Rabbit hepatocytes in primary culture: Preparation, viability and use in studies of propranolol metabolism
Horace E. Walpole, William M. Lee, Thomas Walle, U. Kristina Walle, Michael J. Wilson, John W. Kennedy – 1 March 1990 – Isolated hepatocyte cultures have become a frequently used model system for investigating drug metabolism. Although rat and hamster hepatocytes are frequently used for this purpose, metabolism in these species differs in many respects from human metabolism. A species with a metabolism more closely resembling that of humans might be more useful.