Michio Morimoto, Ann‐Louise Hagbjörk, Yu‐Jui Yvonne Wan, Paul C. Fu, Paolo Clot, Emanuele Albano, Magnus Ingelman‐Sundberg, Samuel W. French – 1 June 1995 – This study was done to determine if a relationship exists between CYP2E1 induction by ethanol, lipid peroxidation, and liver pathology in experimental alcohol‐induced liver disease in the rat. Rats were fed ethanol with or without diallyl sulfide (DAS) or phenethyl isothiocyanate (PIC) intragastrically for 1 month.

Emanuel K. Manesis, Gregory Giannoulis, Pavlos Zoumboulis, Irini Vafiadou, Stephanos J. Hadziyannis – 1 June 1995 – We tested the hypothesis that a combination of sex hormone suppression and inhibition of their target receptors might improve survival for patients with hepatocellular carcinoma (HCC).

Marjut Ranki, Hermann M. Schätzl, Reinhart Zachoval, Mikko Uusi‐Oukari, Päivi Lehtovaara – 1 June 1995 – A new standardized test for hepatitis B virus (HBV) DNA with increased sensitivity and range over previous assays (30 to 106 HBV genomes/test) was evaluated in this study. The quantitative results from the test have been validated using international reference specimens of known titer and a reference solution hybridization test. The test has small variability considering the wide dynamic range. The CV was 14% within one experiment and 32% to 39% between independent experiments.

Takahito Adachi, Shigeru Nakashima, Shigetoyo Saji, Toshikazu Nakamura, Yoshinori Nozawa – 1 June 1995 – Hepatocyte growth factor (HGF) and epidermal growth factor (EGF)—stimulated DNA synthesis in primary cultured rat hepatocytes. HGF‐induced DNA synthesis was concentration‐dependently inhibited by a cyclooxygenase inhibitor, indomethacin. BW755C, a dual inhibitor for cyclooxygenase and lipoxygenase activities, also inhibited hepatocyte growth.

Jan W. A. Smit, Karel J. Van Erpecum, Willem Renooij, Mark F. J. Stolk, Patrick Edgar, Heleen Doornewaard, Gerard P. Vanberge‐Henegouwen – 1 June 1995 – 3‐hydroxy, 3‐methylglutaryl coenzyme A (HMG‐CoA) reductase inhibitors reduce biliary cholesterol saturation index (CSI) in duodenal bile in hypercholesterolemic patients and might be useful for gallstone dissolution. However, preliminary data suggest that these drugs are not effective in this respect. We therefore studied 33 patients with radiolucent gallstones in an opacifying gallbladder who were scheduled for elective cholecystectomy.

Bernardo Frider, Silvia Sookoian, Gustavo Castano, G. Giavino, Edgardo Chouela, Jean‐Michel Pawlotsky, Daniel Dhumeaux – 1 June 1995

Andrea Fabbri, Giampaolo P. Bianchi, Guilio Marchesini – 1 June 1995

Sui‐Min Qiu, Gary Wen, Julie Wen, Roger D. Soloway, Roger S. Crowther – 1 June 1995 – Calcium hydroxyapatite (HAP) crystals formed in vitro in the presence of polymeric human gallbladder mucin (1.0 mg/mL) were smaller (0.75 ± 0.39 μm) than control crystals (7.86 ± 2.76 μm), but the mucin did not affect the kinetics of crystal formation or alter the amount of mineral phase present at equilibrium. In contrast, glycopeptide subunits produced by proteolysis of the native mucin had no effect on HAP crystal size.

Walter F. Grigioni, Michelangelo Fiorentino, Antonia d'Errico, Antonio Ponzetto, Tiziana Crepaldi, Maria Prat, Paolo M. Comoglio – 1 June 1995 – The c‐met protooncogene encodes a 190‐kd transmembrane tyrosine kinase. This molecule is the receptor for the hepatocyte growth factor (HGF), which is an important mitogen for hepatocytes both in vitro and in vivo. In experimental models, the c‐met transcripts appeared strongly expressed by actively proliferating oval cells (OCs).

Lucile Musset, François Lunel, Patrice Cacoub, Paul‐Regis Mannant, Christine Silvain, Corinne Lacombe, Pierre Opolon, Jean‐Louis Preud'homme – 1 June 1995