Expanding the immunosuppresive repertoire

Nancy L. Ascher – 1 July 1996 – In a 6 month open label, randomized, multi‐center trial, we compared the efficacy and safety of mycophenolate mofetil (MMF) with high dose intravenous steroids (IVS) for the treatment of refractory, acute cellular rejection in recipients of first or second cadaveric or living‐donor renal allografts. A total of 150 patients were enrolled and randomized in a 1‐to‐1 ratio to receive oral MMF 1.5 g twice daily (n = 77) or i.v.

Wound recurrence after resection of hepatocellular carcinoma

Eric Koffi, Vincent Moutardier, Alain Sauvanet, Roger Noun, Jean François Fléjou, Jacques Belghiti – 1 July 1996 – Cutaneous metastases arising along the exit site of an abdominal drain in one patient and within the operative wound in two others after resection of a hepatocellular carcinoma (HCC) are reported. All patients underwent curative hepatic resection, and cutaneous metastases occurred 9, 12, and 22 months after surgery respectively. Cutaneous metastases were not associated with intrahepatic recurrence and were treated by local excision.

Alterations in glutathione homeostasis in mutant Eisai hyperbilirubinemic rats

S C Lu, J Cai, J Kuhlenkamp, W Sun, H Takikawa, O Takenaka, T Horie, J Yi, N Kaplowitz – 1 July 1996 – Eisai hyperbilirubinemic rats (EHBR) are mutant Sprague‐Dawley rats that exhibit impaired biliary organic anion and reduced glutathione (GSH) secretion. In addition, liver GSH levels are twice that of age‐ matched controls. The mechanisms for the defect in biliary GSH secretion and the increase in cell GSH are not fully understood. We previously showed that canalicular membrane‐enriched vesicles isolated from EHBR livers exhibited normal GSH transport.

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