P. Aiden McCormick, Jason Chin, Lynda Greenslade, Stelios Karatapanis, Robert Dick, Neil McIntyre, Andrew K. Burroughs – 1 May 1995 – Octreotide is thought to reduce splanchnic and variceal blood flow with minimal effects on the systemic circulation in cirrhotic patients with portal hypertension. However, we noticed significant bradycardia in some patients immediately after administration of bolus doses of octreotide. Therefore, we investigated the effect of intravenous octreotide on systemic hemodynamics in 59 patients with cirrhosis.

Staffan Sahlin, Dagny Ståhlberg, Kurt Einarsson – 1 May 1995 – The objective of this study was to investigate possible pathogenetic factors for cholesterolosis. Liver tissue, gallbladder mucosa, and gallbladder bile were collected in patients with cholesterol gallstones (GS) (14 patients with and 14 patients without cholesterolosis) and gallstone‐free (GSF) subjects (11 with and 21 without cholesterolosis) undergoing cholecystectomy. In cholesterolosis, the gallbladder mucosa was characterized by a fivefold increase in esterified cholesterol and normal content of free cholesterol.

Jürgen Tudyka, Wolfgang Kratzer, Klaus Kuhn, Paul Janowitz, Johannes Georg Wechsler, Guido Adler – 1 May 1995 – Bile sampling without the risk of contamination by pancreatic and duodenal secretions and avoiding unpredictable influences of general anesthesia during biliary surgery on biliary analytics are feasible with percutaneous puncture of the gallbladder. In 207 patients with gallstones, gallbladder puncture was performed under local anesthesia with a 22‐gauge spinal needle under continuous real‐time ultrasound guidance.

1 May 1995

Ian R. Wanless, Julia J. Liu, Jagdish Butany – 1 May 1995 – The pathogenesis of congestive cirrhosis is generally thought to be a reaction of the hepatic stroma to hypoxia, pressure, or necrosis. This does not explain the poor correlation between symptoms and severity of fibrosis and the irregular distribution of fibrosis within the liver. We have observed healed hepatic vein (HV) thrombosis in patients with congestive heart failure (CHF).

Ian R. Wanless, Florence Wong, Lawrence M. Blendis, Paul Greig, E. Jenny Heathcote, Gary Levy – 1 May 1995 – Obliterative lesions in portal veins (PVs) and hepatic veins (HVs) of all sizes are known to occur in cirrhotic livers. PV lesions have generally been attributed to thrombosis, but the pathogenesis of the HV (veno‐occlusive) lesions is unknown. We have studied 61 cirrhotic livers removed at transplantation to clarify the prevalence, distribution, and pathogenesis of venous lesions, as well as the association of these lesions with other morphological features and clinical morbidity.

Junichi Shoda, Bing‐Fang He, Naomi Tanaka, Yasushi Matsuzaki, Toshiaki Osuga, Shunji Yamamori, Hiroshi Miyazaki, Jan Sjövall – 1 May 1995 – A total of 100 nonobese and normolipidemic subjects (29 control subjects, 49 patients with cholesterol stones [CSs], and 22 patients with brown pigment stones) were studied to elucidate the pathogenetic contributions of deoxycholate (DC) to supersaturated bile formation with special reference to de novo syntheses of cholesterol and bile acids in the liver.

Neil A. Grossman – 1 May 1995

1 May 1995

Yuhki Hamada, Ari Karjalainen, Fyfe L. Bygravec – 1 May 1995 – The actions of vasopressin and glucagon, administered alone or together, were assessed on bile flow in perfused livers from rats made cholestatic by the injection of ethynylestradiol and from those allowed to recover from such treatment. Concomitant measurements were made of biliary calcium output as well as changes in the perfusate Ca2+ concentration, glucose output, and oxygen uptake. Experiments were also conducted where cholestasis was induced in vitro in the perfused liver by the infusion of phalloidin.