William J. Wall – 1 September 1995

Dirk De Craemer, Marina Pauwels, Christiane Van den Branden – 1 September 1995 – We investigated the hepatocellular peroxisomes in 27 patients with steatosis of the liver by means of catalase cytochemistry, light and electron microscopic study, and morphometry. Seven normal human livers were used as controls. In our patients, fatty liver was mainly associated with alcohol abuse or obesity. Indications for a slight decrease in catalase activity and for a proliferation were found by visual evaluation of the peroxisomes.

Fabio Marra, Giuseppe Grandaliano, Anthony J. Valente, Hanna E. Abboud – 1 September 1995 – Liver fat‐storing cells (FSC) proliferate and secrete extracellular matrix in experimental models of liver injury. In this study, we determined if thrombin, a serine protease produced during acute and chronic tissue injury, modulates the functions of FSC. Thrombin stimulated DNA synthesis and proliferation of FSC, as assessed by [3H]‐thymidine incorporation assay and measurement of cell number, respectively.

Sylvie Blazejewski, Anne‐Marie Preaux, Ariane Mallat, Isabelle Brocheriou, Philippe Mavier, Daniel Dhumeaux, Daniel Hartmann, Detlef Schuppan, Jean Rosenbaum – 1 September 1995 – During human fibrogenesis, myofibroblastlike cells proliferate and are the main source of fibrosis components. We have used cultured myofibroblastlike cells obtained by outgrowth from explants of human liver to study the expression of extracellular matrix (ECM) components and matrix‐metalloproteinase‐2 (MMP‐2). These cells contained types I, III, IV, and V procollagen messenger RNAs (mRNAs).

Hamid R. Amouzadeh, Lance R. Pohl – 1 September 1995 – In this study we have investigated the mechanism of the processing of trifluoroacetylated liver microsomal protein antigens associated with halothane hepatitis to learn how the immune system might come in contact with these proteins to form antibodies directed against them. Rats were treated with halothane and parenchymal (PC) and non‐parenchymal cells (NPC) were isolated 16 hours later.

Mario Guslandi, Alberto Tittobello, Masayuki Ohta, Makoto Hashizume, Keizo Sugimachi – 1 September 1995

Toshiji Saibara, Seiji Kawasaki – 1 September 1995

Bruno Turlin, Gabriella I. Slapak, Karen M. Hayllar, Nigel Heaton, Roger Williams, Bernard Portmann – 1 September 1995 – Centrilobular necrosis (CLN) is a histological finding often encountered after orthotopic liver transplantation, but its pathogenesis is still unknown. In this study, the significance of CLN was assessed in a series of 227 consecutive liver transplantations performed between January 1989, and December 1991. Seventy‐one patients (30.9%) showed CLN on at least one biopsy result, which were obtained because of an increase of aspartate aminotransferase activity.

Kenneth J. Hardy, Somsit Tancheroen, Arthur Shulkes – 1 September 1995 – The aim of the study was to determine if pretreatment with misoprostol (a prostaglandin analogue) or nifedipine (a calcium antagonist), known protectants of the whole liver, would ameliorate the ischemia‐reperfusion injury (IRI) of resected liver associated with vascular occlusion.

Burton Combes, Robert L. Carithers, Willis C. Maddrey, Danyu Lin, Mary F. McDonald, Donald E. Wheeler, Edwin H. Eigenbrodt, Santiago J. Muñoz, Raphael Rubin, Guadalupe Garcia‐Tsao, Gregory F. Bonner, Alexander B. West, James L. Boyer, Velimir A. Luketic, Mitchell L. Shiffman, A. Scott Mills, Marion G. Peters, Heather M. White, Rowen K. Zetterman, Stephen S. Rossi, Alan F. Hofmann, Rodney S. Markin – 1 September 1995 – One hundred fifty‐one patients with primary biliary cirrhosis (PBC) grouped into four strata based on entry serum bilirubin (<2 mg/dL vs.