Hirokazu Yokoyama, Shigeyuki Nagata, Susumu Moriya, Shinzo Kato, Takashi Ito, Kiyotaka Kamegaya, Hiromasa Ishii – 1 May 1995 – Experimental hepatic fibrosis was produced in the guinea pig. We produced hepatic necrosis associated with inflammatory cell infiltration in guinea pigs immunized with acetaldehyde adducts and fed ethanol for 40 days. Extending the period of these treatments to 90 days resulted in producing hepatic fibrosis developing around individual hepatocytes in the terminal hepatic venule areas and portal areas, accompanied by an increase in hepatic hydroxyproline content.

Gianluigi Vendemiale, Ferruccio Guerrieri, Ignazio Grattagliano, Domenico Didonna, Leonilde Muolo, Emanuele Altomare – 1 May 1995 – The rate of mitochondrial oxidative phosphorylation and the cytosolic and mitochondrial total and oxidized glutathione concentrations were studied in regenerating rat livers after partial (70%) hepatectomy. The rate of mitochondrial oxidative phosphorylation progressively decreased during the early prereplicative phase of liver regeneration. This was accompanied by a progressive decrease in mitochondrial, but not cytosolic, glutathione concentration.

Bettina Grasl Kraupp, Branislav Ruttkay‐Nedecky, Helga Koudelka, Krystyna Bukowska, Wilfried Bursch, Rolf Schulte‐Hermann – 1 May 1995 – Detection of DNA fragments in situ using the terminal deoxyribonucleotidyl transferase (TDT)‐mediated dUTP‐digoxigenin nick end labeling (TUNEL) assay is increasingly applied to investigate active cell death (apoptosis). We studied the specificity of the assay in well‐defined models of apoptosis and necrosis as well as in postmortem autolysis in rat liver.

Roger W. Chapman – 1 May 1995 – Background/Aims: Perinuclear antineutrophil cytoplasmic antibodies (pANCA) were found at high frequency in patients with primary sclerosing cholangitis and ulcerative colitis. In this study, to accumulate further evidence for the importance of genetic factors in pathogenesis of inflammatory bowel disease, sera of patients with inflammatory bowel disease and primary sclerosing cholangitis and their unaffected family members were tested for pANCA.

Raymond S. Koff – 1 May 1995

Byers W. Shaw – 1 May 1995

Shu Nakano, Joji Haratake, Hiroshi Hashimoto – 1 May 1995 – The chronological changes in ductular epithelium and peribiliary capillary plexuses (PBPs) after bile duct ligation are not well understood. Therefore, we examined alterations in both intrahepatic bile ductules and peribiliary microcirculation in rats after ligation of the common bile duct using immunohistochemistry, transmission electron microscopes (TEM), and scanning electron microscopes (SEM).

Raymond S. Koff – 1 May 1995

Makoto Haramaki, Hirohisa Yano, Kazunori Fukuda, Seiya Momosaki, Sachiko Ogasawara, Masamichi Kojiro – 1 May 1995 – CD44 is a glycosylated cell surface adhesion molecule expressed on a diverse range of cells and has several variant forms, some of which are involved in metastasis of cancer cells.

Rafael Mañez, Robert H. Kelly, Makoto Kobayashi, Shunichi Takaya, Oscar Bronsther, David Kramer, Rene J. Duquesnoy, Yuichi Iwaki, John J. Fung, Thomas E. Starzl, Anthony J.