Pere Ginès, Xiaomei Li, Jeffrey L. Zamarripa, Susan E. S. Brown, Eric D. Wieder, Toshikazu Nakamura, Phillip S. Guzelian, Robert W. Schrier, Lynn E. Heasley, Raphael A. Nemenoff – 1 October 1995 – The response of rat hepatocytes to hormones and growth factors has been extensively studied with respect to phospholipase regulation and calcium mobilization. However, the mitogen‐activated protein (MAP) kinase cascade which integrates signals from a wide variety of extracellular stimuli has not been examined in these cells.

Cyrille Féray, Didier Samuel, Michèle Gigou, Valérie Paradis, Marie Francoise David, Catherine Lemonnier, Michel Reynès, Henri Bismuth – 1 October 1995 – The aim of this open trial was to assess the efficacy and the safety of interferon (IFN) alfa therapy in liver transplant recipients with chronic active hepatitis caused by hepatitis C virus. In July 1991, among 447 liver recipients regularly observed at our institution, 46 had developed HCV‐related chronic active hepatitis defined by piece meal necrosis.

Matthew Golding, Catherine E. Sarraf, El‐Nasir Lalani, T. V. Anilkumar, Robert J. Edwards, Peter Nagy, Snorri S. Thorgemsson, Malcolm R. Alison – 1 October 1995 – When hepatocyte regeneration after a two‐thirds partial hepatectomy (PH) in rats is blocked by oral gavage of acetylaminofluorene, a proliferation of ductular cells ensues that results in a profusion of neoductules radiating from each portal tract.

Jordi Muntané‐Relat, Jean‐Claude Ourlin, Jacques Domergue, Patrick Maurel – 1 October 1995 – We have investigated the effect of cytokines, including interleukin‐6 (Il‐6), interleukin‐1α (Il‐1α), and tumor necrosis factor‐alpha (TNF‐α), on the inducible expression of cytochrome P450s (CYP) CYP1A1, CYP1A2, and CYP3A4 in human hepatocytes in primary culture. The ability of these cultures to mimic the acute phase response when stimulated with cytokines was evaluated using immunoblotting to measure the production of albumin, ferritin, fibrinogen, and ceruloplasmin.

Yosuke Morimitsu, David E. Kleiner, Hari S. Conjeevaram, Chu Chieh Hsia, Adrian M. Di Bisceglie, Edward Tabor – 1 October 1995 – The effect of interferon alfa (IFN‐α) therapy on the expression of transforming growth factor alpha (TGF‐α) in the liver during chronic hepatitis B was investigated. Serial liver biopsy specimens were evaluated from 35 patients who had participated in a randomized, controlled trial of recombinant human IFN‐α for the treatment of chronic hepatitis B.

Shirley Coverdale, Karen Byth, Jacqueline Field, Christopher Liddle, Rita Lin, Geoffrey C. Farrell – 1 October 1995 – To determine whether hepatic metabolic function affects the response to interferon treatment, we measured antipyrine clearance (APC) in 85 patients with chronic active hepatitis C and compared the results with treatment outcome.

Massimo Siciliano, Daniele Tomasello, Alessandro Milani, Bianca Maria Ricerca, Sergio Storti, Lodovico Rossi – 1 October 1995 – Chronic anemia is frequently observed in patients affected by cirrhosis. To investigate the possible role of erythropoietin (Epo) in the pathogenesis of anemia in cirrhosis, we measured the immunoreactive Epo levels and the respective hemoglobin (Hb) concentrations in 48 anemic and nonanemic cirrhotic patients and in a control group of healthy subjects and patients with iron‐deficiency anemia.

Alain Rolachon, Laurent Cordier, Yannick Bacq, Jean‐Baptiste Nousbaum, Anne Franza, Jean‐Claude Paris, Serge Fratte, Benoit Bohn, Pascal Kitmacher, Jean‐Paul Stahl, Jean‐Pierre Zarski – 1 October 1995 – The aim of this prospective double‐blind study was to evaluate the value of long‐term antibiotic prophylaxis using ciprofloxacin for the prevention of spontaneous bacterial peritonitis (SBP) in 60 cirrhotic patients with low ascitic fluid protein levels (<15 g/L).

Onni Nlemelä, Seppo Parkkila, Seppo Ylä‐herttuala, Jesus Villanueva, Boris Ruebner, Charles H. Halsted – 1 October 1995 – The pathogenesis of alcohol‐induced liver disease involves the adverse effects of ethanol metabolites and oxidative tissue injury. Previous studies indicated that covalent protein adducts with reactive aldehydes may be formed in alcohol consumers.

Thomas Leitha, Anton Staudenherz, Marcela Hermann, Manfred Hüttinger, Bernhard Gmeiner – 1 October 1995 – This study quantifies the parenchymal and nonparen‐chymal uptake of technetium‐99m (99mTc)‐ and indium‐III (111In)‐low‐density lipoprotein (LDL) in different states of hepatic LDL‐receptor activity to validate quantitative LDL scintigraphy. Iodine‐125 (125I)‐LDL was used as reference tracer.