Peter Karayiannis, John Saldanha, John Monjardino, Robert Goldin, Janice Main, Shashi Luther, Mark Easton, Antonio Ponzetto, Howard C. Thomas – 1 November 1990 – To assess the role of immunization against hepatitis delta antigen in the prevention of hepatitis delta virus infection, woodchuck carriers of woodchuck hepatitis virus were immunized with a 64 amino acid portion of hepatitis delta antigen from its N‐terminal region. The protein was expressed in Escherichia coli and contained a major immunogenic epitope.

Ian R. Wanless, Powers Peterson, Asha Das, John K. Boitnott, G. William Moore, Vincent Bernier – 1 November 1990 – The pathogenesis of portal hypertension arising in patients with myeloproliferative disorders has been difficult to understand because liver biopsy findings often show minimal changes. It has been suggested that increased splenic blood flow, hepatic infiltration with hematopoietic cells or sinusoidal fibrosis may be important.

V. J. Desmet, Peter van Eyken, Raf Sciot – 1 November 1990 – Immunohistochemistry with monoclonal anti‐cytokeratin antibodies has revealed the presence of cytokeratin 19 in embryonic and early fetal hepatocytes. With the differentiation of bile ducts at about the 10th week, cytokeratin 19 disappears from liver cells but remains in bile duct cells. This marks an important step in the organogenesis of the liver.

Christian Müller, Christoph C. Zielinski – 1 November 1990 – We investigated lipopolysaccharide‐induced tumor necrosis factor production in vitro by peripheral blood monocytes from patients with various liver diseases.

Antonio Francavilla, Carmine Panella, Lorenzo Polimeno, Antonio Giangaspero, Vincenzo Mazzaferro, Chen‐En Pan, David H. Van Thiel, Thomas E. Starzl – 1 November 1990 – Thirteen patients who underwent 40% to 80% removal of their livers had blood samples drawn initially and daily on postoperative days 1 to 7. The enzyme marker of heightened polyamine metabolism, ornithine decarboxylase, and the indicator of DNA synthesis, thymidine kinase, were measured.

Józefa Wȩsierska‐Ga̧dek, Edward Penner, Eva Hitchman, Georg Sauermann – 1 November 1990 – Sera of patients with chronic hepatitis delta virus infection stained the nuclear periphery in indirect immunofluorescence. Using proteins of isolated nuclei, isolated nuclear matrices, the nuclear pore complexlamina fraction and purified lamins A and C as antigen source in immunoblotting experiments, nuclear lamin C was identified as the reactive antigen. Most sera tested (8 of 10) recognized nuclear lamin C exclusively, but not the nuclear lamins A and B.

Irmin Sternlieb – 1 November 1990

M. Sawkat Anwer – 1 November 1990 – The mechanism(s) and driving force(s) for hepatocellular uptake of the unconjugated bile acid cholate were investigated in isolated basolateral (sinusoidal) rat liver plasma membrane (blLPM) vesicles and in protein free liposomes. In blLPM vesicles both an inwardly directed Na+ gradient and a transmembrane pH difference (8.0 in/6.0 out) stimulated cholate uptake 2‐3‐fold above equilibrium uptake values (overshoot).

José V. Castell, Maria José Gómez‐lechón, Martina David, Ricardo Fabra, Ramón Trullenque, Peter C. Heinrich – 1 November 1990 – Human hepatocytes in primary culture were used as a model system to investigate the mechanism(s) involved in the induction of the acute‐phase response in human liver. Hepatocytes were incubated with increasing amounts of recombinant human interleukin1β;, recombinant interleukin‐6 and tumor necrosis factor‐α. Synthesis of C‐reactive protein was studied at the mRNA and protein levels.

Martin J. Smit, Anneke M. Duursma, Jan Koudstaal, Machiel J. Hardonk, Joop M. W. Bouma – 1 November 1990 – In previous experiments in rats, we have shown that the rapid plasma clearance of a number of clinically important enzymes is due to receptor‐mediated endocytosis by Kupffer cells and other resident macrophages. Others have shown that infection of mice with lactate dehydrogenase—elevating virus, a virus that proliferates in macrophages, leads to reduced plasma elimination of these enzymes. This paper integrates these two sets of experiments.