Toru Takahashi, Jerome M. Lasker, Alan S. Rosman, Charles S. Lieber – 1 February 1993 – The propensity of centrilobular liver damage to develop in alcohol abusers after exposure to various hepatotoxins, including ethanol itself, has been linked to the induction by ethanol of P‐4502E1, a microsomal P‐450 enzyme that bioactivates these agents to reactive metabolites.
Raymond S. Koff, Elihu M. Schimmel – 1 February 1993
1 February 1993
Julián Panés, Josep M. Bordas, Josep M. Piqué, Juan C. García‐pagán, Faust Feu, Josep Terés, Jaime Bosch, Joan Rodés – 1 February 1993 – This study investigated the effects of the short‐term administration of propranolol on gastric blood perfusion in cirrhotic patients with portal hypertensive gastropathy. Portal hypertensive gastropathy is a common cause of nonvariceal bleeding in cirrhosis, which is associated with increased gastric mucosal perfusion and is favorably influenced by propranolol therapy.
Bruce R. Davidson – 1 February 1993
Claudio Toledo, Joan‐Manuel Salmerón, Antoni Rimola, Miquel Navasa, Vicente Arroyo, Josep Llach, Angels Ginés, Pere Ginès, Joan Rodés – 1 February 1993 – Cefotaxime is the most commonly used antibiotic for initial therapy of spontaneous bacterial peritonitis in cirrhosis. However, since the introduction of cefotaxime no study has been performed to investigate factors influencing prognosis in cirrhotic patients with this type of infection.
David A. Brenner, Linda Veloz, Rudolf Jaenisch, Joseph M. Alcorn – 1 February 1993 – Cirrhosis is characterized by a marked increase in the deposition of type I collagen and in the expression of the type I collagen genes α1(I) and α2(I). Although α1(I) gene regulation has been extensively studied in cultured cells, these results may not be applicable to hepatic fibrogenesis in vivo.
1 February 1993
Lawrence Serfaty, Philippe Giral, Marie Hélène Elghouzzi, Anne Marie Jullien, Raoul Poupon – 1 February 1993 – Studies of blood donors positive for antibody to hepatitis C virus on enzyme‐linked immunosorbent assay are probably biased by the large number of false‐positive results.
Jacek Rozga, Frederick Williams, Man‐Soo Ro, Daniel F. Neuzil, Todd D. Giorgio, Gisela Backfisch, Albert D. Moscioni, Raymond Hakim, Achilles A. Demetriou – 1 February 1993 – We have developed a bioartificial liver support system utilizing hollow‐fiber bioreactor, plasmapheresis and microcarrier cell culture technologies. Liver cells were obtained through portal vein perfusion with ethylenediaminetetraacetate or ethylenediaminetetraacetate/collagenase.