Hematopoietic stem cell markers are expressed by ductal plate and bile duct cells in developing human liver

Karin Blakolmer, Kasimirsz Jaskiewicz, Harold A. Dunsford, Simon C. Robson – 1 June 1995 – The identification of ductal plate cells as likely progenitors for bile duct epithelium and hepatocytes and their possible reappearance as oval cells in the regenerating liver have generated much interest in their pluri‐potential capacities. We have examined the distribution of three hematopoietic stem cell markers, c‐kit, CD34, and CD33 in addition to laminin, the standard cytokera‐tin markers CAM 5.2, CK 18, and CK 7 and the oval cell marker OV‐6 in fetal liver during various stages of development.

Low prevalence of hepatitis C virus infection in porphyria cutanea tarda in germany

Ulrich Stölzel, Erich Köstler, Christiane Koszka, Maricka Stöffler‐Meilicke, Detlef Schuppan, Rajan Somasundaram, Manfred O. Doss, Karl O. Habermehl, Ernst O. Riecken – 1 June 1995 – Previous studies from Spain, Italy, and France have demonstrated a high prevalence (71% to 91%) of antibodies against hepatitis C virus in patients with porphyria cutanea tarda (PCT). To determine the role of hepatitis C virus (HCV) in PCT in Germany, we have assessed the prevalence of antibodies against HCV and hepatitis B virus (HBV) in 106 patients (mean age, 60 ± 14 years) with the disease.

Comparison of endoscopic variceal injection sclerotherapy and ligation for the treatment of esophageal variceal hemorrhage: A prospective randomized trial

Ming‐Chih Hou, Han‐Chieh Lin, Benjamin Ing‐Tiau Kuo, Chen‐Hsiang Chen, Fa‐Yauh Lee, Shou‐Dong Lee – 1 June 1995 – To determine the efficacy of endoscopic variceal sclerotherapy (EVS) and ligation (EVL) in the management of esophageal variceal bleeding, 134 cirrhotic patients were randomized to receive either treatment. The clinical and endoscopic characteristics were similar in both groups. Active bleeding was controlled with ligation (20 of 20) as efficiently as with sclerotherapy (14 of 16).

Further characterization and comparison of inducible nitric oxide synthase in mouse, rat, and human hepatocytes

Andreas K. Nussler, Mauricio Di Silvio, Zhi‐Ze Liu, David A. Geller, Paul Freeswick, Kenneth Dorko, Fabio Bartoli, Timothy R. Billiar – 1 June 1995 – Marked differences in induced nitric oxide (NO) synthesis occur between species. We have previously shown that both human and rat hepatocytes express an inducible NO synthase in response to cytokines and lipopolysaccharide. In this study, we compare the expression and regulation of cytokine‐induced NO synthase in hepatocytes isolated from three species, human, rat, and mouse.

Participation of small intraportal stem cells in the restitutive response of the liver to periportal necrosis induced by allyl alcohol

Leonid Yavorkovsky, Eva Lai, Zoran Ilic, Stewart Sell – 1 June 1995 – To determine the involvement of different hepatocyte populations in response to periportal injury, the restitutive response to allyl alcohol (AA) injury was examined.

DNA damage and donor livers: Disease unbidden?

Kathleen Schwarz – 1 June 1995 – Endogenous DNA adducts may contribute to the etiology of human genetic disease and cancer. One potential source of endogenous DNA adducts is lipid peroxidation, which generates mutagenic carbonyl compounds such as malondialdehyde. A sensitive mass spectrometric method permitted detection and quantitation of the major malondialdehyde‐DNA adduct, a pyrimidopurinone derived from deoxyguanosine. DNA from disease‐free human liver was found to contain 5400 adducts per cell, a frequency comparable to that of adducts formed by exogenous carcinogens.

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