Patricia M. Grambsch, E. Rolland Dickson, Marshall Kaplan, Gene Lesage, Thomas R. Fleming, Alice L. Langworthy – 1 November 1989 – The generalizability of the Mayo model for predicting survival in individual primary biliary cirrhosis patients without liver transplantation was tested and confirmed. The model was applied to a data base of patients from the New England Medical Center Hospitals (n = 141) and the Scott and White Clinic (n = 35) and found to predict their survival accurately.

Patrice A. Michaletz, Ludèk Cap, Elliot Alpert, Bernhard H. Lauterburg – 1 November 1989 – A breath test to assess hepatic mitochondrial function in vivo was evaluated in rats. Following the i.p. administration of [1‐14C]‐α‐ketoisocaproic acid, 14CO2 exhalation reached a peak within 10 to 20 min and then declined exponentially, with a half‐life of 14.3 min. Control animals exhaled 38.6% of the administered radioactivity within 1 hr.

Delawir Kahn, Qihua Zeng, Leonard Makowka, Noriko Murase, Yasuaki Nakajima, Patricia K. Eagon, Antonio Francavilla, Thomas E. Starzl, David H. van Thiel – 1 November 1989 – Mammalian liver is known to contain cytosolic receptors for both estrogens and androgens. Furthermore, certain mammalian hepatic functions are known to display a sexual dimorphism. However, in clinical liver transplantation, the sex of the donor is not taken into consideration in selection of the donor.

N. C. Nayak – 1 November 1989

Kunio Okuda, Hector Orozco, Guadalupe Garcia‐Tsao, Takeshi Takahashi – 1 November 1989

Timothy J. Hearn, Anton E. Coleman, James C. K. Lai, Owen W. Griffith, Arthur J. L. Cooper – 1 November 1989 – L‐Carnitine (16 mmoles per kg, injected intraperitoneally) is reported to protect mice against subsequent injection of ammonium acetate given at the unprotected LD100. The present studies in rats show a variable protective effect of L‐carnitine (16 mmoles per kg) administered 1 hr prior to an LD100 dose of ammonium acetate. Survival ranged from 100% to 35%.

Jens H. Henriksen – 1 November 1989 – Methionine enkephalin and catecholamines were measured in carefully collected plasma samples from 25 patients with cirrhosis and ascites, and 25 with cirrhosis without ascites, 15 disease and 15 healthy controls. Methionine enkephalin was invariably raised in the ascites group, the median value being 4.6–6.9 times that of the other three groups. Similarly, in the ascites group, median noradrenaline was increased 2.5–4.2 and median adrenaline 1.8–2.5 times that of the other groups.

Yohko K. Shimizu, Robert H. Purcell – 1 November 1989 – We previously described a cytoplasmic antigen, detected by monoclonal antibodies, in hepatocytes of chimpanzees experimentally infected with the parenterally transmitted form of non‐A, non‐B hepatitis virus or with the hepatitis delta virus. The expression of this antigen appears to be a host‐specified response to infection with these two hepatitis viruses but not with hepatitis A virus, hepatitis B virus or enterically transmitted non‐A, non‐B hepatitis virus.

Renee C. Lin, Lawrence Lumeng – 1 November 1989 – We have previously reported the detection of a 37 kD liver protein‐acetaldehyde adduct in rats fed alcohol chronically with the AIN'76 diet. It was surprising that only one liver protein‐acetaldehyde adduct was found. In this report, we have tried to detect additional protein‐acetaldehyde adducts by electroimmunotransblot with rabbit anti‐hemocyanin‐acetaldehyde adduct IgG and to further characterize the 37 kD liver protein‐acetaldehyde adduct.

Harold O. Conn, Owen Epstein – 1 November 1989 – In ninety families with at least one proven case of Wilson's disease, seen over 32 years, all close relatives were examined and “presymptomatic” disease was diagnosed in 30.11 had one or more abnormal physical signs when examined and 7 of these had Kayser Fleischer rings. In a further 10 patients the abnormalities of copper metabolism were so pronounced as to leave no doubt as to the diagnosis.