Robert S. Britton, Rosemary O'Neill, Bruce R. Bacon – 1 January 1990 – Peroxidative decomposition of mitochondrial membrane phospholipids with subsequent mitochondrial dysfunctin is a postulated mechanism of liver cell injury in parenchymal iron overload. Malondialdehyde is formed when polyunsaturated fatty acids of membrane phospholipids undergo peroxidative decomposition, and it is metabolized by aldehyde dehydrogenase. We studied mitochondrial metabolism of malondialdehyde in rats with chronic dietary iron overload.

Jill E. Maddison, Dorothy K. Leong, Peter R. Dodd, Graham A. R. Johnston – 1 January 1990 – Significant discrepancy exists between radioreceptor and high‐performance liquid chromatographic estimates of plasma GABA concentrations in animal models of hepatic encephalopathy. A possible explanation for this discrepancy is the presence in plasma of a substance that can inhibit [3H]‐GABA binding but is not GABA itself.

Yvon Calmus, Pierre Gane, Philippe Rouger, Raoul Poupon – 1 January 1990 – Aberrant hepatic expression of HLA molecules has been shown to be present in primary biliary cirrhosis and may play a determining role in the pathogenesis of the disease. We have studied the effect of the long‐term administration of ursodeoxycholic acid on hepatic HLA expression. Nine untreated patients with primary biliary cirrhosis, eight patients treated for at least a year with ursodeoxycholic acid and eight control subjects without hepatobiliary disease were compared.

Harold S. Margolis, Omana V. Nainan – 1 January 1990 – Circulating immune complexes were isolated by conglutinin affinity chromatography during the course of hepatitis A virus infection in a chimpanzee. Characterization of circulating immune complexes showed that most of the hepatitis A virus‐specific antibody was IgM, that IgG was present and that C3d and fibronectin were also present.

Daisaku Muno, Eiki Kominami, Hideo Ishii, Koh Usui, Koji Saifuku, Yuji Sakakibara, Toshihiko Namihisa – 1 January 1990 – Most of the sera from patients with primary biliary cirrhosis contains antimitochondrial antibodies, which react with four proteins of the mitochondrial inner membrane. We reported in a previous paper that when beef heart mitochondrial inner membrane proteins were digested by trypsin, a new reactive 36 kDa fragment with antimitochondrial antibody was obtained.

Francis R. Weiner, Marie‐Adele Giambrone, Mark J. Czaja, Anish Shah, Giorgio Annoni, Shizuko Takahashi, Mahboubeh Eghbali, Mark A. Zern – 1 January 1990 – Ito cells are perisinusoidal cells thought to be a major source of collagen in normal and fibrotic livers. These cells appear to have features similar to several cell types but when cultured assume a fibroblast‐like morphology. In this study we evaluated the phenotype of both freshly isolated and cultured Ito cells by examining their gene expression.

Samuel A. Ockner, Elizabeth M. Brunt, Steven M. Cohn, Elaine S. Krul, Douglas W. Hanto, Marion G. Peters – 1 January 1990 – A previously healthy 35‐year‐old woman was seen at 37 weeks' gestation with a 10‐day history of fever, vomiting, diarrhea and malaise. Serum laboratory findings included elevation of serum bilirubin and AST, prolongation of serum prothrombin time and a positive monospot. A tentative diagnosis of acute fatty liver of pregnancy was made, and a healthy male infant was delivered by emergency cesarean section because of fetal distress.

Tsung‐Sheng Su, Ting‐Fen Tsai, Chin‐Wen Chi, Shou‐Hwa Han, Chen‐Kung Chou – 1 January 1990 – Complementary DNA of a rat brain glucose transporter gene was used to examine the expression of glucose‐transporter messenger RNA in paired human hepatocellular carcinomas and adjacent nontumorous liver tissues, as well as in human hepatoma cell lines and human fetal liver samples. High expression of a major 2.8‐kilobase glucose‐transporter transcript was seen in all hepatoma cell lines and fetal liver samples examined, whereas a much lower level of expression was observed in liver tissues.

Paul Calabresi, Gregory Curt – 1 January 1990 – Fourteen patients received 5‐iodo‐2 ‐deoxyuridine (IdUrd) before surgery for placement of a hepatic arterial catheter. Biopsy specimens were obtained at the time of surgery and the incorporation of IdUrd into DNA in tumor and normal hepatic tissue was measured by high‐performance liquid chromatography and used as an index of drug selectivity. Over a 3‐day intravenous infusion of IdUrd at 1,000 mg/m2/day, substitution for thymidine in tumor DNA averaged 3.1%. Normal hepatic DNA contained <1% substitution by IdUrd.

Ranjit Banerjee, Saul Karpen, Miriam Siekevitz, Gabriella Lengyel, Joachim Bauer, George Acs – 1 December 1989 – Tumor necrosis factor‐α is an inducer of acute‐phase protein synthesis in liver cells. The mechanism by which tumor necrosis factor‐α alters gene expression in these cells is largely unknown. In this study, we demonstrate that tumor necrosis factor‐α stimulates human immunodeficiency virus‐1 long terminal repeat‐promoted gene expression in the human hepatoblastoma HepG2 cell line and increased binding of trans‐activating factors to kappa B (kB) DNA sequences.