Andreas K. Nussler, Mauricio Di Silvio, Zhi‐Ze Liu, David A. Geller, Paul Freeswick, Kenneth Dorko, Fabio Bartoli, Timothy R. Billiar – 1 June 1995 – Marked differences in induced nitric oxide (NO) synthesis occur between species. We have previously shown that both human and rat hepatocytes express an inducible NO synthase in response to cytokines and lipopolysaccharide. In this study, we compare the expression and regulation of cytokine‐induced NO synthase in hepatocytes isolated from three species, human, rat, and mouse.

Ming‐Chih Hou, Han‐Chieh Lin, Benjamin Ing‐Tiau Kuo, Chen‐Hsiang Chen, Fa‐Yauh Lee, Shou‐Dong Lee – 1 June 1995 – To determine the efficacy of endoscopic variceal sclerotherapy (EVS) and ligation (EVL) in the management of esophageal variceal bleeding, 134 cirrhotic patients were randomized to receive either treatment. The clinical and endoscopic characteristics were similar in both groups. Active bleeding was controlled with ligation (20 of 20) as efficiently as with sclerotherapy (14 of 16).

Ulrich Stölzel, Erich Köstler, Christiane Koszka, Maricka Stöffler‐Meilicke, Detlef Schuppan, Rajan Somasundaram, Manfred O. Doss, Karl O. Habermehl, Ernst O. Riecken – 1 June 1995 – Previous studies from Spain, Italy, and France have demonstrated a high prevalence (71% to 91%) of antibodies against hepatitis C virus in patients with porphyria cutanea tarda (PCT). To determine the role of hepatitis C virus (HCV) in PCT in Germany, we have assessed the prevalence of antibodies against HCV and hepatitis B virus (HBV) in 106 patients (mean age, 60 ± 14 years) with the disease.

Karin Blakolmer, Kasimirsz Jaskiewicz, Harold A. Dunsford, Simon C. Robson – 1 June 1995 – The identification of ductal plate cells as likely progenitors for bile duct epithelium and hepatocytes and their possible reappearance as oval cells in the regenerating liver have generated much interest in their pluri‐potential capacities. We have examined the distribution of three hematopoietic stem cell markers, c‐kit, CD34, and CD33 in addition to laminin, the standard cytokera‐tin markers CAM 5.2, CK 18, and CK 7 and the oval cell marker OV‐6 in fetal liver during various stages of development.

1 June 1995

Pietro Andreone, Carmela Cursaro, Annagiulia Gramenzi, Maria Silvia Guidetti, Frederico Bardazzi, Antonella Tosti, Rita Miniero, Silvia Fargion – 1 June 1995

Raymond S. Koff – 1 June 1995

Josef E. Fischer – 1 June 1995

Wendy M. Mars, Meng‐Lun Liu, Richard P. Kitson, Ronald H. Goldfarb, Megan K. Gabauer, George K. Michalopoulos – 1 June 1995 – Hepatocyte growth factor (HGF), also known as scatter factor, is believed to play a primary role in liver regeneration. HGF is produced in an inactive single‐chain form that can be cleaved in vitro to the active two‐chain form by tissue‐type and urokinase‐type plasminogen (PLG) activators (tPA and uPA).

Clifford A. Brass, Arnold Kooij, Wilma M. Frederiks, Cornelis J. F. Van Noorden – 1 June 1995