Per Stål, Rolf Hultcrantz, Lennart Möller, Lennart C. Eriksson – 1 February 1995 – The aim of this study was to evaluate the effects of dietary iron on hepatocarcinogenesis in an animal model mimicking noncirrhotic genetic hemochromatosis. Iron overload may lead to liver cirrhosis and an increased risk of developing primary hepatocellular carcinoma. It is unknown if iron is of pathogenic importance for the carcinogenic process, or whether the increased cancer risk results solely from the cirrhotic process.

Cheryl Hanau, Santiago J. Munoz, Raphael Rubin – 1 February 1995 – The clinicopathological features of 38 patients admitted consecutively for fulminant hepatic failure were studied. Histopathological material was reviewed in all patients. Both percutaneous and whole livers (either explanted or autopsy specimens) were available in 16 patients: whole livers only in 12 patients and biopsy specimens only in 10 patients. All patients were negative for antibodies to hepatitis C, whereas 24% had hepatitis B infection and 10% had adverse drug reactions.

Domenico Sansonno, Vito Cornacchiulo, Anna Rina Iacobelli, Rita Di Stefano, Mario Lospalluti, Franco Dammacco – 1 February 1995 – Skin and/or liver biopsy specimens were obtained from the following patients: 15 anti–hepatitis C virus (HCV), HCV RNA–positive patients and 3 anti‐HCV, HCV RNA–negative patients with type II mixed cryoglobulinemia (MC); 7 anti‐HCV, HCV RNA–positive patients with chronic active liver disease (CALD); 5 anti‐HCV, HCV RNA–negative patients with noncryoglobulinemic vasculitis; and 7 anti‐HCV, HCV RNA–negative patients with lichen ruber planus.

Mark B. Sostek – 1 February 1995

Josefa Ros, Wladimiro Jiménez, Santiago Lamas, Joan Clària, Vicente Arroyo, Francisca Rivera, Joan Rodés – 1 February 1995 – Indirect evidence exists implicating vascular nitric oxide in the pathogenesis of arterial vasodilation in cirrhosis. In the current study, a coincubation assay to estimate the vascular nitric oxide production was developed and the nitric oxide production by arterial segments of cirrhotic and control rats was assessed.

Carlo Sabbà, Carlo Merkel, Marco Zoli, Giovanna Ferraioli, Stefano Gaiani, David Sacerdoti, Luigi Bolondi – 1 February 1995 – The aim of this study was to assess the interobserver, interequipment, and time‐dependent variabilities of echo‐Doppler measurements of portral blood flow velocity (PBV), portal vein diameters (PVDs) and their derived parameters, portal blood flow (PBF), and congestion index (CI) in cirrhotic patients. The influence of a cooperative training program of the opeators on the reproductibility of the results was also investigated.

Siddhartha Kar, Brian I. Carr – 1 February 1995 – A large percentage of patients with advanced‐stage hepatocellular carcinoma (HCC) have a recurrence of tumor in the liver or lung after primary resection and even after orthotopic liver transplantation. One reason for this may be the presence of small numbers of tumor cells circulating in the blood before surgery or the liberation of tumor cells into circulation during surgical manipulation.

Enrico Silini, Fulvia Bono, Agostino Cividini, Antonella Cerino, Savino Bruno, Sonia Rossi, Giovanni Belloni, Bruno Brugnetti, Emilio Civardi, Laura Salvaneschi, Mario U. Mondelli – 1 February 1995 – Hepatitis C virus (HCV) infection persists for an indefinite length of time in a major proportion of patients, inducing chronic liver lesions that evolve to cirrhosis and hepatocellular carcinoma (HCC) in approximately 20% of cases. We studied HCV viremia and genotypes by reverse transcription–polymerase chain reaction (RT‐PCR) in 341 consecutive anti‐HCV–positive patients.

Hugo O. Jauregui, Claudy J‐P. Mullon, Donna Trenkler, Sharda Naik, Henry Santangini, Philip Press, Thomas E. Muller, Barry A. Solomon – 1 February 1995 – Orthotopic liver transplantation is the only effective form of therapy currently available for patients with fulminant hepatic failure (FHF). The use of an extracorporeal (EC) liver assist device (LAD) may result in improved presurgical clinical management.

Paul J. Thuluvath, David Edwin, Nancy Chang Yue, Cora Devilliers, Sandra Hochman, Andrew Klein – 1 February 1995 – Increased, symmetrical signals of varying intensity in the globus pallidi on T1‐weighted (T1W) images, without corresponding signals on T2‐weighted (T2W) images, have been reported previously in chronic hepatic failure, It has been suggested that these signals are characteristic of chronic hepatic encephalopathy.