Intragraft cytokine gene expression in human liver allografts

Carlos A. Cosenza, Haval Shirwan, Donald V. Cramer, Linda Sher, Luis Podesta, Leonard Makowka – 1 January 1995 – Cytokines are thought to play an important role in the inflammatory and immune responses of allograft rejection. We evaluated the pattern of cytokine gene expression in 36 liver biopsy specimens obtained from 20 recipients of primary orthotopic liver allografts.

Non‐ABCDE hepatitis: IS there another enterically transmitted hepatitis virus?

Eric E. Mast, Michael A. Purdy – 1 January 1995 – Many epidemics of water‐borne hepatitis have occurred throughout India. These were thought to be epidemics of hepatitis A until 1980, when evidence for an enterically transmitted non‐A, non‐B hepatitis was first reported. Subsequently, hepatitis E virus was discovered and most recent epidemics of enterically transmitted non‐A, non‐B hepatitis have been attributed to hepatitis E virus infection. However, only a limited number of cases have been confirmed by immuno electron microscopy, polymerase chain reaction, or seroconversion.

Uw‐preservation of cultured human gallbladder epithelial cells: Phenotypic alterations and differential mucin gene expression in the presence of bile

Jean‐Pierre Campion, Nicole Porchet, Jéan‐Pierre Aubert, Annie L'Helgoualch, Bruno Clément – 1 January 1995 – In orthotopic liver transplantation, extended cold ischemia of the graft may induce cell damage, particularly in biliary epithelium. We have investigated the effects of a cold University of Wisconsin (UW) solution on cultured human gallbladder biliary epithelial cells (GBEC) exposed or not exposed to stagnant bile. In UW solution, morphological alterations of cultured GBEC were not prominent under light microscopy after 16 hours at 4°C, being more striking after 24 to 48 hours.

Feeding S‐adenosyl‐l‐methionine attenuates both ethanol‐induced depletion of mitochondrial glutathione and mitochondrial dysfunction in periportal and perivenous rat hepatocytes

Carmen García‐Ruiz, Albert Morales, Anna Colell, Antonio Ballesta, Joan Rodés, Neil Kaplowitz, José C. Fernández‐Checa – 1 January 1995 – Mitochondrial glutathione plays an important role in maintaining a functionally competent organelle. Previous studies have shown that ethanol feeding selectively depletes the mitochondrial glutathione pool, more predominantly in mitochondria from perivenous hepatocytes.

Long‐term effects of cholecystectomy on bile acid metabolism

Gerd‐Achim Kullak‐Ublick, Gustav Paumgartner, Frieder Berr – 1 January 1995 – Comparative studies between different patient groups have suggested that cholecystectomy enhances bacterial dehydroxylation of the primary bile acid cholic acid (CA) to the secondary bile acid deoxycholic acid (DCA). DCA may exert a cocarcinogenic effect on the colonic mucosa. In a short‐term follow‐up study on nine female patients we found no alterations of the CA or DCA pools after cholecystectomy.

Predictive value of precore hepatitis B virus mutations in spontaneous and interferon‐induced hepatitis B e antigen clearance

Anna S. F. Lok, Ulus S. Akarca, Sheila Greene – 1 January 1995 – We previously reported two mutually exclusive mutations in the precore region of hepatitis B virus: M1 (T‐1856, proline‐serine substitution at codon 15) and M2 (A‐1896, stop codon at codon 28). This study was conducted to determine if the presence of precore mutants affect spontaneous or interferon (IFN)‐induced hepatitis B e antigen (HBeAg) clearance.

Analysis of the precore DNA sequence and detection of precore antigen in liver specimens from patients with anti‐hepatitis b e—positive chronic hepatitis

Hans Peter Dienes, Guido Gerken, Bernd Goergen, Klaus Heermann, Wolfram Gerlich, K. H. Meyer zum Büschenfelde – 1 January 1995 – A number of naturally occurring hepatitis B virus (HBV) mutants unable to synthesize the hepatitis B e antigen (HBeAg) have been identified in patients characterized by HBV DNA and anti‐HBe in their serum. Because the analysis of the HBV‐associated DNA and antigens in the liver tissue is still not complete, we investigated the precore sequence of HBV DNA and its encoded proteins in the liver tissue of 32 patients positive for HBV DNA and anti‐HBe in their serum.

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