Amiodarone‐ and desethylamiodarone‐induced myelinoid inclusion bodies and toxicity cultured rat hepatocytes

Pitambar Somani, Subhankar Bandyopadhyay, James E. Klaunig, Susan A. Gross – 1 January 1990 – Hepatocytes isolated from Sprague‐Dawley rats were incubated with various concentrations of either amiodarone or desethylamiodarone fro 0 to 69 hr. Both drugs produced a concentration‐dependent increase of lactate dehydrogenase release in the culture medium, which correlated well with cell death as measured by trypan blue exclusion test. Desethylamiodarone was more toxic than amiodarone in the cultured hepatocytes.

Extrahepatic replication of duck hepatitis b virus: More than expected

Kazuhiko Hosoda, Masao Omata, Katsuo Uchiumi, Fumio Imazeki, Osamu Yokosuka, Yoshimi Ito, Kunio Okuda, Masao Ohto – 1 January 1990 – Replication of duck hepatitis B virus in extrahepatic tissue such as pancreas, kidney and spleen has been well documented. To assess whether there is more widespread extraheptic virus replication, we assayed brain, heart, lung, thymus, pancreas, kidney, spleen and intestine of 1‐ to‐wk‐old ducklings for the presence of duck hepatitis B virus DNA and mRNA by blotting in in situ methods.

The natural history of nonalcoholic steatohepatitis: A follow‐up study of forty‐two patients for up to 21 years

Elizabeth E. Powell, W. Graham E. Cooksley, Reginald Hanson, Jeffrey Searle, June W. Halliday, W. Powell – 1 January 1990 – Forty‐two patients with nonalcoholic steatohepatitis were followed for a median of 4.5 yr (range = 1.5 to 21.5 yr). Except for two patients with lipodystrophy, all were obeser; 35 o f42 were women, 26 of 32 were hyperlipidemic and 15 were hyperglycemic. Upper abdominal pain was the most common reason for presentation.

Endoscopic markers of impending varceal hemorrhage: Correlation with the pressure in the varices

Kazushige Beppu, Makoto Hashizume – 1 January 1990 – In 40 patients with cirrhosis and esophageal varices, transmural variceal pressure was assessed endoscopically by fine needle puncture and related to endoscopicsigns as well as to the severity of liver disease. Transmural pressure was significantly (p < 0.01) higher in the presence of a red color sign (26.7[7.8] cm H2O) than in its absence (19.1 [6.6] cm H2).

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