Extrahepatic replication of duck hepatitis b virus: More than expected
Kazuhiko Hosoda, Masao Omata, Katsuo Uchiumi, Fumio Imazeki, Osamu Yokosuka, Yoshimi Ito, Kunio Okuda, Masao Ohto – 1 January 1990 – Replication of duck hepatitis B virus in extrahepatic tissue such as pancreas, kidney and spleen has been well documented. To assess whether there is more widespread extraheptic virus replication, we assayed brain, heart, lung, thymus, pancreas, kidney, spleen and intestine of 1‐ to‐wk‐old ducklings for the presence of duck hepatitis B virus DNA and mRNA by blotting in in situ methods.