Daniel Alvarez, Diego Golombek, Patricia Lopez, Marcelo De Las Heras, Luis Viola, Susana Sanchez, Miguel Kolker, Ricardo Mastai – 1 November 1994 – A close temporal relationship between higher levels of portal pressure during the night and the peak incidence of acute variceal bleeding has recently been demonstrated in patients with cirrhosis. Because hemodynamic changes may have a role in triggering this hemorrhagic episode, we measured systemic and portal hemodynamic parameters at 4‐hr intervals for 24 hr in 12 cirrhotic patients.

Francjan J. Van Spronsen, Yolande Thomasse, G. Peter A. Smit, James V. Leonard, Peter T. Clayton, Vaclav Fidler, Ruud Berger, Hugo S. A. Heymans – 1 November 1994 – Hereditary tyrosinemia type I (McKusick 27670) is a heterogeneous disease with poor prognosis, yet there are few reports of the long‐term prognosis. It is therefore difficult to decide on the treatment for individual patients. We have conducted an international survey of patients with tyrosinemia type I and examined the probability of survival on dietary treatment and the causes of death in 108 patients with tyrosinemia type I.

Julio Martín, Juan A. Quiroga, Orencio Bosch, Vicente Carreño – 1 November 1994 – Recombinant human granulocyte‐macrophage colony‐stimulating factor therapy significantly reduces serum hepatitis B virus DNA levels, associated with increased 2′, 5′‐oligoadenylate synthetase activity in cultured mononuclear cells of patients with chronic hepatitis B.

1 November 1994

Hideaki Suzuki, Shinsuke Iyomasa, Yuji Nimura, Shonen Yoshida – 1 November 1994 – We previously showed that hepatic cells proliferate in obstructive jaundice alone without partial hepatectomy and found that external biliary drainage for obstructive jaundice markedly suppresses liver regeneration after partial hepatectomy. In this study, we produced a model system for internal biliary drainage in which bile was drained into the stomach of rat fed a liquid diet.

Shinichi Kiso, Sumio Kawata, Shinji Tamura, Nobuyuki Ito, Kenji Takaishi, Yasuhiro Shirai, Hirofumi Tsushima, Yuji Matsuzawa – 1 November 1994 – Cell growth appears to be controlled by positive and negative cell growth regulation. Little is known about the growth regulation of hepatocytes in the cirrhotic liver. Clarifying the responses of hepatocytes obtained from cirrhotic liver to various growth factors and growth inhibitory factors might aid understanding of alterations in growth regulation of the hepatocytes in the cirrhotic liver.

Andrés C. Inglés, Dallas J. Legare, W. Wayne Lautt – 1 November 1994 – A model of prehepatic chronic portal hypertension in cats was used to determine portacaval shunt responses to infused norepinephrine and to possible transmitter overflow into portal blood from nerves supplying the gut. Responses are compared using a new index of contractility. Four weeks after application of a slowly constricting occluder, the portal vein was completely occluded and acute experiments were carried out under pentobarbital anesthesia.

Masao Honda, Shuichi Kaneko, Akito Sakai, Masashi Unoura, Seishi Murakami, Kenichi Kobayashi – 1 November 1994 – We examined the quasispecies of the hepatitis C virus genome in 28 patients with liver disease of varying severity.

Hiroaki Okamoto, Shunji Mishiro, Hajime Tokita, Fumio Tsuda, Yuzo Miyakawa, Makoto Mayumi – 1 November 1994 – Three chimpanzees persistently infected with hepatitis C virus of genotype II/1b were challenged with hepatitis C virus of genotype III/2a and 6 wk later with hepatitis C virus of genotype I/1a. They were tested for titers of total and genotype‐specific hepatitis C virus RNA, as well as for serum transaminase levels, until 52 wk after the first challenge.

Charles M. Noyer, Howard J. Worman – 1 November 1994