Cytokine patterns and cytotoxic mediators in primary biliary cirrhosis

Olivia M. Martinez, Janeth C. Villanueva, M. Eric Gershwin, Sheri M. Krams – 1 January 1995 – Primary biliary cirrhosis (PBC) is an autoimmune disease of the liver with unknown etiology. Autoreactive T lymphocytes that infiltrate the liver may play a major role in the bile duct damage that accompanies the disease. We hypothesized that cytokines produced by T lymphocytes and other cells are central to the disease process.

Bone marrow augmentation in solid organ transplantation–any conclusions?

John J. Fung – 1 January 1995 – Donor‐specific bone marrow infusion after organ grafting can induce tolerance in animals. In this randomized, controlled study we show it has no benefit in patients undergoing liver transplantation. Of 25 patients, 9 received bone marrow 5 days after a 10 day course of antithymocyte globulin. Immunosuppression was maintained with cyclosporin only. An average of 3·0 rejection episodes per patient was seen in the bone marrow group compared to 3·1 in the controls.

Transforming growth factor‐β1 regulates platelet‐derived growth factor receptor β subunit in human liver fat‐storing cells

Massimo Pinzani, Alessandra Gentilini, Alessandra Caligiuri, Raffaella De Franco, Giulia Pellegrini, Stefano Milani, Fabio Marra, Paolo Gentilini – 1 January 1995 – Activated liver fat‐storing cells (FSC) are known to play a key role in the development of liver fibrosis. An important element in FSC activation process is the increased expression of receptors for platelet‐derived growth factor (PDGF), a potent mitogen for FSC.

Acute cellular rejection after liver transplantation: Variability, morbidity, and mortality

Laurel R. Fisher, Keith S. Henley, Michael R. Lucey – 1 January 1995 – Acute cellular rejection of the allograft is a potentially serious complication after liver transplantation, yet its true incidence is unknown. We therefore investigated the frequency of acute cellular rejection reported by transplant centers and its impact on morbidity and mortality. Morbidity was defined as duration of hospitalization. Of 200 articles screened, 18 were selected for inclusion in the study database, in which there was a total of 1,437 patients who received transplants.

Early cellular rejection after orthotopic liver transplantation correlates with low concentrations of FK506 in hepatic tissue

William J. Sandborn, George M. Lawson, Timothy J. Cody, Michael K. Porayko, J. Eileen Hay, Gregory J. Gores, Jeffery L. Steers, Ruud A. F. Krom, Russell H. Wiesner – 1 January 1995 – We have previously reported that low hepatic tissue cyclosporine levels correlate with early cellular rejectionafter liver transplantation. The aim of this study is to determine whether there is a similar relationship in patients treated with FK506.

Subscribe to