Scott L. Friedman – 1 April 1995 – Background/Aims: Liver fibrosis and cirrhosis represent common pathological findings in humans with iron overload. This study was undertaken to assess whether in vivo targeting of iron to liver parenchymal or nonparenchymal cells would differently affect collagen gene activity. Methods: Rats were treated with an iron diet or intramuscular injections of iron dextran, and in situhybridization analyses on liver samples were performed. Results: These iron treatments determined parenchymal or reticuloendothelial cell iron overload, respectively.

Donna L. Waters, Stuart F. A. Dorney, Margie A. Gruca, Hugh C. O. Martin, Robert Howman‐Giles, Alex E. Kan, Merl de Silva, Kevin J. Gaskin – 1 April 1995 – Focal and multilobular biliary cirrhosis are considered pathognomonic of cystic fibrosis (CF) and almost invariably have been reported in patients with steatorrhea. In contrast, patients with pancreatic sufficiency and normal absorption are considered less likely to develop liver or biliary tract problems.

Tania Roskams, Han Moshage, Rita de Vos, David Guido, Paul Yap, Valeer Desmet – 1 April 1995 – Because increasing evidence implicates heparan sulfate proteoglycans (HSPGs) as essential cofactors in receptor‐growth factor interactions, in cell‐cell recognition systems, and in cell‐matrix adhesion processes and yet little is known about their cellular distribution pattern and cellular sources in liver tissue, we used monoclonal antibodies specific for the core proteins of syndecan1, 2, 3, 4, glypican, and perlecan to investigate their immunohistochemical expression in normal adult human liver

Lorenzo Polimeno, Alessandro Azzarone, Qui Hua Zeng, Carmine Panella, Vladimir Subbotin, Brian Carr, Boumediene Bouzahzah, Antonio Francavilla, Thomas E. Starzl – 1 April 1995 – The proliferative response of the rat liver was measured after temporary or permanent total biliary obstruction (BDO) and in different regions after selective ligation of the lobar ducts draining the right 60% of the hepatic mass. The results were compared with those after 70% partial hepatectomy (PH).

Renee C. Lin, Barbara A. Miller, Timothy J. Kelly – 1 April 1995 – Previous studies have shown that plasma levels of high‐density lipoprotein (HDL) cholesterol and the two major protein components of HDLs, i.e., apolipoproteins AI and AII, were elevated in male alcoholic patients without serious liver injury. By contrast, alcohol effect on apolipoprotein E remains unclear. Apolipoprotein E is a major component of very low—density lipoprotein (VLDL) and a minor component of human high‐density lipoprotein.

1 April 1995

George A. Ellsworthm – 1 April 1995

René Romero, Joel E. Lavine – 1 April 1995 – Background: Hereditary tyrosinemia type I is an autosomal recessive inborn error of metabolism caused by a deficiency of the enzyme fumarylacetoacetate hydrolase. The disorder clusters in the Saguenay‐Lac‐St.‐Jean area of Quebec. In this region, 1 of 1846 newborns is affected and 1 of every 22 persons is thought to be a carrier. Recently, we identified a splice mutation and two nonsense mutations in the fumarylacetoacetate hydrolase gene in two patients from Quebec with tyrosinemia type I.

Karen E. Iles, Laura E. Nagy – 1 April 1995 – The liver is a primary target for both acute and chronic effects of ethanol. Because ethanol is known to alter the function of guanine nucleotide regulatory proteins (G‐proteins), changes in hepatic G‐proteins could contribute to the adverse effects of ethanol on liver function. Male Wistar rats were fed a liquid diet containing 36% of calories as ethanol for 4 weeks. Control rats were pair‐fed or allowed free access to a diet that isocalorically substituted maltose dextrins for ethanol.

Debra L. Laskin, Carol R. Gardner, Veronica F. Price, David J. Jollow – 1 April 1995 – Acetaminophen is a mild analgesic and antipyretic agent that is safe and effective when taken in therapeutic doses. Ingestion of overdoses, however, may lead to acute liver failure accompanied by centrilobular degeneration and necrosis.