Etienne Marc Sokal, Elizabeth Collette, Jean Paul Buts – 1 February 1993 – To determine the zonal distribution of alcohol dehydrogenase in normal and cirrhotic human livers, we measured activities of this enzyme by quantitative cytochemical analysis along the liver cell plate in liver specimens from 10 normal organ donors and from 7 children with extrahepatic biliary atresia cirrhosis.

Liliana Chemello, Daniela Cavalletto, Patrizia Pontisso, Flavia Bortolotti, Carlo Donada, Valter Donadon, Mario Frezza, Pietro Casarin, Alfredo Alberti – 1 February 1993 – Patients with hepatitis C virus infection may have circulating antibodies to various structural and nonstructural antigens of the virus.

Alain Dubois, Michel Dauzat, Christine Pignodel, Gilles Pomier‐Layrargues, Christiane Marty‐Double, François‐Michel Lopez, Charles Janbon – 1 February 1993 – The pathogenesis of portal hypertension in patients with lymphoproliferative and myeloproliferative disorders is not fully understood. We investigated 20 patients with myeloproliferative disease and 47 patients with lymphoproliferative disease.

Glynn Bolitho, Gert Engelbrecht, Zoe Lotz, Marilyn Tyler, Heather McLeod, Kaz Jaskiewicz, Rosemary Hickman – 1 February 1993 – Current knowledge of liver regeneration after reduced liver transplantation is limited. Warm ischemia is one component of the reduced liver transplantation procedure that could have an impact on the regenerative response.

Antoine Hadengue, Didier Lebrec, Richard Moreau, Philippe Sogni, François Durand, Christophe Gaudin, Jacques Bernuau, Jacques Belghiti, Brice Gayet, Serge Erlinger, Jean‐Pierre Benhamou – 1 February 1993 – Portal pressure and portal‐systemic collateral circulation after orthotopic liver transplantation have not been investigated. We studied systemic and splanchnic hemodynamics in 17 patients with cirrhosis before and 205 ± 146 days after orthotopic liver transplantation.

Daphna Fenyves, Louise Gariépy, Jean‐Pierre Villeneuve – 1 February 1993 – To delineate the factors responsible for impaired clearance in cirrhosis, we examined propranolol disposition in rats with carbon tetrachloride–induced cirrhosis and compared it with that in control animals, rats treated with chlorpromazine (an inhibitor of propranolol metabolism) and rats with acute liver injury. We measured the extraction ratio of propranolol by the isolated perfused liver and related it to estimates of propranolol drug‐metabolizing enzyme activity in homogenates of the same livers.

Hui‐Cheng Cheng, Chuen‐May Yang, Ming‐Shi Shiao – 1 February 1993 – Hepatic zonation of cholesterol and glycerolipid synthesis was investigated in regenerating rat livers 24 hr after partial hepatectomy. Tritiated acetate and [U‐14Clglycerol were injected into rats' peritoneal cavities for a short‐term labeling study. Periportal and perivenous hepatocytes were isolated by digitonin collagenase perfusion. Cholesterol synthesis was significantly higher in periportal hepatocytes of the sham‐operated livers (periportal/perivenous = 1.67; p < 0.05).

1 February 1993

Irwin M. Arias, Mingxin Che, Zenaida Gatmaitan, Cynthia Leveille, Toshirou Nishida, Marie St. Pierre – 1 February 1993

Shuichi Terasaki, Yasuni Nakanuma, Masakazu Yamazaki, Masashi Unoura – 1 February 1993 – Eosinophils and their secretory proteins are important in necroinflammatory processes. In this study we surveyed eosinophilic infiltration of the liver in 176 liver biopsy specimens from patients with primary biliary cirrhosis. A considerable number of eosinophils were found in the portal tracts in 51 of these specimens (29%), whereas this finding occurred in only 2 of 50 (4%) specimens from patients with viral chronic active hepatitis. Eosinophilic infiltration of the portal tracts was focal.