1 June 1995

Karin Blakolmer, Kasimirsz Jaskiewicz, Harold A. Dunsford, Simon C. Robson – 1 June 1995 – The identification of ductal plate cells as likely progenitors for bile duct epithelium and hepatocytes and their possible reappearance as oval cells in the regenerating liver have generated much interest in their pluri‐potential capacities. We have examined the distribution of three hematopoietic stem cell markers, c‐kit, CD34, and CD33 in addition to laminin, the standard cytokera‐tin markers CAM 5.2, CK 18, and CK 7 and the oval cell marker OV‐6 in fetal liver during various stages of development.

Ulrich Stölzel, Erich Köstler, Christiane Koszka, Maricka Stöffler‐Meilicke, Detlef Schuppan, Rajan Somasundaram, Manfred O. Doss, Karl O. Habermehl, Ernst O. Riecken – 1 June 1995 – Previous studies from Spain, Italy, and France have demonstrated a high prevalence (71% to 91%) of antibodies against hepatitis C virus in patients with porphyria cutanea tarda (PCT). To determine the role of hepatitis C virus (HCV) in PCT in Germany, we have assessed the prevalence of antibodies against HCV and hepatitis B virus (HBV) in 106 patients (mean age, 60 ± 14 years) with the disease.

Ming‐Chih Hou, Han‐Chieh Lin, Benjamin Ing‐Tiau Kuo, Chen‐Hsiang Chen, Fa‐Yauh Lee, Shou‐Dong Lee – 1 June 1995 – To determine the efficacy of endoscopic variceal sclerotherapy (EVS) and ligation (EVL) in the management of esophageal variceal bleeding, 134 cirrhotic patients were randomized to receive either treatment. The clinical and endoscopic characteristics were similar in both groups. Active bleeding was controlled with ligation (20 of 20) as efficiently as with sclerotherapy (14 of 16).

Andreas K. Nussler, Mauricio Di Silvio, Zhi‐Ze Liu, David A. Geller, Paul Freeswick, Kenneth Dorko, Fabio Bartoli, Timothy R. Billiar – 1 June 1995 – Marked differences in induced nitric oxide (NO) synthesis occur between species. We have previously shown that both human and rat hepatocytes express an inducible NO synthase in response to cytokines and lipopolysaccharide. In this study, we compare the expression and regulation of cytokine‐induced NO synthase in hepatocytes isolated from three species, human, rat, and mouse.

Leonid Yavorkovsky, Eva Lai, Zoran Ilic, Stewart Sell – 1 June 1995 – To determine the involvement of different hepatocyte populations in response to periportal injury, the restitutive response to allyl alcohol (AA) injury was examined.

Tushar Patel, Gregory J. Gores – 1 June 1995

Kathleen Schwarz – 1 June 1995 – Endogenous DNA adducts may contribute to the etiology of human genetic disease and cancer. One potential source of endogenous DNA adducts is lipid peroxidation, which generates mutagenic carbonyl compounds such as malondialdehyde. A sensitive mass spectrometric method permitted detection and quantitation of the major malondialdehyde‐DNA adduct, a pyrimidopurinone derived from deoxyguanosine. DNA from disease‐free human liver was found to contain 5400 adducts per cell, a frequency comparable to that of adducts formed by exogenous carcinogens.

1 June 1995

Masahiko Morita, Yoshifumi Watanabe, Toshihiro Akaike – 1 June 1995 – We examined the interactive effect of several cytokines (interleukin‐1 beta [IL‐1β], tumor necrosis factor alpha [TNF‐α], interferon gamma [IFN‐γ], IL‐6, IFN‐α/B, and hepatocyte growth factor [HGF]) presumably involved in hepatitis, on primary cultured murine hepatocytes. Among these cytokines, only IFN‐γ induced LDH release from hepatocytes in both time‐ and dose‐dependent fashions. The cytotoxic effect was inhibited by antiserum—containing anti‐mouse IFN‐γ monoclonal antibodies (R4‐6A2).