Hiromu Kawahara, Monique Cadrin, George Perry, Lucila Autilio‐Gambetti, Sabine H. H. Swierenga, Janis Metuzals, Normand Marceau, Samuel W. French – 1 March 1990 – The role of cytokeratin filaments in the function of hepatocytes was investigated using a nickel‐treated hepatocyte in vitro model. Cytokeratin intermediate filaments were selectively dissociated from the cell cortex by nickel treatment. Cytokeratins and ubiquitin were observed using immunofluorescence and immunoelectrom microscopy.

J. Julian Lopez – 1 March 1990

Fabio Tinè, Luigi Pagliaro, Albert J. Czaja, J. Eileen Hay, Jorge Rakela – 1 March 1990

Rosemary Hickman, Cath Rose Innes – 1 March 1990 – A study was conducted comparing the effects of initial arterialization vs. initial portal revascularization in unstored warm ischemic (for 30 min) livers, livers stored for 4 hr at 0° C in Collins solution and livers rendered warm ischemic for 1 hr before removal and replacement as autografts. All livers that received initial arterialization showed uniform diffuse perfusion, whereas those with initial portal perfusion were patchy and well perfused only in the right lobe.

Jay N. Cohn – 1 March 1990 – In nine patients with decompensated alcoholic cirrhosis of the liver and impaired renal function the effect of 8‐ornithin vasopressin (ornipressin) on renal function and haemodynamic parameters was studied. Ornipressin was infused at a dose of 6 IU/h over a period of four hours. During ornipressin infusion an improvement of renal function was achieved as indicated by an increase of creatinine clearance (76 (15)%; p < 0.01), urine volume (108 (29)%; p < 0.05) and sodium excretion (168 (30)% p < 0.05).

Horace E. Walpole, William M. Lee, Thomas Walle, U. Kristina Walle, Michael J. Wilson, John W. Kennedy – 1 March 1990 – Isolated hepatocyte cultures have become a frequently used model system for investigating drug metabolism. Although rat and hamster hepatocytes are frequently used for this purpose, metabolism in these species differs in many respects from human metabolism. A species with a metabolism more closely resembling that of humans might be more useful.

Martin Adson – 1 March 1990 – Metastatic carcinoma to the liver is generally considered to be associated with a poor prognosis, with five year survival of only 20% to 30% after resection of solitary lesions. Ninety‐eight consecutive patients underwent the surgical removal of one to 13 metastatic lesions from the liver. A rising carcinoembryonic antigen level was considered an indication for reexploration. All gross tumor was removed in every patient; 66 had more than one metastasis.

Thomas R. Kelly, Clive V. Greenway, Wayne W. Lautt, Daniel Sitar – 1 March 1990

Steven B. Heymsfield, Masako Waki, John Reinus – 1 March 1990

S. de Rave, S. W. Schalm, E. Rolland Dickson, Patrica M. Grambsch – 1 March 1990