Pulmonary hypertension after transjugular intrahepatic portosystemic shunt: Effects on right ventricular function

P Van der Linden, O Le Moine, M Ghysels, M Ortinez, J Deviere – 1 May 1996 – The short‐ and mid‐term hemodynamic effects of transjugular intrahepatic portosystemic shunt (TIPS) were studied in 16 sedated cirrhotic patients. Indications included relapsing variceal bleeding (n = 10) and refractory ascites (n = 6).

Failed allografts and causes of death after orthotopic liver transplantation from 1985 to 1995: Decreasing prevalence of irreversible hepatic allograft rejection

Jurgen Ludwig, Etsuko Hashimoto, Michael K. Porayko, Terry M. Therneau – 1 May 1996 – Mayo Clinic pathology files from March 1985 to March 1995 contained records of 584 orthotopic liver transplantations in 515 patients. The most common indication for liver transplantation was primary sclerosing cholangitis (PSC), followed by primary biliary cirrhosis (PBC), and cryptogenic cirrhosis. In 59 patients, a total of 69 single or repeated retransplantations became necessary.

Sanctuary of hepatitis B virus in bone‐marrow cells of patients undergoing liver transplantation

Yaron Ilan, Eitan Galuns, Arnon Nagler, Yaakov Baruch, Nelli Livni, Ran Tur‐Kaspa – 1 May 1996 – Hepatitis B virus (HBV) reinfection after liver transplantation is a major problem. HBV is mainly a hepatotrophic virus but replicates in many extrahepatic tissues. We present here two cases of infected patients who underwent liver transplantation. Both underwent bone marrow (BM) and liver biopsies after transplantation. Biopsy specimens were stained for hepatitis B surface antigen (HBsAg), and bone marrow aspirates and were separated for all subsets of cells.

Vasoactive intestinal peptide in cirrhotic rats: Hemodynamic effects and mesenteric arterial receptor characteristics

S S Lee, M Huang, Z Ma, O Rorstad – 1 May 1996 – Vasoactive intestinal peptide (VIP) blood levels in cirrhosis are elevated, but its hemodynamic and receptor characteristics remain unclarified. We aimed to quantify VIP receptor characteristics in mesenteric arteries, plasma VIP concentration by radioimmunoassay (RIA), and the hemodynamic effects of VIP infusion in bile duct‐ligated (BDL) cirrhotic and sham‐operated control rats. Mesenteric arterial membranes were prepared by ultracentrifugation, and receptor characteristics were studied using 125I‐labeled VIP as a radioligand.

Long‐term octreotide treatment prevents vascular hyporeactivity in portal‐hypertensive rats

C C Sieber, F Lee, R J Groszmann – 1 May 1996 – Chronically portal‐hypertensive rats show in vitro vascular hyporeactivity in large part mediated by the endothelium‐derived vasodilator nitric oxide. We tested whether long‐term octreotide treatment (15 micrograms/kg subcutaneously in 5% D/W, 8‐hourly) corrects the in vitro vascular hyporeactivity.

Prediction of risk of liver disease by alcohol intake, sex, and age: A prospective population study

U Becker, A Deis, T I Sorensen, M Gronbaek, K Borch‐Johnsen, C F Muller, P Schnohr, G Jensen – 1 May 1996 – The association between self‐reported alcohol intake and the risk of future liver disease was studied in a large population‐based prospective cohort with 12‐year follow‐up. Alcohol intake was assessed in 13,285 men and women aged 30 to 79 years by a self‐administered questionnaire.

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