Graft‐vs.‐host disease after liver transplantation

Graeme Alexander, Bernard Portmann – 1 January 1990 – Clinically evident, generalized graft‐vs.‐host disease is not thought to occur as a consequence of transplantation of most solid organs. The large inoculum of donor lymphoid cells required and the inability of the recipient to destroy these passenger cells are apparently rarely produced by solid‐organ transplantation. However, there is a risk of graft‐vs.‐host disease when normal spleens are included in vascularized pancreas transplants.

Quantitative analysis of pre‐S1 and pre‐S2 in relation to HBsAg expression

Nobukazu Yuki, Norio Hayashi, Kazuhiro Katayama, Akinori Kasahara, Keiji Ueda, Hideyuki Fusamoto, Nobuhiro Sato, Takenobu Kamada – 1 January 1990 – Sera from four patients with acute hepatitis B and 87 patients with chronic hepatitis B were examined quantitatively for pre‐S1 and pre‐S2 antigens by solid‐phase enzyme immunoassays. Pre‐S1 and pre‐S2 antigens were detected in HBsAg‐positive sera irrespective of the presence of viral replicative markers, and their titers correlated with those of HbsAg(r = 0.74, p < 0.01; r = 0.74, p < 0.01, respectively).

In Vivohepatic energy metabolism during the progression of alcoholic liver disease: A noninvasive 31p nuclear magnetic resonance study in rats

Hisao Takahashi, Yves Geoffrion, Keith W. Butler, Samuel W. French – 1 January 1990 – We investigated serially in vivo the rations of phorylated metabolites and the intracellular PH in the livers of rats fed ethanol chronically to evaluate the relation between changes in energy metabolism and the progression of alcoholic liver disease with 31P nuclear magnetic resonance spectroscopy.

Bile concentration is a key factor for nucleation of cholesterol crystals and cholesterol saturation index in gallbladder bile of gallstone patients

Karel J. Van Erpecum, Gerard P. Berge Van Henegouwen, Bregt Stoelwinder, Yvonne M. G. Schmidt, Frans L. H. Willekens – 1 January 1990 – We investigated whether bile concentration influenced cholesterol saturation index or nucleation time of cholesterol monohydrate crystals in a large number of gallbladder bile samples. Pigment stone patients never had cholesterol crystals in their fresh biles, and nucleation time was always longer than 20 days. Of the cholesterol stone patients 79% had cholesterol crystals in their fresh biles.

Amiodarone‐ and desethylamiodarone‐induced myelinoid inclusion bodies and toxicity cultured rat hepatocytes

Pitambar Somani, Subhankar Bandyopadhyay, James E. Klaunig, Susan A. Gross – 1 January 1990 – Hepatocytes isolated from Sprague‐Dawley rats were incubated with various concentrations of either amiodarone or desethylamiodarone fro 0 to 69 hr. Both drugs produced a concentration‐dependent increase of lactate dehydrogenase release in the culture medium, which correlated well with cell death as measured by trypan blue exclusion test. Desethylamiodarone was more toxic than amiodarone in the cultured hepatocytes.

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