Interaction of human gallbladder mucin with calcium hydroxyapatite: Binding studies and the effect on hydroxyapatite formation

Sui‐Min Qiu, Gary Wen, Julie Wen, Roger D. Soloway, Roger S. Crowther – 1 June 1995 – Calcium hydroxyapatite (HAP) crystals formed in vitro in the presence of polymeric human gallbladder mucin (1.0 mg/mL) were smaller (0.75 ± 0.39 μm) than control crystals (7.86 ± 2.76 μm), but the mucin did not affect the kinetics of crystal formation or alter the amount of mineral phase present at equilibrium. In contrast, glycopeptide subunits produced by proteolysis of the native mucin had no effect on HAP crystal size.

Overexpression of c‐met protooncogene product and raised Ki67 index in hepatocellular carcinomas with respect to benign liver conditions

Walter F. Grigioni, Michelangelo Fiorentino, Antonia d'Errico, Antonio Ponzetto, Tiziana Crepaldi, Maria Prat, Paolo M. Comoglio – 1 June 1995 – The c‐met protooncogene encodes a 190‐kd transmembrane tyrosine kinase. This molecule is the receptor for the hepatocyte growth factor (HGF), which is an important mitogen for hepatocytes both in vitro and in vivo. In experimental models, the c‐met transcripts appeared strongly expressed by actively proliferating oval cells (OCs).

Increased aortic cyclic guanosine monophosphate concentration in experimental cirrhosis in rats: Evidence for a role of nitric oxide in the pathogenesis of arterial vasodilation in cirrhosis

Michel Niederberger, Pere Ginès, Phoebe Tsai, Pierre‐Yves Martin, Kenneth Morris, André Weigert, Ivan McMurtry, Robert W. Schrier – 1 June 1995 – Arterial vasodilation is considered to be the key factor in the development of sodium and water retention leading to ascites formation in cirrhosis. To determine if nitric oxide (NO) is involved in the pathogenesis of arterial vasodilation in cirrhosis, we measured the concentration of cyclic guanosine monophosphate (cGMP), the second messenger of NO, in arterial tissue from rats with carbon tetrachloride—induced cirrhosis.

Spectrum of liver disease and duck hepatitis B virus infection in a large series of chinese ducks with hepatocellular carcinoma

Agnes Duflot, Raj Mehrotra, Shun‐Zhang Yu, Luc Barraud, Christian Trepo, Lucyna Cova – 1 June 1995 – The striking difference in the geographical distribution of liver cancer in ducks raised the question of whether duck hepatitis B virus (DHBV), like mammalian hepadnaviruses, could be an oncogenic agent. Hepatocellular carcinomas (HCCs) have been found only in domestic ducks in Qidong, China, where hepatitis B virus infection and aflatoxin B1 (AFB1) are both risk factors and where a high frequency of human HCCs has been reported.

Hypocalcemia decreases the early and late responses to epidermal growth factor in rat hepatocytes

Marc Bilodeau, Sébastien J. Provencher, Stéphane Néron, Pierre Haddad, Sylvie Vallières, Marielle Gascon‐Barré – 1 June 1995 – Extreme variations in extracellular Ca2+ concentrations ([Ca2+]e) modify the signaling generated by many hormones and growth factors. However, the influence of physiological changes in [Ca2+]e on the response to hepatic mitogens remains largely unknown.

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