Effect of selective bowel decontamination with norfloxacin on spontaneous bacterial peritonitis, translocation, and survival in an animal model of cirrhosis

Bruce A. Runyon, Mauro Borzio, Sharon Young, Susan U. Squier, Carlos Guarner, Michelle A. Runyon – 1 June 1995 – Selective bowel decontamination with the orally administered quinolone antibiotic, norfloxacin, has been shown to suppress gut gram‐negative bacteria and help prevent gram‐negative infections in cirrhotic patients who are at high risk of bacterial infection. Because this drug does not eradicate gram‐positive organisms, it is conceivable that gram‐positives could replace the suppressed gram‐negatives in the gut and lead to subsequent infection.

Molecular mechanism of hepatocellular injury in alpha1 antitrypsin deficiency

Frederick K. Askari – 1 June 1995 – Liver injury in PiZZ α1‐antitrypsin (α1‐AT) deficiency probably results from toxic effects of the abnormal α1‐AT molecule accumulating within the ER of liver cells. However, only 12–15% of individuals with this same genotype develops liver disease. Therefore, we predicted that other genetic traits that determine the net intracellular accumulation of the mutant α1‐AT molecule would also determine susceptibility to liver disease.

Effects of acetaldehyde on nuclear protein binding to the nuclear factor I consensus sequence in the α2(I) collagen promoter

Frank A. Anania, James J. Potter, Lynda Rennie‐Tankersley, Esteban Mezey – 1 June 1995 – Acetaldehyde has been shown to increase collagen production in cultured rat myofibroblastlike cells and to activate the mouse α2(I) collagen promoter in transfected NIH 3T3 cells. Nuclear factor I (NF‐I), a CCAAT binding transcription factor, is known to bind and activate the α(I) and α2(I) collagen genes. Activation of the α2(I) collagen promoter was not observed when the NF‐I binding site of the promoter was deleted.

Nonalcoholic steatohepatitis: Tightening the morphological screws on a hepatic rambler

Randall G. Lee – 1 June 1995 – Background/Aims: In the past, nonalcoholic steatohepatitis has been described mostly in obese women with diabetes. The aim of this study was to describe a series of patients with nonalcoholic steatohepatitis with a different clinical profile. Methods: The clinical, biochemical, and histological features of 33 patients with nonalcoholic steatohepatitis seen from July 1990 to June 1993 were analyzed. Results: The mean age was 47 years. All patients were antibody to hepatitis C virus‐negative.

Immediate early detection of urokinase receptor after partial hepatectomy and its implications for initiation of liver regeneration

Wendy M. Mars, Meng‐Lun Liu, Richard P. Kitson, Ronald H. Goldfarb, Megan K. Gabauer, George K. Michalopoulos – 1 June 1995 – Hepatocyte growth factor (HGF), also known as scatter factor, is believed to play a primary role in liver regeneration. HGF is produced in an inactive single‐chain form that can be cleaved in vitro to the active two‐chain form by tissue‐type and urokinase‐type plasminogen (PLG) activators (tPA and uPA).

Subscribe to