Francesco Negro, Ferruccio Bonino, Adrian Di Bisceglie, Jay H. Hoofnagle, John L. Gerin – 1 December 1989 – The intrahepatic distribution of hepatitis delta virus RNA was studied by in situ hybridization in 33 formalin‐fixed, paraffin‐embedded biopsies from 17 chronic hepatitis B virus carriers superinfected with hepatitis delta virus. The findings were correlated with the expression of the hepatitis delta antigen, the duration of the hepatitis delta virus infection and the eosinophilic degeneration of the hepatocytes.

Johannes Bircher, Charles M. A. Bijleveld, Roel J. Vonk, Folkert Kuipers – 1 December 1989

Adrian M. di Bisceglie, Francesco Negro – 1 December 1989

1 December 1989

Elwyn Elias, Rosemary Waring – 1 December 1989

Claudio Tiribelli, Mauro Melato, Lory S. Crocè, Luigi Giarelli, Kunio Okuda, Kunihiko Ohnishi – 1 December 1989 – A comparative, descriptive study on the prevalence of hepatocellular carcinoma either associated or not with cirrhosis was undertaken between the cities of Trieste, Italy, and Chiba, Japan. Data were derived from 12,340 and 2,052 autopsies consecutively performed in Trieste and Chiba during 1980 to 1984 and 1975 to 1985, respectively. During these years, more than 70% of all deaths were studied by autopsy in Trieste.

Mayumi Hasegawa, Sadako Yamada, Chisato Hirayama – 1 December 1989 – Fasting plasma caffeine concentrations, plasma levels of catecholamines and plasma renin activity were measured in patients with cirrhosis and control patients without hepatic dysfunction. A careful dietary history showed no significant difference in caffeine consumption (mean ± S.E.) among 46 cirrhotics (86 ± 7 mg per day) vs. 34 control patients (91 ± 8 mg per day).

Jaime Bosch, Roberto J. Groszmann, Joan C. García‐Pagán, Josep Terés, Guadalupe García‐Tsao, Miquel Navasa, Antoni Mas, Joan Rodés – 1 December 1989 – The aim of this study was to evaluate, using a doubleblind technique, the efficacy of the association of transdermal nitroglycerin to vasopressin infusion for the treatment of variceal bleeding.

Jorge E. Valenzuela, Timothy Schubert, M. Ronald Fogel, Richard M. Strong, Joel Levine, Peter R. Mills, Thomas L. Fabry, Linda W. Taylor, Harold O. Conn, James T. Posillico, A Multicenter Study Group – 1 December 1989 – A prospective, randomized, placebo‐controlled, double‐blind, multicenter clinical trial of intravenous somatostatin (Stilamin®; Serono Laboratories, Inc., Randolph, MA) was performed in 102 patients with actively bleeding esophageal varices from August, 1985, to November, 1986.

Ricardo Mastaï, P.‐Michel Huet, Antoine Brault, Jocelyne Belgiorno – 1 December 1989 – It has been suggested that hepatocyte enlargement can lead to compression of the extracellular space (sinusoidal and interstitial) and induce portal hypertension. However, this hypothesis has never been tested by measuring the vascular and extravascular spaces in the intact liver. The aim of the present study was to investigate the effects of chronic alcohol intake on the hepatic microcirculation using Goresky's multiple‐indicator dilution technique in the isolated perfused rat liver.