Spontaneous bacterial peritonitis in cirrhosis: Predictive factors of infection resolution and survival in patients treated with cefotaxime

Claudio Toledo, Joan‐Manuel Salmerón, Antoni Rimola, Miquel Navasa, Vicente Arroyo, Josep Llach, Angels Ginés, Pere Ginès, Joan Rodés – 1 February 1993 – Cefotaxime is the most commonly used antibiotic for initial therapy of spontaneous bacterial peritonitis in cirrhosis. However, since the introduction of cefotaxime no study has been performed to investigate factors influencing prognosis in cirrhotic patients with this type of infection.

Effects of propranolol on gastric mucosal perfusion in cirrhotic patients with portal hypertensive gastropathy

Julián Panés, Josep M. Bordas, Josep M. Piqué, Juan C. García‐pagán, Faust Feu, Josep Terés, Jaime Bosch, Joan Rodés – 1 February 1993 – This study investigated the effects of the short‐term administration of propranolol on gastric blood perfusion in cirrhotic patients with portal hypertensive gastropathy. Portal hypertensive gastropathy is a common cause of nonvariceal bleeding in cirrhosis, which is associated with increased gastric mucosal perfusion and is favorably influenced by propranolol therapy.

Induction of cytochrome P‐4502E1 in the human liver by ethanol is caused by a corresponding increase in encoding messenger RNA

Toru Takahashi, Jerome M. Lasker, Alan S. Rosman, Charles S. Lieber – 1 February 1993 – The propensity of centrilobular liver damage to develop in alcohol abusers after exposure to various hepatotoxins, including ethanol itself, has been linked to the induction by ethanol of P‐4502E1, a microsomal P‐450 enzyme that bioactivates these agents to reactive metabolites.

Renal vasoconstriction in cirrhosis evaluated by duplex doppler ultrasonography

David Sacerdoti, Massimo Bolognesi, Carlo Merkel, Paolo Angeli, Angelo Gatta – 1 February 1993 – Studies of renal perfusion when kidney function tests are still normal could be useful to understand the pathophysiology of functional kidney impairment in cirrhosis; currently, this requires invasive methodology. Duplex Doppler ultrasonography allows noninvasive evaluation of intrarenal arterial resistances.

Bile Acid Sulfonates Alter Cholesterol Gallstone Incidence in Hamsters

Bertram I. Cohen, Shigeo Miki, Erwin H. Mosbach, Nariman Ayyad, Richard J. Stenger, Takahiro Mikami, Michiko Yoshii, Kenji Kihira, Takahiko Hoshita – 1 January 1993 – The prevention of cholesterol gallstone formation by three bile acid analogs, sodium 3α,7α‐dihydroxy‐5β‐cholane‐24‐sulfonate, sodium 3α,7β‐dihydroxy‐5β‐cholane‐24‐sulfonate and sodium 3α, 6α‐dihydroxy‐5β‐cholane‐24‐sulfonate, was examined in a hamster model of cholesterol cholelithiasis. Sodium taurochenodeoxycholate, sodium tauroursodeoxycholate and sodium taurohyodeoxycholate were studied simultaneously for comparison.

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