Effect of orthotopic liver transplantation on bone mineral content and serum vitamin D metabolites in infants and children with chronic cholestasis

Eric A. Argao, William F. Balistreri, Bruce W. Hollis, Frederick C. Ryckman, James E. Heubi – 1 September 1994 – Almost all infants and children with chronic cholestasis have osteopenia. We evaluated the effect of orthotopic liver transplantation on bone mineral content and serum 25(OH)‐vitamin D–[25(OH)D]–of nine infants and children (five girls; age, 6 to 21 mo at the time of orthotopic liver transplantation) with end‐stage liver disease resulting from chronic cholestasis.

Effects of hemopexin on heme‐mediated repression of 5‐aminolevulinate synthase and induction of heme oxygenase in cultured hepatocytes

Peter R. Sinclair, William J. Bement, John F. Healey, Nadia Gorman, Jacqueline F. Sinclair, Herbert L. Bonkovsky, Heng H. Liem, Ursula Muller‐Eberhard – 1 September 1994 – The serum protein hemopexin is considered to have a major role in the mechanism of the uptake of heme by hepatocytes by means of a heme‐hemopexin receptor.

Detection and distribution of hepatitis C—specific antigens in naturally infected liver

Keril Blight, Richard R. Lesniewski, Justin T. Labrooy, Eric J. Gowans – 1 September 1994 – Hepatitis C virus antigen expression was examined using peptide antibodies in liver tissue taken at biopsy from four chronic carriers of hepatitis C virus. Hepatitis C virus antigens E2/NS1, NS3, NS4 and NS5 were widespread in unfixed frozen liver sections and were present as distinct granules or foci within the cytoplasm of hepatocytes and in infiltrating lymphocytes in portal tracts.

Appearance of sinusoidal inclusion‐containing endothelia cells in liver disease

Shinichi Iwamura, Hideaki Enzan, Toshiji Saibara, Saburo Onishi, Yasutake Yamamoto – 1 September 1994 – Sinusoidal “inclusion‐containing endothelial cells” were studied histopathologically and immunohistochemically in various liver diseases, and their clinical importance was investigated. A total of 498 needle liver biopsies were examined. Endothelial inclusions inside the cells were recognized as eosinophilic granules in hematoxylin‐eosin‐stained sections. Electron microscopy showed that these inclusions corresponded to round cytoplasmic dense bodies with a single limiting membrane.

Putrescine as a comitogen of epidermal growth factor in rat liver growth

Sumiko Nagoshi, Kenji Fujiwara – 1 September 1994 – Putrescine can stimulate regeneration of the remnant liver after partial hepatectomy in rats when exogenously administered, but its mitogenic action has not been shown in cultured hepatocytes. To find its action site(s) in the regulation of hepatocyte proliferation, we examined its effect on hepatocyte DNA synthesis in relation to mitogenic action of epidermal growth factor in vitro and in vivo.

The nature of complications following liver biopsy in transplant patients with Roux‐en‐Y choledochojejunostomy

Joseph S. Galati, Howard P. Monsour, Jeremiah P. Donovan, Rowen K. Zetterman, Daniel F. Schafer, Alan N. Langnas, Byers W. Shaw, Michael F. Sorrell – 1 September 1994 – Liver biopsy is an important diagnostic tool in the management of patients following orthotopic liver transplant. We evaluated complications following percutaneous liver biopsy in a group of liver transplant patients who had Roux‐en‐Y choledochojejunostomies fashioned as part of their biliary reconstruction during liver transplantation.

Predictive factors of early postoperative graft function in human liver transplantation

F. Xavier González, Antoni Rimola, Luis Grande, Maria Antolin, Juan C. Garcia‐Valdecasas, Jose Fuster, Antonio M. Lacy, Esteban Cugat, Jose Visa, Joan Rodés – 1 September 1994 – To identify factors predictive of early postoperative graft function, we analyzed 54 variables—including easily available clinical and laboratory data prospectively obtained from organ donors, transplant recipients and surgical procedures in 168 consecutive liver transplantations.

Outcome of liver transplantation in patients with hemochromatosis

Frank J. Farrell, Marie Nguyen, Susan Woodley, Joanne C. Imperial, Richard Garcia‐Kennedy, Kevin Man, Carlos O. Esquivel, Emmet B. Keeffe – 1 August 1994 – Recent preliminary reports suggest a poor outcome of orthotopic liver transplantation for patients with hemochromatosis. We analyzed an institutional experience with orthotopic liver transplantation for hemochromatosis, focusing on factors contributing to increased morbidity and mortality. Between March 1988 and October 1992, nine of 249 adults (3.6%) undergoing orthotopic liver transplantation had hemochromatosis.

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