Lukas Kenner, Yosuf El‐Shabrawi, Heinz Hutter, Michael Forstner, Kurt Zatloukal, Gerald Hoefler, Karl‐Heinz Preisegger, Robert Kurzbauer, Helmut Denk – 1 October 1994 – Tau protein is a member of the family of microtubule‐associated proteins, which support microtubule polymerization and stability. Under pathological conditions, tau is a major constituent of neurofibrillary tangles in nerve cells of patients with Alzheimer's disease.

Christoph Elsing, Hans Sägesser, JÜRg Reichen – 1 October 1994 – The aim of the investigation was to explore whether ursodeoxycholate, a tertiary bile acid with potential for treatment of chronic cholestasis in cirrhotic liver disease, has the same physiological effects in cirrhotic as in normal rats. Furthermore, we wanted to investigate whether ductular proliferation, as it occurred in this situation, increases the bicarbonate stimulatory effect of ursodeoxycholate.

Shotaro Sakisaka, Masaru Harada, Kazuhisa Gondo, Masao Yoshitake, Kyuichi Tanikawa – 1 October 1994 – The transcytotic vesicular pathway in isolated rat hepatocyte couplets was investigated using horseradish peroxidase. Ten to 20 min after horseradish peroxidase labeling, vesicles and tubules containing horseradish peroxidase were observed to be predominantly around the bile canaliculi.

Sherry S. Ansher, Walter Thompson – 1 October 1994 – Administration of whole‐cell diphtheria and tetanus toxoids and pertussis vaccine adsorbed (DTP vaccine) caused marked depression in the expression of mRNA for isozymes of cytochrome P‐450 in the livers of endotoxin‐responsive and nonresponsive mice. The levels of expression of mRNA for a polycyclic aromatic hydrocarbon–inducible (CYP 1A2) and an ethanol‐inducible (CYP2E1) form of P‐450 were reduced by 70% to 80% 8 to 12 hr after vaccination or Bordetella pertussis endotoxin administration.

Masahito Uemura, Ulrike Buchholz, Hideyuki Kojima, Andrea Keppler, Peter Hafkemeyer, Hiroshi Fukui, Tadasu Tsujii, Dietrich Keppler – 1 October 1994 – The significance of cysteinyl leukotrienes was investigated in patients with liver diseases by measurements of leukotriene E4 and N‐acetyl‐leukotriene E4 in urine.

Albert D. Min – 1 October 1994

Brian G. Harbrecht, Mauricio Di Silvio, A. J. Demetris, Richard L. Simmons, Timothy R. Billiar – 1 October 1994 – Tumor necrosis factor‐alpha is a principal mediator of the pathophysiological effects of endotoxemia and endotoxin shock. Tumor necrosis factor‐α also contributes to the stimulation of nitric oxide synthesis by the induction of the enzyme nitric oxide synthase in a variety of tissues.

Michelle J. Bingham, Harry J. McArdle – 1 October 1994 – We studied copper uptake from copper dihistidine complexes by plasma membrane vesicles isolated from rat liver and compared the data with those for uptake under the same conditions by hepatocytes cultured from rat liver to determine whether membrane vesicles can be used to study copper uptake. Marker enzyme analysis showed a 28‐fold increase in 5′‐nucleotidase activity, a slight increase in endoplasmic reticulum and no contamination with mitochondrial membranes.

Sanghoon Cha, Patrick S. C. Leung, Ross L. Coppel, Judy Van De Water, Aftab A. Ansari, M. Eric Gershwin – 1 September 1994 – The polyclonal nature of antimitochondrial autoantibodies and the limited success of generating human monoclonal antibodies have made analysis of fine specificity and antibody heterogeneity difficult to define. The major autoantigen of primary biliary cirrhosis is the E2 component of the pyruvate dehydrogenase pathway (PDC‐E2).

Cornelis J. F. Van Noorden, Ilse M. C. Vogels, Jan James – 1 September 1994 – To evaluate changes in metabolic heterogeneity in rat liver lobules after partial hepatectomy, we measured parameters of carbohydrate and lipid metabolism cytophotometrically in periportal and pericentral zones of livers of mature female and male rats. Glycogen content was shown to be always higher in pericentral zones than in periportal zones.