The role of inflammatory mediators on hepatitis B virus surface expression in a transgenic mouse model

1 September 1994 – We have recently reported that administration of recombinant tumor necrosis factor‐alpha to hepatitis B virus transgenic mice reduces the hepatic steadystate content of HBV‐specific mRNA by up to 80% in the absence of liver cell injury. In the current study, we analyzed the regulatory effects of several other inflammatory cytokines in the same transgenic model system. Hepatic HBV mRNA content was reduced by up to 90% following administration of a single noncytopathic dose (100,000U) of interleukin‐2.

Posttranslational events involved in griseofulvin‐induced keratin cytoskeleton alterations

Hermann Salmhofer, Ingrid Rainer, Kurt Zatloukal, Helmut Denk – 1 September 1994 – Alcoholic hepatitis is a disease associated with profound alterations of the hepatocytic intermediate filament cytoskeleton. Similar cytoskeletal alterations can be induced in mice with prolonged feeding of the fungistatic drug griseofulvin. Murine hepatocytic intermediate filaments are composed of equimolar amounts of keratin polypeptides A (type II) and D (type I).

Papaverine inhibits bile acid excretion in isolated perfused rat liver

Tomoyuki Kumai, Makoto Hoshino, Tomihiro Hayakawa, Katsuyoshi Higashi – 1 September 1994 – We investigated the effects of papaverine on bile acid excretion into bile in the presence of infusions of taurocholic acid, tauroursodeoxycholic acid, taurochenodeoxycholic acid and taurodehydrocholic acid in a single‐pass, isolated perfused rat liver model.

Immunoglobulins and α1‐acid glycoprotein do not contribute to the cholesterol crystallization—promoting effect of concanavalin a—binding biliary protein

Marianne A. C., De Bruijn, Kam S. Mok, Tiny Out, Guido N. J. Tytgat, Albert K. Groen – 1 September 1994 – Human bile contains cholesterol crystallization—stimulating proteins that can be isolated by concanavalin A—Sepharose chromatography. In the past few years an increasing number of different pronucleating proteins have been identified in the concanavalin A—binding fraction. In this study we attempted to estimate the relative contribution of a number of these proteins to total concanavalin A—binding pronucleating activity.

The eosinophil as an effector cell of the immune response during hepatic allograft rejection

Piet C. De Groen, Gail M. Kephart, Gerald J. Gleich, Jurgen Ludwig – 1 September 1994 – Objective: To evaluate the role of the eosinophil granulocyte during hepatic allograft rejection. Design: (a) A retrospective case‐control study and (b) a prospective study of consecutive liver transplant recipients. Patients: In the retrospective study, eight patients with severe rejection in the first month after liver transplantation were compared with six patients without rejection.

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