Evaluation of structural change in diffuse liver disease with frequency domain analysis of ultrasound

Kunio Suzuki, Norio Hayashi, Yutaka Sasaki, Michikazu Kono, Akinori Kasahara, Yutaka Imai, Hideyuki Fusamoto, Takenobu Kamada – 1 June 1993 – To evaluate structural changes in diffuse liver disease, frequency domain analysis was applied to ultrasonic signals from the liver. We assumed that liver tissue is a collection of semiregularly arrayed small scatterers of ultrasound. We applied cepstral analysis to the ultrasonic waveforms and evaluated the periodicity of scalloping of the power spectrum caused by an interference effect among liver scatterers of a given spacing.

Incidence of adverse reactions to cyclosporine after liver transplantation is predicted by the first blood level

Daniel Azoulay, Antoinette Lemoine, Ashley Dennison, Jean Michel Gries, Isabelle Dolizy, Denis Castaing, Philippe Beaune, Henri Bismuth – 1 June 1993 – Despite the availability of whole‐blood cyclosporine assays, the different responses of individual patients to its administration after transplantation continue to pose clinical problems, particularly with respect to toxicity. Fifty‐seven recipients of first orthotopic liver transplants were studied between January 1992 and July 1992.

Quantitative analysis of antibodies to hepatitis C virus during interferon‐α therapy

Nobukazu Yuki, Norio Hayashi, Hideki Hagiwara, Tetsuo Takehara, Kazuhiro Katayama, Akinori Kasahara, Hideyuki Fusamoto, Takenobu Kamada – 1 June 1993 – We quantified IgG antibodies to structural (core) and nonstructural (C100‐3) hepatitis C virus proteins in 42 patients with chronic hepatitis C treated with a 6‐mo course of interferon‐α Sera were drawn before and at the end of therapy and also 6 mo after therapy withdrawal; they were stored for later analysis of antibodies and serum hepatitis C virus RNA.

Magnetic resonance imaging and different levels of Iron overload in chronic liver disease

Emilio Rocchi, Marco Cassanelli, Athos Borghi, Franco Paolillo, Marcello Pradelli, Giovanna Casalgrandi, Aldo Burani, Ennio Gallo – 1 June 1993 – The need for accurate and noninvasive evaluation of liver iron stores prompted us to evaluate the reliability of high‐field magnetic resonance imaging equipment in liver patients with low or moderate siderosis, given the poor results obtained using systems operating at low field strength in such cases.

Diagnosis and follow‐up of small hepatocellular carcinoma with selective intraarterial digital subtraction angiography

Kenji Ikeda, Satoshi Saitoh, Isao Koida, Akihito Tsubota, Yasuji Arase, Kazuaki Chayama, Hiromitsu Kumada – 1 June 1993 – To clarify the angiographic features of small hepatocellular carcinoma, we performed digital subtraction angiography in 91 patients with hepatocellular carcinomas of 2 cm or less. Repeated digital subtraction angiography studies were performed in 25 patients whose first angiograms showed no tumor staining. Digital subtraction angiography showed hypervascular tumor staining in only 51 patients (56.0%).

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