Tania Roskams, Han Moshage, Rita de Vos, David Guido, Paul Yap, Valeer Desmet – 1 April 1995 – Because increasing evidence implicates heparan sulfate proteoglycans (HSPGs) as essential cofactors in receptor‐growth factor interactions, in cell‐cell recognition systems, and in cell‐matrix adhesion processes and yet little is known about their cellular distribution pattern and cellular sources in liver tissue, we used monoclonal antibodies specific for the core proteins of syndecan1, 2, 3, 4, glypican, and perlecan to investigate their immunohistochemical expression in normal adult human liver

Donna L. Waters, Stuart F. A. Dorney, Margie A. Gruca, Hugh C. O. Martin, Robert Howman‐Giles, Alex E. Kan, Merl de Silva, Kevin J. Gaskin – 1 April 1995 – Focal and multilobular biliary cirrhosis are considered pathognomonic of cystic fibrosis (CF) and almost invariably have been reported in patients with steatorrhea. In contrast, patients with pancreatic sufficiency and normal absorption are considered less likely to develop liver or biliary tract problems.

Scott L. Friedman – 1 April 1995 – Background/Aims: Liver fibrosis and cirrhosis represent common pathological findings in humans with iron overload. This study was undertaken to assess whether in vivo targeting of iron to liver parenchymal or nonparenchymal cells would differently affect collagen gene activity. Methods: Rats were treated with an iron diet or intramuscular injections of iron dextran, and in situhybridization analyses on liver samples were performed. Results: These iron treatments determined parenchymal or reticuloendothelial cell iron overload, respectively.

Brijesh C. Sharma, Rakesh Aggarwal, Subhash R. Naik – 1 April 1995

Marshall J. Orloff, Richard H. Bell, Mark S. Orloff, A. Gerson Greenburg, William G. M. Hardison, J. Michael Henderson, Norman D. Grace – 1 April 1995

Olle Reichard, Hans Glaumann, Aril Frydén, Gunnar Norkrans, Robert Schvarcz, Anders Sönnerborg, Zhi‐Bing Yun, Ola Weiland – 1 April 1995 – Fourteen patients with chronic hepatitis C who had a sustained response to a 60‐week interferon alfa‐2b treatment course were followed, biochemically and virologically, 2 years after treatment cessation. Biopsies were repeated in 12 of 14 for histological and virological evaluation at 2‐year follow‐up.

Yolanta T. Kruszynska, Mohammad A. Ghatei, Stephen R. Bloom, Neil McIntyre – 1 April 1995 – A blunted initial insulin secretory response may contribute to oral glucose intolerance in cirrhosis. Oral glucose is a better stimulant to insulin secretion than intravenous (IV) glucose in part because of release of gut peptides, notably glucose‐dependent insulinotropic peptide (GIP) and glucagon‐like peptide 1 [7‐36 amide] (GLP‐1 [7‐36 amide]).

Malcolm Mackinnon, Cindy Clayton, John Plummer, Michael Ahern, Patricia Cmielewski, Anthony Ilsley, Pauline Hall – 1 April 1995 – The role of iron deposition in initiating hepatic fibrosis in iron overload disorders is not clearly established, and it is becoming increasingly recognized that iron may be interacting with other potential liver‐damaging agents. The authors therefore examined the interplay of iron and alcohol in rats administered subtoxic doses of carbon tetrachloride (CCl4) vapor at 20 ppm in customized chambers.

Nobuhiro Tsukada, Cameron A. Ackerley, M. James Phillips – 1 April 1995 – The distribution of actin filaments and actin‐binding proteins in the bile canaliculus (BC) of normal human hepatocytes was determined as a means of establishing the structure and organization of the BC cytoskeleton. Immunoblots demonstrated that actin, and the actin‐binding proteins, myosin II, tropomyosin, vinculin, α‐actinin, villin, were present, as were the non‐actin‐related proteins β‐tubulin, and cytokeratins.

Niclas Pantzar, Peter B. F. Bergqvist, Mogens Bugge, Gunnar Olaison, Stefan Lundin, Bengt Jeppsson, Björn Weström, Finn Bengtsson – 1 April 1995 – Functional changes of the intestinal barrier that may occur after the creation of a portacaval shunt (PCS) were investigated. After chronic PCS in the rat, the intestinal absorption of and the jejunal permeability to the inert polymer marker polyethylene glycol (PEG) with molecular weight (Mw) ranging from 400 to 1,000 g/mol were investigated.