Barbara M. McFarlane, Jozsef Sipos, Christopher D. Gove, Ian G. McFarlane, Roger Williams – 1 March 1990 – Autoantibodies reacting with the galactose‐specific hepatic asialoglycoprotein receptor—a liver‐specific component expressed on the surfaces of hepatocytes—are often found in patients with chronic active hepatitis of presumed autoimmune origin.
Gary A. Clawson, Julie Sesno, Kathy Milam, Yan‐Fel Wang, Caroline Gabriel – 1 March 1990 – D‐galactosamine produces an early defect in protein synthesis, independent of its effects on RNA synthcsis. Here we show that the defect in protein synthesis is inherent in purified ribosomal subunits in vitro.
Richard W. Light – 1 March 1990 – We reviewed the clinical data, hepatic histology, and microbiological features of 21 patients with previously documented acquired immune deficiency syndrome who had liver biopsies. Diagnoses of specific infections were made on liver biopsy in 11/21 patients (57%). Granulomas were found in 10/21 patients (48%) and were most often a manifestation of infection with Mycobacterium avium‐intracellulare.
Jean D. Grange, Xavier Amiot, Veronique Grange, Laurent Gutmann, Michel Biour, François Bodin, Raoul Poupon – 1 March 1990 – Spontaneous bacterial peritonitis in cirrhosis is a serious complication that demands urgent attention. We report here a prospective study of the treatment of 27 episodes of spontaneous bacterial peritonitis in 22 cirrhotic patients with amoxicillin and clavulanic acid. The infection of ascitic fluid was diagnosed by a positive culture plus an ascitic neutrophil count exceeding 75/μl, or by an ascitic neutrophil count exceeding 500/μl.
Bruno Schneeweiss, Wolfgang Graninger, Peter Ferenci, Sabine Eichinger, Georg Grimm, Barbara Schneider, Anton N. Laggner, Kurt Lenz, Gunter Kleinberger – 1 March 1990 – Energy expenditure and substrate oxidation rate for fat, glucose and protein were evaluated by indirect calorimetry in 20 normal individuals, 35 patients with acute hepatitis and 22 patients with biopsyproven alcoholic cirrhosis in the postabsorptive state. Measurements were done in the resting state after an overnight fast (10 to 12 hr).
Louk H. P. M. Raedemakers, Maud I. Cleton, Carole Kooliman, Harold Baart de La Fajlle, Jan van Hattum – 1 March 1990 – Liver biopsy specimens obtained from two groups of erythrohepatic protoporphyria patients were studied histopathologically and ultrastructurally. Group 1 comprised seven erythrohepatic protoporphyria patients with a normal liver histology; from two patients liver biopsy specimens were available before and after 1 yr of chenodeoxycholic acid treatment.
Äke Danielsson, Lennart Boqvist, Per Uddenfeldt – 1 March 1990 – The northern part of Sweden is sparsely populated and must be regarded as a rural region. An investigation into the incidence and prevalence of primary biliary cirhosis was conducted and the course of the disease was followed. In total, 111 patients with primary biliary cirrhosis were identified for the 10‐yr period 1973 to 1982 in the northern health region of Sweden. The mean annual incidence amounted to 13.3 per million and the point prevalence was 151 per million, which is the highest reported so far.
Raouf E. Nakhleh, Sarah J. Schwarzenberg, Joseph Bloomer, William Payne, Dale C. Snover – 1 March 1990 – Although prolonged survival after liver transplantation is now common, the condition of allografts after prolonged survival has not been widely discussed. We reviewed 86 biopsy samples from 38 patients. The samples were obtained between 366 and 1,622 days after transplant. Thirteen patients' biopsy samples were normal or showed minor changes. Six patients' samples showed rejection. Four patients, including two with rejection, demonstrated ischemic change.
Bengt Jeppsson – 1 March 1990 – A simple, inexpensive alternative method of blunt dissection for dividing liver parenchyma utilizing a suction knife is presented. The device, made from an ordinary suction tube, has been used successfully in six patients. Details of the device and method are discussed herein.
D. Montgomery Bissell, Scott L. Friedman, Jacquelyn J. Maher, F. Joseph Roll – 1 March 1990