Shao‐Nan Huang, Francis V. Chisari – 1 March 1995 – Hepatocyte turnover rates were studied in two lineages of transgenic mice that overproduce the hepatitis B virus (HBV) large envelope protein and retain filamentous hepatitis B surface antigen (HBsAg) particles in the endoplasmic reticulum, resulting in the formation of ground glass hepatocytes. The high producer lineage (50‐4) develops a necroinflammatory liver disease that progresses to hepatocellular carcinoma (HCC), whereas the low producer lineage (107‐5) displays no histopathologic changes other than ground glass hepatocytes.

Adolfo Francesco Attili, Adriano de Santis, Rita Capri, Anna Maria Repice, Silvana Maselli, Grepco Group – 1 March 1995 – During the cross‐sectional studies (February 1981 to July 1984) performed by the Group for Epidemiology and Prevention of Cholelithiasis (GREPCO) in Rome, Italy, 161 subjects were identified as having gallstones. Ten subjects did not participate in the prospective follow‐up. At entry, 33 of the 151 remaining subjects were symptomatic, and 118 were asymptomatic.

John G. Lee, Stephen M. Schutz, Ruth E. England, Joseph W. Leung, Peter B. Cotton – 1 March 1995 – The efficacy of endoscopic treatment in primary sclerosing cholangitis has not been clearly established. This report presents endoscopic intervention in 53 consecutive patients with this disorder. Pertinent data were abstracted from the GI‐TRAC database, medical records, and cholangiograms, and clinical follow‐up was obtained by telephone interview of the subjects. Assessed treatment outcomes were clinical symptom, liver function test, and cholangiographic appearance.

Germán Soriano, Pere Coll, Carlos Guarner, José Such, Ferran Sánchez, Guillem Prats, Francisco Vilardell – 1 March 1995 – Spontaneous bacterial peritonitis (SBP) is a frequent and severe complication of cirrhosis. Escherichia coli is the most frequent bacterium isolated in this condition. The presence of capsular antigens, mainly the K1 capsular polysaccharide, has been associated with invasiveness in E coli infections. Capsular serotypes of E coli causing SBP were determined in 37 cirrhotic patients.

John K. Ramage, Susan M. Catnach, Roger Williams – 1 March 1995

Doug Routley, John K. Ramage, James McPeake, Kai‐Chah Tan, Roger Williams – 1 March 1995 – The place of orthotopic liver transplantation (OLT) in the management of metastatic hepatic neuroendocrine tumors has not been adequately defined. The present report is concerned with patient survival, disease recurrence, and symptom relief in 11 such patients in a single center who, at the time of transplantation, had no extrahepatic tumor.

Liliane Dubuisson, Liliane Boussarie, Christiane‐Alexine Bedin, Charles Balabaud, Paulette Bioulac‐Sage – 1 March 1995 – The oral administration of selenium (Se) to young rats induces, over a 2‐month period, the formation of nodular regenerative hyperplasia with sinusoidal damage around nodules. Perinodular areas located in zone 1 comprise atrophic hepatocytes and capillarized sinusoids without fibrosis.

Roser Pagan, Miquel Llobera, Senén Vilaró – 1 March 1995 – When hepatocyte‐enriched fractions from neonatal rat livers were cultured for different times in the absence of added growth factors, a population of highly proliferating and migrating fibroblastlike cells appeared. Double immunofluorescence with antibodies to cytokeratin and to vimentin showed a progressive reduction in the number of cytokeratin‐positive cells parallel to an increase in the vimentin‐positive cells. Some cells with transitional epithelial or migrating morphology coexpressed both intermediate filament proteins.

Abraham P. Bautista, John J. Spitzer – 1 March 1995 – This work is based on the hypothesis that low‐dose lipopolysaccharide (LPS) suppresses the stimulatory and priming effects of a subsequent high‐dose endotoxin on the formation of toxic oxygen‐derived radicals by the perfused liver and isolated hepatic nonparenchymal cells. Such effects may in turn contribute to hyposensitivity to the lethal effect of large doses of endotoxin.

Juergen Mueller, Emmet B. Keeffe, Carlos O. Esquivel – 1 March 1995 – Giant hepatocellular adenomas are associated with a high incidence of rupture with intraabdominal hemorrhage and may also undergo malignant transformation. If resection is not technically feasible, liver transplantation should be a treatment option. The aim of this report is to describe the indications, feasibility, and outcome of liver transplantation for hepatocellular adenomas.