Osamu Nakashima, Shigetaka Sugihara, Masayoshi Kage, Masamici Kojiro – 1 July 1995 – Some surgically resected small hepatocellular carcinoma (HCC) up to 2 cm in diameter have indistinct margins, and it is sometimes difficult to identify the margins of the cancer nodule in the resected specimen. We classified such tumors as small HCC with indistinct margins and carried out a morphological study to define their characteristics in comparison with small HCC with distinct margins as a control group. We have encountered 27 examples among 86 tumors smaller than 2.0 cm in diameter.

Shiv K. Sarin, Vir S. Negi, Richa Dewan, Smailaja Sasan, Anoop Saraya – 1 July 1995 – Limited information is available on the prevalence of gallstones in the first‐degree relatives of gallstone patients. Three groups of subjects were studied by realtime ultrasound examination: group A, 105 index gallstone patients (male/female; 20:85); group B, 330 first‐degree relatives of index patients; group C, matched controls for group A (n = 105) and group B (n = 330) subjects. Dietary, anthropometric, and biochemical investigations were carried out.

Amy J. Weiner – 1 July 1995 – The hypervariable region 1 (HVR1) of the putative second envelope glycoprotein (gp70) of hepatitis C virus (HCV) contains a sequence‐specific immunological B‐cell epitope that induces the production of antibodies restricted to the specific viral isolate, and anti‐HVR1 antibodies are involved in the genetic drift of HVR1 driven by immunoselection (N. Kato, H. Sekiya, Y. Ootsuyama, T. Nakazawa, M. Hijikata, S. Ohkoshi, and K. Shimotohno, J. Virol. 67:3923–3930, 1993).

Raymond S. Koff – 1 July 1995

Raymond S. Koff – 1 July 1995

Byers W. Shaw – 1 July 1995

Roger L. Jenkins – 1 July 1995

Kazuhiko Koizumi, Nobuyuki Enomoto, Masayuki Kurosaki, Takeshi Murakami, Namiki Izumi, Fumiaki Marumo, Chifumi Sato – 1 July 1995 – Hepatitis C virus (HCV) populations in vivo exist as a mixture of heterogeneous viruses called quasispecies, which have variations in the hypervariable region (HVR). However, the relationship between the diversity of HVR quasispecies, the disease stage, or the interferon (IFN) responsiveness remains to be elucidated.

Kenji Takenaka, Kazuharu Yamamoto, Akinobu Taketomi, Hidetoshi Itasaka, Eisuke Adachi, Ken Shirabe, Takashi Nishizaki, Katsuhiko Yanaga, Keizo Sugimachi – 1 July 1995 – To assess the differences in the surgical results between patients with hepatitis B‐ and hepatitis C‐related hepatocellular carcinoma (HCC), the operative outcomes of 30 patients with hepatitis B surface antigen (HBsAg)‐positive (the B‐HCC group) and 96 patients with hepatitis C antibody (HCVAb)‐positive (the C‐HCC group), who had undergone hepatic resection from 1989 to 1993, were compared.

Hau‐Tim Chung, Ching‐Lung Lai, Anna S. F. Lok – 1 July 1995 – This study was conducted to determine the rate of detection of serum hepatitis B virus (HBV) DNA in hepatitis B surface antigen (HBsAg)‐negative decompensated cirrhotic patients who had hepatitis B core and/or surface antibodies (anti‐HBc and/or anti‐HBs), and to compare the outcome of HBsAg‐positive cirrhotic patients who did or did not clear HBsAg during follow‐up. Six (5%) of 121 HBsAg‐positive cirrhotic patients lost HBsAg after 0.2 to 17.1 years (mean, 9.1 ± 6.2 yr) of follow‐up.