Han Roelofsen, Conny T. M. Bakker, Berry Schoemaker, Marc Heijn, Peter L. M. Jansen, Ronald P. J. Oude Elferink – 1 June 1995 – The hepatocanalicular transport of a large number of organic anions, such as bilirubin glucuronides and glutathione conjugates in the rat, is mediated by an adenosine triphosphate (ATP)‐dependent transport system, which is termed canalicular multispecific organic anion transporter (cMOAT). This system is mainly defined by its deficiency in mutant TR− rats.

Dianzhong Luo, Karin Vanderkerken, Luc Bouwens, Peter J. K. Kuppen, Evelyne Crabbé, Eddie Wisse – 1 June 1995 – Pit cells are a unique population of cells in sinusoids and peripheral blood, which can be considered natural killer (NK) cells with large granular lymphocyte (LGL) morphology. The aim of this study was to investigate the use of the monoclonal antibody (MAb) 3.2.3 as a specific marker of rat pit cells to detect their number and distribution in the liver.

Bruce A. Runyon, Mauro Borzio, Sharon Young, Susan U. Squier, Carlos Guarner, Michelle A. Runyon – 1 June 1995 – Selective bowel decontamination with the orally administered quinolone antibiotic, norfloxacin, has been shown to suppress gut gram‐negative bacteria and help prevent gram‐negative infections in cirrhotic patients who are at high risk of bacterial infection. Because this drug does not eradicate gram‐positive organisms, it is conceivable that gram‐positives could replace the suppressed gram‐negatives in the gut and lead to subsequent infection.

Frederick K. Askari – 1 June 1995 – Liver injury in PiZZ α1‐antitrypsin (α1‐AT) deficiency probably results from toxic effects of the abnormal α1‐AT molecule accumulating within the ER of liver cells. However, only 12–15% of individuals with this same genotype develops liver disease. Therefore, we predicted that other genetic traits that determine the net intracellular accumulation of the mutant α1‐AT molecule would also determine susceptibility to liver disease.

Frank A. Anania, James J. Potter, Lynda Rennie‐Tankersley, Esteban Mezey – 1 June 1995 – Acetaldehyde has been shown to increase collagen production in cultured rat myofibroblastlike cells and to activate the mouse α2(I) collagen promoter in transfected NIH 3T3 cells. Nuclear factor I (NF‐I), a CCAAT binding transcription factor, is known to bind and activate the α(I) and α2(I) collagen genes. Activation of the α2(I) collagen promoter was not observed when the NF‐I binding site of the promoter was deleted.

Randall G. Lee – 1 June 1995 – Background/Aims: In the past, nonalcoholic steatohepatitis has been described mostly in obese women with diabetes. The aim of this study was to describe a series of patients with nonalcoholic steatohepatitis with a different clinical profile. Methods: The clinical, biochemical, and histological features of 33 patients with nonalcoholic steatohepatitis seen from July 1990 to June 1993 were analyzed. Results: The mean age was 47 years. All patients were antibody to hepatitis C virus‐negative.

Clifford A. Brass, Arnold Kooij, Wilma M. Frederiks, Cornelis J. F. Van Noorden – 1 June 1995

Wendy M. Mars, Meng‐Lun Liu, Richard P. Kitson, Ronald H. Goldfarb, Megan K. Gabauer, George K. Michalopoulos – 1 June 1995 – Hepatocyte growth factor (HGF), also known as scatter factor, is believed to play a primary role in liver regeneration. HGF is produced in an inactive single‐chain form that can be cleaved in vitro to the active two‐chain form by tissue‐type and urokinase‐type plasminogen (PLG) activators (tPA and uPA).

Josef E. Fischer – 1 June 1995

Raymond S. Koff – 1 June 1995