Anti‐liver cytosolic antigen type 1 (LC1) antibodies in childhood autoimmune liver disease

Shuhua Han, Micheal Tredger, Germana V. Gregorio, Giorgina Mieli‐Vergani, Diego Vergani – 1 January 1995 – Antibodies to liver cytosol antigen type 1 (anti‐LC1), which recognize a 60‐kd peptide contained in the liver cytosolic fraction, have been reported to define a subset of autoimmune hepatitis (AIH) either negative for other autoantibodies or positive for anti‐liver kidney microsomal antibody type 1 (LKM‐1) and to be best detected in immunodiffusion.

Hepatitis B virus precore mutant infection is associated with severe recurrent disease after liver transplantation

Peter W. Angus, Stephen A. Locarnini, Geoffrey W. McCaughan, Robert M. Jones, Janine S. McMillan, D. Scott Bowden – 1 January 1995 – The factors that predispose patients undergoing liver transplantation for hepatitis B virus (HBV) disease to severe recurrence of infection are unclear. In this study we examined the effect of pretransplantation infection with HBV and precore variant strains of HBV on posttransplantation outcome and allograft histology in 24 patients who survived more than 3 months after liver transplantation.

Effect of deoxycholate on immunoglobulin G concentration in bile: Studies in humans and pigs

Juan R. Sanabria, Aravinda Upadhya, Brendan Mullen, P. Robert C. Harvey, Steven M. Strasberg – 1 January 1995 – Because an increase in biliary deoxycholate levels seems to be a risk factor for cholesterol gallstone formation, we determined the relationship between deoxycholate levels and levels of the pronucleating protein, immunoglobulin G (Ig) in human gallbladder bile. Patients with cholesterol gallstones had a higher concentration of biliary IgG compared with a pigmented stone group and control patients.

Employment after liver transplantation

Paul C. Adams, Cameron N. Ghent, David R. Grant, William J. Wall – 1 January 1995 – The objective of this study was to study the factors affecting employment after liver transplantation. The employment status and health status of 203 adult liver transplant recipients was assessed retrospectively in a survey comprising an employment questionnaire, the Sickness Impact Profile (SID), and the Medical Outcomes Survey (MOS).

Pediatric liver transplantation for langerhans' cell histiocytosis

Parissa Zandi, Yves Panis, Dominique Debray, Olivier Bernard, Didier Houssin – 1 January 1995 – Langerhans' cell histiocytosis (LCH) represents 15% to 20% of sclerosing cholangitis (SC) in children. In LCH‐associated SC, a very poor response to chemotherapy has been reported, and spontaneous prognosis is very bad. Few cases of orthotopic liver transplantation (OLT) for LCH have been reported and little is known about the risk of recurrence and the effect of immunosuppression after OLT. Since 1986, five children (mean age ± SD, 12.6 ± 3.6 years) underwent OLT for SC complicating LCH.

Occurrence of hepatocellular carcinoma and decompensation in western european patients with cirrhosis type B

Giovanna Fattovich, Giuliano Giustina, Solko W. Schalm, Stephanos Hadziyannis, Josè Sanchez‐Tapias, Piero Almasio, Erik Christensen, Kim Krogsgaard, Francoise Degos, Miguel Carneiro De Moura, Antonio Solinas, Franco Noventa, Giuseppe Realdi – 1 January 1995 – To examine the morbidity of compensated cirrhosis type B, a cohort of 349 Western European, white patients (86% men; mean age, 44 years) with biopsy‐proven cirrhosis was followed up for a mean period of 73 months and was studied for occurrence of hepatocellular carcinoma (HCC) and decompensation.

Intragraft cytokine gene expression in human liver allografts

Carlos A. Cosenza, Haval Shirwan, Donald V. Cramer, Linda Sher, Luis Podesta, Leonard Makowka – 1 January 1995 – Cytokines are thought to play an important role in the inflammatory and immune responses of allograft rejection. We evaluated the pattern of cytokine gene expression in 36 liver biopsy specimens obtained from 20 recipients of primary orthotopic liver allografts.

Subscribe to