The role of sodium in the uptake of ursodeoxycholic acid in isolated hamster hepatocytes

Bernard Bouscarel, Robert Nussbaum, Howard Dubner, Hans Fromm – 1 January 1995 – The uptake of ursodeoxycholic acid (UDCA) was studied in isolated hamster hepatocytes. The uptake was rapid and linear up to 60 seconds for each concentration studied. When the uptake rate was plotted against UDCA concentration, the curve was nonlinear, indicating both saturable and nonsaturable uptake mechanisms. The nonsaturable process had a diffusion constant of 0.01 nmol·s–1·g of cell·μmol/L–1.

Increased gene expression of water channel in cirrhotic rat kidneys

Yasuhiro Asahina, Namiki Izumi, Nobuyuki Enomoto, Sei Sasaki, Kiyohide Fushimi, Fumiaki Marumo, Chifumi Sato – 1 January 1995 – In patients with liver cirrhosis, impaired water and sodium excretion has been incriminated in the pathogenesis of ascites formation. Increased reabsorption of water in the distal nephron has been shown to play an important role in water retention in cirrhotic rat kidneys. Recently, a complementary DNA (cDNA) for the vasopressin‐regulated water channel (the aquaporin of the apical membrane of the kidney collecting duct [AQP‐CD]) has been cloned.

Diseases of the liver and biliary tract. Standardization of nomenclature, diagnostic criteria and prognosis. Edited by Carroll M. Leevy, Sheila Sherlock, Neils Tygstrup, and Rowen Zetterman, 205 pp. New York: Raven Press, 1994. $40

Selective transmission of variant genomes from mother to infant in neonatal fulminant hepatitis B

Fritz Von Weizsäcker, Irmgard Pult, Katja Geiss, Stefan Wirth, Hubert E. Blum – 1 January 1995 – Hepatitis B virus (HBV) nucleotide sequences isolated from mother/child pairs were analyzed in three cases of neonatal fulminant hepatitis B (FHB). Heterogeneous HBV sequences consistent with both adw2 and ayw subtype were found in all three mothers. In one case, in which the child survived, both subtypes were transmited. By contrast, only the ayw subtype was present in the two other children with a fatal course of FHB.

Determination of hepatitis delta virus RNA by polymerase chain reaction in acute and chronic delta infection

Rosendo Jardi, Maria Buti, Montserrat Cotrina, Francisco Rodriguez, Helena Allende, Rafael Esteban, Jaime Guardia – 1 January 1995 – The objective of this study was to evaluate the usefulness of hepatitis delta virus (HDV) RNA detection by polymerase chain reaction (PCR) in acute and chronic D hepatitis and to correlate with HDV‐RNA detection by dot blot and hepatic delta antigen.

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