Extrahepatic replication of duck hepatitis b virus: More than expected

Kazuhiko Hosoda, Masao Omata, Katsuo Uchiumi, Fumio Imazeki, Osamu Yokosuka, Yoshimi Ito, Kunio Okuda, Masao Ohto – 1 January 1990 – Replication of duck hepatitis B virus in extrahepatic tissue such as pancreas, kidney and spleen has been well documented. To assess whether there is more widespread extraheptic virus replication, we assayed brain, heart, lung, thymus, pancreas, kidney, spleen and intestine of 1‐ to‐wk‐old ducklings for the presence of duck hepatitis B virus DNA and mRNA by blotting in in situ methods.

The natural history of nonalcoholic steatohepatitis: A follow‐up study of forty‐two patients for up to 21 years

Elizabeth E. Powell, W. Graham E. Cooksley, Reginald Hanson, Jeffrey Searle, June W. Halliday, W. Powell – 1 January 1990 – Forty‐two patients with nonalcoholic steatohepatitis were followed for a median of 4.5 yr (range = 1.5 to 21.5 yr). Except for two patients with lipodystrophy, all were obeser; 35 o f42 were women, 26 of 32 were hyperlipidemic and 15 were hyperglycemic. Upper abdominal pain was the most common reason for presentation.

Endoscopic markers of impending varceal hemorrhage: Correlation with the pressure in the varices

Kazushige Beppu, Makoto Hashizume – 1 January 1990 – In 40 patients with cirrhosis and esophageal varices, transmural variceal pressure was assessed endoscopically by fine needle puncture and related to endoscopicsigns as well as to the severity of liver disease. Transmural pressure was significantly (p < 0.01) higher in the presence of a red color sign (26.7[7.8] cm H2O) than in its absence (19.1 [6.6] cm H2).

Experimental autoimmune hepatitis: Disease induction, time course and t‐cell reactivity

Ansgar W. Lohse, Michael Manns, Hans‐Peter Dienes, Karl‐Hermann Meyer Zum Büschenfelde, Irun R. Cohen – 1 January 1990 – This study describes a murine model of autoimmune hepatitis: experimental autoimmune hepatitis. Experimental autoimmune hepatitis could be induced most effectively in male C57BL/6 mice by intraperitoneal immunization with the 100,000 g superantant of syngeneic liver homogenate (S‐100) in complete Freund's adjuvant. BALB/C and C3H mice were less susceptible than C57BL/6 mice. Experimental autoimmune hepatitis could not be induced in Lewis rats.

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