A pilot study of ribavirin therapy for chronic hepatitis C

Adrian M. di Bisceglie, Michiko Shindo, Tse‐Ling Fong, Michael W. Fried, Mark G. Swain, Nora V. Bergasa, Constantine A. Axiotis, Jeanne G. Waggoner, Yoon Park, Jay H. Hoofnagle – 1 September 1992 – Interferon‐α therapy is of proven efficacy in chronic hepatitis C, but it is not universally effective and may be associated with intolerable side effects. Ribavirin is a nucleoside analog with a broad spectrum of antiviral action. We conducted an uncontrolled pilot study of ribavirin therapy in 13 patients with chronic hepatitis C.

In situ hybridization studies in hepatitis A infection

G. Michael Taylor, Robert D. Goldin, Peter Karayiannis, Howard C. Thomas – 1 September 1992 – An in situ hybridization method using radiolabeled oligonucleotide probes was developed to study primary sites of hepatitis A virus replication in an experimental animal model of infection. Hepatitis A genomic sequences were demonstrated in hepatocytes of four marmosets with acute hepatitis A by use of antisense probes. In two of these animals, staining was also found when a sense probe was used, which is consistent with active replication in the hepatocytes.

Inhibition of rat hepatic lipocyte activation in culture by interferon‐γ

Don C. Rockey, Jacquelyn J. Maher, William R. Jarnagin, Giulio Gabbiani, Scott L. Friedman – 1 September 1992 – Hepatic lipocytes (perisinusoidal, Ito cells) are the primary matrix‐producing cells in liver fibrosis. During liver injury they undergo activation, a process characterized by cell proliferation and increased fibrogenesis. We and others have established a culture model in which in vivo features of lipocyte activation can be mimicked by cells grown on plastic.

Ursodeoxycholic acid for treatment of primary sclerosing cholangitis: A placebo‐controlled trial

Ulrich Beuers, Ulrich Spengler, Wolfgang Kruis, ülker Aydemir, Baldur Wiebecke, Walter Heldwein, Marlene Weinzierl, Gerd R. Pape, Tilman Sauerbruch, Gustav Paumgartner – 1 September 1992 – The efficacy and safety of ursodeoxycholic acid for the treatment of primary sclerosing cholangitis were evaluated in a prospective, randomized, double‐blind, placebo‐controlled trial. Fourteen patients with primary sclerosing cholangitis documented by cholestatic serum enzyme pattern, liver histological appearance and endoscopic retrograde cholangiography were included in the trial.

Flow‐limited tracer oxygen distribution in the isolated perfused rat liver: Effects of temperature and hematocrit

Ibrahim Kassissia, Colin P. Rose, Carl A. Goresky, Andreas J. Schwab, Glen G. Bach, Suzette Guirguis – 1 September 1992 – We used the multiple‐indicator dilution technique to examine the kinetics of tracer oxygen distribution and uptake in the rat liver perfused in a nonrecirculating fashion with blood. 51Cr‐labeled 18O2‐saturated erythrocytes, labeled albumin, sucrose and water (the tracers for oxygen and vascular, interstitial and cellular references) were injected simultaneously into the portal vein.

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