Antonio González, Juan I. Esteban, Pedro Madoz, Luis Viladomiu, Juan Genesca, Eduardo Muñiz, Jaime Enríquez, Xavier Torras, José M. Hernández, Josep Quer, Xavier Vidal, Harvey J. Alter, James W. Shih, Rafael Esteban, Jaime Guardia – 1 August 1995 – Routine screening of blood donors for anti‐hepatitis C virus (HCV) has been implemented in most developed countries. However, the independent efficacy of such screening has not been established in a controlled, prospective study.

Stephan Krähenbühl, Christine Talos, Bernhard H. Lauterburg, Jürg Reichen – 1 August 1995 – Lipid peroxidation and antioxidative mechanisms were investigated in liver mitochondria from bile duct ligated rats (BDL rats) and correlated with the activity of enzyme complexes of the electron transport chain. In comparison to pair‐fed control rats, BDL rats had increased concentrations of thiobarbituric acid reacting substances (TBARS) per gram of liver and per milligram of mitochondrial protein 3, 7, 14, and 28 days after surgery.

Jane M. Geders, Salima Haque, Raymond J. Tesi, Michael A. Gerber, Anna S. F. Lok – 1 August 1995

1 August 1995

Tomas Sveger, Sten Eriksson – 1 August 1995 – Of 200,000 Swedish infants screened for α1‐antitrypsin deficiency (α1ATD), 184 (127 PiZ, 2 PiZ–, 54 PiSZ, and 1 PiS–) children have been followed prospectively, of whom 1 PiSZ and 5 PiZ children died in early childhood. We now report clinical and biochemical signs of liver disease in adolescence and the prognosis of neonatal liver disease up to the age of 18 years. The α1ATD subjects were offered a clinical checkup and liver tests at 16 and 18 years of age, 150 of 178 α1ATD subjects undergoing checkups at age 16 and 166 at age 18.

Ramon Estruch, Joaquim Fernández‐Solá, Emilio Sacanella, Carles Paré, Emanuel Rubin, Alvaro Urbano‐Márquez – 1 August 1995 – Based on anecdotal impressions, there is a common clinical perception that alcoholics with liver disease do not develop cardiomyopathy and that those with alcohol‐induced cardiac disease are spared cirrhosis.

Paul A. Cahill, Cory Foster, Eileen M. Redmond, Cindy Gingalewski, Yuping Wu, James V. Sitzmann – 1 August 1995 – Portal hypertension (PHT) is characterized by splanchnic hyperemia caused by a reduction in mesenteric vascular resistance. Mediators of this hyperemia include nitric oxide (NO). This is based on several reports indicating a marked splanchnic hyporesponsiveness in PHT to vasoconstrictor stimuli, both in vitro and in vivo, and a subsequent reversal using specific inhibitors of NO synthase (NOS).

Loren Laine – 1 August 1995

Masafumi Naito, Norio Hayashi, Toyoki Moribe, Hideki Hagiwara, Eiji Mita, Yoshiyuki Kanazawa, Akinori Kasahara, Hideyuki Fusamoto, Takenobu Kamada – 1 August 1995 – Hepatitis C virus (HCV) has been reported to conform to a quasispecies nature, which is most evident in hypervariable regions of the putative envelope 2 domain. The aim of this study was to determine the relationship between the nucleotide complexity and diversity of hypervariable region 1 and various stages of the carrier states.

Anne‐Marie Steffan, Carlos Augusto Pereira, Annick Bingen, Michele Valle, Jean‐Pierre Martin, Françoise Koehren, Cathy Royer, Jean‐Louis Gendrault, André Kirn – 1 August 1995 – Fenestrations of hepatic endothelial cells play an active role as a sieving barrier allowing extensive exchange between the blood and liver parenchyma. Alteraction of these structures may be induced in the course of various pathological events and provoke important perturbations of liver function.