Shinichi Kiso, Sumio Kawata, Shinji Tamura, Nobuyuki Ito, Kenji Takaishi, Yasuhiro Shirai, Hirofumi Tsushima, Yuji Matsuzawa – 1 November 1994 – Cell growth appears to be controlled by positive and negative cell growth regulation. Little is known about the growth regulation of hepatocytes in the cirrhotic liver. Clarifying the responses of hepatocytes obtained from cirrhotic liver to various growth factors and growth inhibitory factors might aid understanding of alterations in growth regulation of the hepatocytes in the cirrhotic liver.

Andrés C. Inglés, Dallas J. Legare, W. Wayne Lautt – 1 November 1994 – A model of prehepatic chronic portal hypertension in cats was used to determine portacaval shunt responses to infused norepinephrine and to possible transmitter overflow into portal blood from nerves supplying the gut. Responses are compared using a new index of contractility. Four weeks after application of a slowly constricting occluder, the portal vein was completely occluded and acute experiments were carried out under pentobarbital anesthesia.

Masao Honda, Shuichi Kaneko, Akito Sakai, Masashi Unoura, Seishi Murakami, Kenichi Kobayashi – 1 November 1994 – We examined the quasispecies of the hepatitis C virus genome in 28 patients with liver disease of varying severity.

Hiroaki Okamoto, Shunji Mishiro, Hajime Tokita, Fumio Tsuda, Yuzo Miyakawa, Makoto Mayumi – 1 November 1994 – Three chimpanzees persistently infected with hepatitis C virus of genotype II/1b were challenged with hepatitis C virus of genotype III/2a and 6 wk later with hepatitis C virus of genotype I/1a. They were tested for titers of total and genotype‐specific hepatitis C virus RNA, as well as for serum transaminase levels, until 52 wk after the first challenge.

Charles M. Noyer, Howard J. Worman – 1 November 1994

Jon W. Gordon – 1 November 1994

Shuichi Hanada, Takaji Wakita, Hiroshi Takahashi – 1 November 1994 – Fusion of BERH‐2 rat hepatocellular carcinoma cells with activated B cells produced hybrid cells that lost their tumorigenicity and became immunogenic. Syngeneic rats injected with BERH‐2‐B hybrid cells became resistant to challenge with parental BERH‐2 cells, and rats with established BERH‐2 hepatomas were cured by subsequent injection of BERH‐2‐B cells. Both CD4 and CD8+ cells were essential for the induction of protective immunity; however, only CD8+ cells were required for the eradication of BERH‐2 tumors.

William J. Parks – 1 November 1994

Jurgen Ludwig, Charles B. Rosen, Keith D. Lindor, John H. Helzberg, Kenneth R. Watson – 1 November 1994

Satoshi Ishiguro, Shigeki Arii, Kazunobu Monden, Yukito Adachi, Naomi Funaki, Hiroaki Higashitsuji, Shin‐Ichi Fujita, Masaharu Furutani, Masahiro Mise, Tadahiro Kitao, Toshio Nakamura, Fumitaka Ushikubi, Ken‐Ichi Nakamura, Shuh Narumiya, Katsuhiko Enomoto, Tousei Ohmura, Michio Mori, Masayuki Imamura – 1 November 1994 – The presence of the thromboxane A2 receptor in sinusoidal endothelial cells was investigated and its pathogenic role in endotoxin‐induced liver injury examined. The receptor was measured with a binding assay using a specific thromboxane A2 receptor antagonist, [3H]S‐145.