilles A. Demetriou, Leonard Makowka – 1 March 1995 – We have recently conducted a series of experiments to characterize the pattern of reaction of human natural antibodies (NA) with individual pig liver cells.

Therapeutic serum concentrations of human alpha‐1‐antitrypsin after adenoviral‐mediated gene transfer into mouse hepatocytes

Mark A. Kay, Frank Graham, Frances Leland, Savio L. C. Woo – 1 March 1995 – Alpha‐1‐antitrypsin is a relatively common genetic deficiency that results in early emphysema. The liver as the natural source of most alpha‐1‐antitrypsin synthesis was the target organ selected for gene replacement therapy studies. Previous work used recombinant retroviral vectors that encode the human alpha‐1‐antitrypsin cDNA for ex vivo and direct in vivo transduction of hepatocytes in dogs and rodents. This approach led to low levels of the human protein in the serum of recipients.

Incidence of hepatocellular carcinoma in chronic hepatitis B and C: A prospective study of 251 patients

Susumu Takano, Osamu Yokosuka, Fumio Imazeki, Masami Tagawa, Masao Omata – 1 March 1995 – The incidence of hepatocellular carcinoma (HCC) was prospectively studied in 251 chronic hepatitis patients, and was compared between the 127 cases of hepatitis B and 124 cases of hepatitis C. All patients were diagnosed by needle biopsy on entering the study, and the cases consisted of chronic persistent hepatitis (CPH), chronic active hepatitis (CAH)2a, and CAH2b (cirrhosis was not included).

Is hepatitis B virus smarter than the immune system?

Marion Peters – 1 March 1995 – It has been suggested that mutations within immunodominant cytotoxic T‐lymphocyte (CTL) epitopes may be exploited by viruses to evade protective immune responses critical for clearance.1–4 Viral escape could originate from passive mechanisms, such as mutations within curcial CTL epitopes, either affecting major histocompatibility complex binding or T‐cell antigen receptor (TCR) recognition.

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