Karel J. Van Erpecum, Gerard P. Berge Van Henegouwen, Bregt Stoelwinder, Yvonne M. G. Schmidt, Frans L. H. Willekens – 1 January 1990 – We investigated whether bile concentration influenced cholesterol saturation index or nucleation time of cholesterol monohydrate crystals in a large number of gallbladder bile samples. Pigment stone patients never had cholesterol crystals in their fresh biles, and nucleation time was always longer than 20 days. Of the cholesterol stone patients 79% had cholesterol crystals in their fresh biles.

1 January 1990

1 January 1990

Thomas E. Starzl, Kendrick A. Porter, Ronald W. Busuttil, Rudolph Pichlmayr – 1 January 1990

Hisao Takahashi, Yves Geoffrion, Keith W. Butler, Samuel W. French – 1 January 1990 – We investigated serially in vivo the rations of phorylated metabolites and the intracellular PH in the livers of rats fed ethanol chronically to evaluate the relation between changes in energy metabolism and the progression of alcoholic liver disease with 31P nuclear magnetic resonance spectroscopy.

Nobukazu Yuki, Norio Hayashi, Kazuhiro Katayama, Akinori Kasahara, Keiji Ueda, Hideyuki Fusamoto, Nobuhiro Sato, Takenobu Kamada – 1 January 1990 – Sera from four patients with acute hepatitis B and 87 patients with chronic hepatitis B were examined quantitatively for pre‐S1 and pre‐S2 antigens by solid‐phase enzyme immunoassays. Pre‐S1 and pre‐S2 antigens were detected in HBsAg‐positive sera irrespective of the presence of viral replicative markers, and their titers correlated with those of HbsAg(r = 0.74, p < 0.01; r = 0.74, p < 0.01, respectively).

Graeme Alexander, Bernard Portmann – 1 January 1990 – Clinically evident, generalized graft‐vs.‐host disease is not thought to occur as a consequence of transplantation of most solid organs. The large inoculum of donor lymphoid cells required and the inability of the recipient to destroy these passenger cells are apparently rarely produced by solid‐organ transplantation. However, there is a risk of graft‐vs.‐host disease when normal spleens are included in vascularized pancreas transplants.

Swan N. Thung – 1 January 1990

Robert Scheig – 1 January 1990 – The hepatic sinusoidal endothelium separates sinusoidal blood from hepatocytes; changes in the porosity of this endothelium may affect the passage of chylomicrons into hepatocytes and influence lipid metabolism. Chronic exposure to ethanol reduces the porosity of the endothelium; this mechanism may underlie the hyperlipoprotelium; hyperlipoproteinaemia observed in some people who drink heavily.

James S. Morgan, Roberto J. Groszmann, Marcos Rojkind, Rosa Enriquez – 1 January 1990 – A hamster model of schistosomiasis has provided the first opportunity to sequentially examine the early phases of the development of portal hypertension in a natural model of chronic liver disease.